6W6F
Structural and catalytic roles of human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000154 | biological_process | rRNA modification |
| A | 0000179 | molecular_function | rRNA (adenine-N6,N6-)-dimethyltransferase activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006364 | biological_process | rRNA processing |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0031167 | biological_process | rRNA methylation |
| A | 0032040 | cellular_component | small-subunit processome |
| A | 0032259 | biological_process | methylation |
| A | 0042274 | biological_process | ribosomal small subunit biogenesis |
| A | 0052909 | molecular_function | 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity |
| A | 2000234 | biological_process | positive regulation of rRNA processing |
| B | 0000154 | biological_process | rRNA modification |
| B | 0000179 | molecular_function | rRNA (adenine-N6,N6-)-dimethyltransferase activity |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006364 | biological_process | rRNA processing |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0031167 | biological_process | rRNA methylation |
| B | 0032040 | cellular_component | small-subunit processome |
| B | 0032259 | biological_process | methylation |
| B | 0042274 | biological_process | ribosomal small subunit biogenesis |
| B | 0052909 | molecular_function | 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity |
| B | 2000234 | biological_process | positive regulation of rRNA processing |
Functional Information from PROSITE/UniProt
| site_id | PS01131 |
| Number of Residues | 28 |
| Details | RRNA_A_DIMETH Ribosomal RNA adenine dimethylases signature. VLEvGPGtGnMTvklLekakk...VvACElD |
| Chain | Residue | Details |
| A | VAL60-ASP87 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01026","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2005","submissionDatabase":"PDB data bank","title":"Crystal structure of human dimethyladenosine transferase with SAM.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
