6W6C

Structural and catalytic roles of human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000154	biological_process	rRNA modification
A	0000179	molecular_function	rRNA (adenine-N6,N6-)-dimethyltransferase activity
A	0003723	molecular_function	RNA binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005829	cellular_component	cytosol
A	0006364	biological_process	rRNA processing
A	0008168	molecular_function	methyltransferase activity
A	0031167	biological_process	rRNA methylation
A	0032040	cellular_component	small-subunit processome
A	0032259	biological_process	methylation
A	0042274	biological_process	ribosomal small subunit biogenesis
A	0052909	molecular_function	18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
A	2000234	biological_process	positive regulation of rRNA processing
B	0000154	biological_process	rRNA modification
B	0000179	molecular_function	rRNA (adenine-N6,N6-)-dimethyltransferase activity
B	0003723	molecular_function	RNA binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005829	cellular_component	cytosol
B	0006364	biological_process	rRNA processing
B	0008168	molecular_function	methyltransferase activity
B	0031167	biological_process	rRNA methylation
B	0032040	cellular_component	small-subunit processome
B	0032259	biological_process	methylation
B	0042274	biological_process	ribosomal small subunit biogenesis
B	0052909	molecular_function	18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
B	2000234	biological_process	positive regulation of rRNA processing

Functional Information from PROSITE/UniProt

site_id	PS01131
Number of Residues	28
Details	RRNA_A_DIMETH Ribosomal RNA adenine dimethylases signature. VLEvGPGtGnMTvklLekakk...VvACElD

Chain	Residue	Details
A	VAL60-ASP87

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01026, ECO:0000269|Ref.9

Chain	Residue	Details
A	ASP113
A	ASN128
B	HIS37
B	LEU39
B	GLY64
B	GLU85
B	ASP113
B	ASN128
A	GLY64
A	GLU85
A	HIS37
A	LEU39

---