6W1I
Re-interpretation of ppGpp (G4P) electron density in the deposited crystal structure of Xanthine phosphoribosyltransferase (XPRT) (1Y0B).
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0032265 | biological_process | XMP salvage |
| A | 0043101 | biological_process | purine-containing compound salvage |
| A | 0046110 | biological_process | xanthine metabolic process |
| B | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0032265 | biological_process | XMP salvage |
| B | 0043101 | biological_process | purine-containing compound salvage |
| B | 0046110 | biological_process | xanthine metabolic process |
| C | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0032265 | biological_process | XMP salvage |
| C | 0043101 | biological_process | purine-containing compound salvage |
| C | 0046110 | biological_process | xanthine metabolic process |
| D | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0032265 | biological_process | XMP salvage |
| D | 0043101 | biological_process | purine-containing compound salvage |
| D | 0046110 | biological_process | xanthine metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 201 |
| Chain | Residue |
| A | ASP125 |
| A | NA202 |
| A | G4P203 |
| A | HOH429 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 202 |
| Chain | Residue |
| A | HOH347 |
| A | ASP124 |
| A | ASP125 |
| A | NA201 |
| A | G4P203 |
| A | HOH346 |
| site_id | AC3 |
| Number of Residues | 32 |
| Details | binding site for residue G4P A 203 |
| Chain | Residue |
| A | VAL19 |
| A | LEU20 |
| A | ASN27 |
| A | GLU58 |
| A | SER59 |
| A | SER60 |
| A | LYS81 |
| A | SER98 |
| A | THR100 |
| A | ASP125 |
| A | PHE126 |
| A | ALA128 |
| A | ASN129 |
| A | LYS156 |
| A | NA201 |
| A | NA202 |
| A | HOH312 |
| A | HOH316 |
| A | HOH321 |
| A | HOH331 |
| A | HOH347 |
| A | HOH353 |
| A | HOH381 |
| A | HOH382 |
| A | HOH389 |
| A | HOH391 |
| A | HOH396 |
| A | HOH400 |
| A | HOH429 |
| A | HOH433 |
| B | ARG80 |
| B | LEU85 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 201 |
| Chain | Residue |
| B | ASP125 |
| B | NA202 |
| B | G4P203 |
| B | HOH403 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 202 |
| Chain | Residue |
| B | ASP124 |
| B | ASP125 |
| B | NA201 |
| B | G4P203 |
| B | HOH306 |
| B | HOH344 |
| site_id | AC6 |
| Number of Residues | 31 |
| Details | binding site for residue G4P B 203 |
| Chain | Residue |
| A | ARG80 |
| A | LEU85 |
| A | THR86 |
| B | GLN18 |
| B | VAL19 |
| B | LEU20 |
| B | ASN27 |
| B | GLU58 |
| B | SER59 |
| B | SER60 |
| B | LYS81 |
| B | SER98 |
| B | ASP125 |
| B | PHE126 |
| B | ALA128 |
| B | ASN129 |
| B | LYS156 |
| B | NA201 |
| B | NA202 |
| B | HOH305 |
| B | HOH314 |
| B | HOH322 |
| B | HOH341 |
| B | HOH344 |
| B | HOH353 |
| B | HOH356 |
| B | HOH364 |
| B | HOH372 |
| B | HOH384 |
| B | HOH394 |
| B | HOH403 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue NA C 201 |
| Chain | Residue |
| C | ASP125 |
| C | NA202 |
| C | G4P203 |
| C | HOH396 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 202 |
| Chain | Residue |
| C | ASP124 |
| C | ASP125 |
| C | NA201 |
| C | G4P203 |
| C | HOH317 |
| C | HOH368 |
| site_id | AC9 |
| Number of Residues | 32 |
| Details | binding site for residue G4P C 203 |
| Chain | Residue |
| C | LYS81 |
| C | TYR97 |
| C | SER98 |
| C | PHE99 |
| C | THR100 |
| C | ASP125 |
| C | PHE126 |
| C | ALA128 |
| C | ASN129 |
| C | LYS156 |
| C | NA201 |
| C | NA202 |
| C | HOH305 |
| C | HOH319 |
| C | HOH337 |
| C | HOH339 |
| C | HOH350 |
| C | HOH357 |
| C | HOH365 |
| C | HOH368 |
| C | HOH372 |
| C | HOH374 |
| C | HOH387 |
| C | HOH396 |
| D | ARG80 |
| D | LEU85 |
| C | VAL19 |
| C | LEU20 |
| C | ASN27 |
| C | GLU58 |
| C | SER59 |
| C | SER60 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue NA D 201 |
| Chain | Residue |
| D | ASP125 |
| D | NA202 |
| D | G4P203 |
| D | HOH402 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 202 |
| Chain | Residue |
| D | ASP124 |
| D | ASP125 |
| D | NA201 |
| D | G4P203 |
| D | HOH321 |
| D | HOH336 |
| site_id | AD3 |
| Number of Residues | 32 |
| Details | binding site for residue G4P D 203 |
| Chain | Residue |
| C | ARG80 |
| C | LEU85 |
| D | GLN18 |
| D | VAL19 |
| D | LEU20 |
| D | ASN27 |
| D | GLU58 |
| D | SER59 |
| D | SER60 |
| D | LYS81 |
| D | SER98 |
| D | PHE99 |
| D | THR100 |
| D | ASP125 |
| D | PHE126 |
| D | ASN129 |
| D | LYS156 |
| D | NA201 |
| D | NA202 |
| D | HOH310 |
| D | HOH311 |
| D | HOH314 |
| D | HOH317 |
| D | HOH326 |
| D | HOH334 |
| D | HOH336 |
| D | HOH372 |
| D | HOH381 |
| D | HOH392 |
| D | HOH402 |
| D | HOH404 |
| D | HOH420 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LEU20 | |
| C | ASN27 | |
| C | ALA128 | |
| C | LYS156 | |
| D | LEU20 | |
| D | ASN27 | |
| D | ALA128 | |
| D | LYS156 | |
| A | ASN27 | |
| A | ALA128 | |
| A | LYS156 | |
| B | LEU20 | |
| B | ASN27 | |
| B | ALA128 | |
| B | LYS156 | |
| C | LEU20 |
