6WA8

Crystal structure of the E. coli transcription termination factor Rho

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006353	biological_process	DNA-templated transcription termination
A	0008186	molecular_function	ATP-dependent activity, acting on RNA
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
B	0000166	molecular_function	nucleotide binding
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006353	biological_process	DNA-templated transcription termination
B	0008186	molecular_function	ATP-dependent activity, acting on RNA
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
C	0000166	molecular_function	nucleotide binding
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006353	biological_process	DNA-templated transcription termination
C	0008186	molecular_function	ATP-dependent activity, acting on RNA
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0042802	molecular_function	identical protein binding
D	0000166	molecular_function	nucleotide binding
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006353	biological_process	DNA-templated transcription termination
D	0008186	molecular_function	ATP-dependent activity, acting on RNA
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0042802	molecular_function	identical protein binding
E	0000166	molecular_function	nucleotide binding
E	0003676	molecular_function	nucleic acid binding
E	0003723	molecular_function	RNA binding
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006353	biological_process	DNA-templated transcription termination
E	0008186	molecular_function	ATP-dependent activity, acting on RNA
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0042802	molecular_function	identical protein binding
F	0000166	molecular_function	nucleotide binding
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0006353	biological_process	DNA-templated transcription termination
F	0008186	molecular_function	ATP-dependent activity, acting on RNA
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue ATP A 501

Chain	Residue
A	LYS181
A	ALA182
A	GLY183
A	LYS184
A	THR185
A	MET186
A	GLU215
A	PHE355

---

site_id	AC2
Number of Residues	11
Details	binding site for residue ATP B 501

Chain	Residue
A	GLU369
B	PRO180
B	LYS181
B	ALA182
B	GLY183
B	LYS184
B	THR185
B	MET186
B	ARG212
B	PHE355
A	ARG366

---

site_id	AC3
Number of Residues	10
Details	binding site for residue ATP C 501

Chain	Residue
B	ARG366
C	PRO180
C	LYS181
C	GLY183
C	LYS184
C	THR185
C	MET186
C	ARG212
C	ARG353
C	PHE355

---

site_id	AC4
Number of Residues	10
Details	binding site for residue ATP D 501

Chain	Residue
C	ARG366
C	GLU369
D	PRO180
D	LYS181
D	ALA182
D	GLY183
D	LYS184
D	THR185
D	MET186
D	PHE355

---

site_id	AC5
Number of Residues	11
Details	binding site for residue ATP E 501

Chain	Residue
D	ARG366
D	GLU369
E	THR158
E	LYS181
E	ALA182
E	GLY183
E	LYS184
E	THR185
E	MET186
E	ARG212
E	PHE355

---

site_id	AC6
Number of Residues	10
Details	binding site for residue ATP F 501

Chain	Residue
E	ARG366
F	PRO180
F	LYS181
F	ALA182
F	GLY183
F	LYS184
F	THR185
F	MET186
F	ARG212
F	PHE355

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	450
Details	Domain: {"description":"Rho RNA-BD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01203","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	54
Details	Region: {"description":"RNA-binding 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Region: {"description":"RNA-binding 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Site: {"description":"RNA-binding 2"}

Chain

Residue

Details

---