6W4N
Co-crystal structure of Pd_dinase with probe glycine-propargylglycine-AOMK
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0016020 | cellular_component | membrane |
| A | 0043418 | biological_process | L-homocysteine catabolic process |
| A | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0016020 | cellular_component | membrane |
| B | 0043418 | biological_process | L-homocysteine catabolic process |
| B | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0016020 | cellular_component | membrane |
| C | 0043418 | biological_process | L-homocysteine catabolic process |
| C | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| D | 0009636 | biological_process | response to toxic substance |
| D | 0016020 | cellular_component | membrane |
| D | 0043418 | biological_process | L-homocysteine catabolic process |
| D | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
| E | 0004177 | molecular_function | aminopeptidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006508 | biological_process | proteolysis |
| E | 0008234 | molecular_function | cysteine-type peptidase activity |
| E | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| E | 0009636 | biological_process | response to toxic substance |
| E | 0016020 | cellular_component | membrane |
| E | 0043418 | biological_process | L-homocysteine catabolic process |
| E | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
| F | 0004177 | molecular_function | aminopeptidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006508 | biological_process | proteolysis |
| F | 0008234 | molecular_function | cysteine-type peptidase activity |
| F | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| F | 0009636 | biological_process | response to toxic substance |
| F | 0016020 | cellular_component | membrane |
| F | 0043418 | biological_process | L-homocysteine catabolic process |
| F | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue SWJ A 601 |
| Chain | Residue |
| A | GLN50 |
| A | HIS340 |
| A | GLY54 |
| A | CYS56 |
| A | TRP57 |
| A | GLY108 |
| A | GLY109 |
| A | ASP237 |
| A | ASP338 |
| A | ASP339 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue K A 602 |
| Chain | Residue |
| A | ASP271 |
| A | SER273 |
| A | GLU274 |
| A | GLU335 |
| A | HOH715 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue K A 603 |
| Chain | Residue |
| A | ASP78 |
| A | LEU79 |
| A | GLU81 |
| A | GLU126 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue K B 602 |
| Chain | Residue |
| B | ASP78 |
| B | LEU79 |
| B | GLU81 |
| B | GLU126 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue K B 603 |
| Chain | Residue |
| B | ASP271 |
| B | SER273 |
| B | GLU274 |
| B | GLU335 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue SWJ C 601 |
| Chain | Residue |
| C | GLN50 |
| C | GLY54 |
| C | CYS56 |
| C | TRP57 |
| C | GLY108 |
| C | GLY109 |
| C | ASP237 |
| C | ASP338 |
| C | ASP339 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue K C 602 |
| Chain | Residue |
| C | ASP271 |
| C | SER273 |
| C | GLU274 |
| C | GLU335 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue K C 603 |
| Chain | Residue |
| C | GLU66 |
| C | ASP78 |
| C | LEU79 |
| C | GLU81 |
| C | GLU126 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue K D 602 |
| Chain | Residue |
| D | ASP78 |
| D | LEU79 |
| D | GLU81 |
| D | GLU126 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue K D 603 |
| Chain | Residue |
| D | ASP271 |
| D | SER273 |
| D | GLU274 |
| D | GLU335 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue K E 602 |
| Chain | Residue |
| E | ASP78 |
| E | LEU79 |
| E | GLU81 |
| E | GLU126 |
| E | HOH827 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue K E 603 |
| Chain | Residue |
| E | ASP271 |
| E | SER273 |
| E | GLU274 |
| E | GLU335 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue K F 602 |
| Chain | Residue |
| F | ASP271 |
| F | SER273 |
| F | GLU274 |
| F | GLU335 |
| F | HOH715 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue K F 603 |
| Chain | Residue |
| F | ASP78 |
| F | LEU79 |
| F | GLU81 |
| F | GLU126 |
| F | HOH794 |
| site_id | AD6 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide SWJ B 601 and CYS B 56 |
| Chain | Residue |
| B | GLN50 |
| B | GLY54 |
| B | THR55 |
| B | TRP57 |
| B | CYS58 |
| B | TYR59 |
| B | SER60 |
| B | GLY108 |
| B | GLY109 |
| B | ASP237 |
| B | ASP338 |
| B | ASP339 |
| B | HIS340 |
| B | GLY341 |
| site_id | AD7 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide SWJ D 601 and CYS D 56 |
| Chain | Residue |
| D | GLY341 |
| D | GLN50 |
| D | GLY54 |
| D | THR55 |
| D | TRP57 |
| D | CYS58 |
| D | TYR59 |
| D | SER60 |
| D | GLY108 |
| D | GLY109 |
| D | ASP237 |
| D | ASP338 |
| D | ASP339 |
| D | HIS340 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide SWJ D 601 and ASP D 338 |
| Chain | Residue |
| D | GLN50 |
| D | GLY54 |
| D | THR55 |
| D | CYS56 |
| D | GLY108 |
| D | GLY109 |
| D | ASP237 |
| D | THR337 |
| D | ASP339 |
| D | HIS340 |
| site_id | AD9 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide SWJ E 601 and CYS E 56 |
| Chain | Residue |
| E | GLN50 |
| E | GLY54 |
| E | THR55 |
| E | TRP57 |
| E | CYS58 |
| E | TYR59 |
| E | SER60 |
| E | GLY108 |
| E | GLY109 |
| E | ASP237 |
| E | ASP338 |
| E | ASP339 |
| E | HIS340 |
| E | GLY341 |
| E | HOH702 |
| site_id | AE1 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide SWJ F 601 and CYS F 56 |
| Chain | Residue |
| F | GLN50 |
| F | GLY54 |
| F | THR55 |
| F | TRP57 |
| F | CYS58 |
| F | TYR59 |
| F | SER60 |
| F | GLY108 |
| F | GLY109 |
| F | ASP237 |
| F | ASP338 |
| F | ASP339 |
| F | HIS340 |
| F | GLY341 |
| F | HOH704 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QNrAGTCWCySS |
| Chain | Residue | Details |
| A | GLN50-SER61 |
