6WBQ

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Tubastatin A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0016236	biological_process	macroautophagy
A	0016787	molecular_function	hydrolase activity
A	0019213	molecular_function	deacetylase activity
A	0035825	biological_process	homologous recombination
A	0036269	biological_process	swimming behavior
A	0046872	molecular_function	metal ion binding
A	0047609	molecular_function	acetylputrescine deacetylase activity
A	0047611	molecular_function	acetylspermidine deacetylase activity
A	0090043	biological_process	regulation of tubulin deacetylation
A	0106047	biological_process	polyamine deacetylation
A	0106048	biological_process	spermidine deacetylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue N9W A 701

Chain	Residue
A	GLU24
A	ASP267
A	GLU274
A	TYR307
A	ZN712
A	ALA94
A	HIS136
A	HIS137
A	GLY145
A	PHE146
A	ASP174
A	HIS176
A	TRP205

---

site_id	AC2
Number of Residues	9
Details	binding site for residue EDO A 702

Chain	Residue
A	ALA2
A	VAL119
A	ARG122
A	VAL124
A	ARG125
A	ALA296
A	LYS298
A	HOH818
A	HOH828

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 703

Chain	Residue
A	GLY4
A	SER5
A	ARG125
A	LEU323
A	HOH962

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 704

Chain	Residue
A	GLU59
A	LEU63
A	GLU68
A	GLU72

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 705

Chain	Residue
A	ASN81
A	LYS360
A	HIS361

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 706

Chain	Residue
A	ARG198
A	GLU200
A	GLU276

---

site_id	AC7
Number of Residues	5
Details	binding site for residue K A 707

Chain	Residue
A	ASP172
A	ASP174
A	HIS176
A	SER195
A	TRP196

---

site_id	AC8
Number of Residues	6
Details	binding site for residue K A 708

Chain	Residue
A	PHE185
A	ASP188
A	VAL191
A	PHE224
A	HOH887
A	HOH971

---

site_id	AC9
Number of Residues	10
Details	binding site for residue PO4 A 709

Chain	Residue
A	GLN56
A	LYS106
A	HIS201
A	ASP212
A	TYR213
A	ASN231
A	HOH806
A	HOH813
A	HOH816
A	HOH916

---

site_id	AD1
Number of Residues	7
Details	binding site for residue PO4 A 710

Chain	Residue
A	LYS75
A	HIS201
A	ASN231
A	LYS232
A	SER340
A	GLU343
A	HOH913

---

site_id	AD2
Number of Residues	4
Details	binding site for residue PO4 A 711

Chain	Residue
A	HIS43
A	HIS321
A	LYS407
A	ARG408

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN A 712

Chain	Residue
A	ASP174
A	HIS176
A	ASP267
A	N9W701

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Motif: {"description":"Substrate specificity","evidences":[{"source":"PubMed","id":"28516954","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"28516954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TD7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28516954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TD7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Substrate specificity","evidences":[{"source":"PubMed","id":"28516954","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---