6W9D

RNF12 RING domain in complex with a Ube2d2~Ub conjugate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0032991	cellular_component	protein-containing complex
A	0036211	biological_process	protein modification process
A	0051865	biological_process	protein autoubiquitination
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070062	cellular_component	extracellular exosome
A	0070936	biological_process	protein K48-linked ubiquitination
D	0000166	molecular_function	nucleotide binding
D	0000209	biological_process	protein polyubiquitination
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0032991	cellular_component	protein-containing complex
D	0036211	biological_process	protein modification process
D	0051865	biological_process	protein autoubiquitination
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061631	molecular_function	ubiquitin conjugating enzyme activity
D	0070062	cellular_component	extracellular exosome
D	0070936	biological_process	protein K48-linked ubiquitination
G	0000166	molecular_function	nucleotide binding
G	0000209	biological_process	protein polyubiquitination
G	0004842	molecular_function	ubiquitin-protein transferase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016567	biological_process	protein ubiquitination
G	0016740	molecular_function	transferase activity
G	0032991	cellular_component	protein-containing complex
G	0036211	biological_process	protein modification process
G	0051865	biological_process	protein autoubiquitination
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0061631	molecular_function	ubiquitin conjugating enzyme activity
G	0070062	cellular_component	extracellular exosome
G	0070936	biological_process	protein K48-linked ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 701

Chain	Residue
B	CYS570
B	CYS573
B	HIS593
B	CYS596

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 702

Chain	Residue
B	CYS588
B	HIS590
B	CYS607
B	CYS610

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN E 701

Chain	Residue
E	CYS573
E	HIS593
E	CYS596
E	CYS570

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN E 702

Chain	Residue
E	CYS588
E	HIS590
E	CYS607
E	CYS610

---

site_id	AC5
Number of Residues	2
Details	binding site for residue IOD G 201

Chain	Residue
G	LYS4
G	LEU148

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN H 701

Chain	Residue
G	ARG72
H	CYS570
H	CYS573
H	HIS593
H	CYS596

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN H 702

Chain	Residue
H	CYS588
H	HIS590
H	CYS607
H	CYS610

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
C	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	146
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	123
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---