Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0043547 | biological_process | positive regulation of GTPase activity |
| A | 0046580 | biological_process | negative regulation of Ras protein signal transduction |
| B | 0005096 | molecular_function | GTPase activator activity |
| B | 0043547 | biological_process | positive regulation of GTPase activity |
| B | 0046580 | biological_process | negative regulation of Ras protein signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | LYS358 |
| A | SER379 |
| A | ASP380 |
| A | ASN381 |
| A | SER387 |
| A | ARG398 |
| A | HOH603 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | HOH635 |
| A | HOH662 |
| A | LYS349 |
| A | SER418 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | GLY412 |
| A | TYR426 |
| A | ILE431 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | HIS353 |
| A | GLY354 |
| A | LYS355 |
| A | ILE356 |
| A | MET443 |
| A | HOH654 |
| A | HOH689 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| B | LYS358 |
| B | SER379 |
| B | ASP380 |
| B | ASN381 |
| B | SER387 |
| B | ARG398 |
| B | HOH601 |
| B | HOH611 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | GLN370 |
| B | ARG391 |
| B | HOH618 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | PRO345 |
| B | HIS346 |
| B | PHE409 |
| B | ASN417 |
| B | SER418 |
| B | ILE419 |
| B | HOH645 |
| B | HOH682 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | HIS425 |
| B | LYS428 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 180 |
| Details | Domain: {"description":"SH2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
6WAX
