6W3C
Structure of phosphorylated apo IRE1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004521 | molecular_function | RNA endonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006397 | biological_process | mRNA processing |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0030968 | biological_process | endoplasmic reticulum unfolded protein response |
| B | 0004521 | molecular_function | RNA endonuclease activity |
| B | 0004540 | molecular_function | RNA nuclease activity |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006397 | biological_process | mRNA processing |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0030968 | biological_process | endoplasmic reticulum unfolded protein response |
| C | 0004521 | molecular_function | RNA endonuclease activity |
| C | 0004540 | molecular_function | RNA nuclease activity |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004674 | molecular_function | protein serine/threonine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006397 | biological_process | mRNA processing |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0030968 | biological_process | endoplasmic reticulum unfolded protein response |
| D | 0004521 | molecular_function | RNA endonuclease activity |
| D | 0004540 | molecular_function | RNA nuclease activity |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004674 | molecular_function | protein serine/threonine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006397 | biological_process | mRNA processing |
| D | 0006468 | biological_process | protein phosphorylation |
| D | 0030968 | biological_process | endoplasmic reticulum unfolded protein response |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKphNILI |
| Chain | Residue | Details |
| A | ILE684-ILE696 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P32361, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP688 | |
| B | ASP688 | |
| C | ASP688 | |
| D | ASP688 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P32361, ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU577 | |
| B | LEU577 | |
| C | LEU577 | |
| D | LEU577 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:21317875, ECO:0000269|PubMed:9637683, ECO:0007744|PDB:3P23 |
| Chain | Residue | Details |
| A | LYS599 | |
| B | LYS599 | |
| C | LYS599 | |
| D | LYS599 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21317875, ECO:0007744|PDB:3P23 |
| Chain | Residue | Details |
| A | GLU643 | |
| D | GLU643 | |
| D | LYS690 | |
| D | ASP711 | |
| A | LYS690 | |
| A | ASP711 | |
| B | GLU643 | |
| B | LYS690 | |
| B | ASP711 | |
| C | GLU643 | |
| C | LYS690 | |
| C | ASP711 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Interacts with hydroxy-aryl-aldehyde inhibitors => ECO:0000250|UniProtKB:Q9EQY0 |
| Chain | Residue | Details |
| A | TYR892 | |
| B | TYR892 | |
| C | TYR892 | |
| D | TYR892 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:30118681 |
| Chain | Residue | Details |
| A | SEP724 | |
| A | SEP729 | |
| B | SEP724 | |
| B | SEP729 | |
| C | SEP724 | |
| C | SEP729 | |
| D | SEP724 | |
| D | SEP729 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | THR973 | |
| B | THR973 | |
| C | THR973 | |
| D | THR973 |
