Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VZW

TTLL6 bound to the initiation analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0036211	biological_process	protein modification process
B	0036211	biological_process	protein modification process
C	0036211	biological_process	protein modification process
D	0036211	biological_process	protein modification process

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue 2TI A 601

Chain	Residue
A	TYR69
A	SER266
A	LYS283
A	ASP346
A	GLU359
A	ASN361
A	HIS362
A	SER363
A	PRO364
A	SER365
A	LYS377
A	CYS123
A	ADP604
A	MG605
A	MG606
A	HOH702
C	LYS194
A	CYS179
A	GLN180
A	ARG219
A	LEU239
A	ARG241
A	ASN264
A	TYR265

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL A 602

Chain	Residue
A	ARG68
A	TYR69
A	ASP70
A	SER367

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 603

Chain	Residue
A	GLU301
A	ARG305
A	ARG445

site_id	AC4
Number of Residues	23
Details	binding site for residue ADP A 604

Chain	Residue
A	LYS125
A	ILE172
A	LYS174
A	CYS179
A	GLN180
A	GLY181
A	ILE184
A	GLN202
A	LEU203
A	TYR204
A	ILE205
A	LYS215
A	ASP217
A	LEU262
A	THR263
A	ASN264
A	ASP346
A	LEU348
A	LEU358
A	GLU359
A	2TI601
A	MG605
A	MG606

site_id	AC5
Number of Residues	5
Details	binding site for residue MG A 605

Chain	Residue
A	ASN264
A	ASP346
A	GLU359
A	2TI601
A	ADP604

site_id	AC6
Number of Residues	5
Details	binding site for residue MG A 606

Chain	Residue
A	LYS125
A	GLU359
A	ASN361
A	2TI601
A	ADP604

site_id	AC7
Number of Residues	28
Details	binding site for residue 2TI B 601

Chain	Residue
B	TYR69
B	CYS123
B	CYS179
B	GLN180
B	ARG219
B	TYR221
B	LEU239
B	ARG241
B	ASN264
B	TYR265
B	SER266
B	LYS283
B	ASP346
B	GLU359
B	VAL360
B	ASN361
B	HIS362
B	SER363
B	PRO364
B	SER365
B	LYS377
B	ADP610
B	MG611
B	MG612
B	HOH712
B	HOH716
B	HOH739
D	LYS194

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL B 602

Chain	Residue
B	ASP299
B	GLN302
B	ARG305

site_id	AC9
Number of Residues	3
Details	binding site for residue GOL B 603

Chain	Residue
B	ASP142
B	ASP309
B	LYS313

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL B 604

Chain	Residue
B	TYR69
B	ASP70
B	SER367
B	HOH733
B	ARG68

site_id	AD2
Number of Residues	3
Details	binding site for residue GOL B 605

Chain	Residue
B	ILE210
B	ASP212
B	GLY213

site_id	AD3
Number of Residues	2
Details	binding site for residue GOL B 606

Chain	Residue
B	GLN78
B	TYR382

site_id	AD4
Number of Residues	1
Details	binding site for residue GOL B 607

Chain	Residue
B	ARG351

site_id	AD5
Number of Residues	2
Details	binding site for residue GOL B 608

Chain	Residue
B	GLU375
B	HOH774

site_id	AD6
Number of Residues	1
Details	binding site for residue GOL B 609

Chain	Residue
B	TYR79

site_id	AD7
Number of Residues	26
Details	binding site for residue ADP B 610

Chain	Residue
B	LYS125
B	ILE172
B	LYS174
B	CYS179
B	GLN180
B	GLY181
B	ILE184
B	GLN202
B	LEU203
B	TYR204
B	ILE205
B	LYS215
B	ASP217
B	HIS261
B	LEU262
B	THR263
B	ASN264
B	ASP346
B	LEU348
B	LEU358
B	GLU359
B	2TI601
B	MG611
B	MG612
B	HOH712
B	HOH739

site_id	AD8
Number of Residues	6
Details	binding site for residue MG B 611

Chain	Residue
B	GLU359
B	ASN361
B	2TI601
B	ADP610
B	MG612
B	HOH712

site_id	AD9
Number of Residues	7
Details	binding site for residue MG B 612

Chain	Residue
B	ASN264
B	ASP346
B	GLU359
B	2TI601
B	ADP610
B	MG611
B	HOH739

site_id	AE1
Number of Residues	24
Details	binding site for residue 2TI C 601

Chain	Residue
A	LYS194
C	ARG68
C	GLY178
C	CYS179
C	GLN180
C	ARG219
C	LEU239
C	ARG241
C	ASN264
C	TYR265
C	SER266
C	LYS283
C	ASP346
C	GLU359
C	ASN361
C	HIS362
C	SER363
C	PRO364
C	SER365
C	ASP373
C	LYS377
C	ADP605
C	MG606
C	MG607

site_id	AE2
Number of Residues	5
Details	binding site for residue GOL C 602

Chain	Residue
C	ASN236
C	ASN290
C	GLU301
C	ARG305
C	ARG445

site_id	AE3
Number of Residues	4
Details	binding site for residue GOL C 603

Chain	Residue
C	ARG305
C	GLU308
C	ILE447
C	TYR456

site_id	AE4
Number of Residues	4
Details	binding site for residue GOL C 604

Chain	Residue
C	ARG68
C	TYR69
C	ASP70
C	SER367

site_id	AE5
Number of Residues	24
Details	binding site for residue ADP C 605

Chain	Residue
C	LYS125
C	ILE172
C	LYS174
C	GLY178
C	CYS179
C	GLN180
C	GLY181
C	ILE184
C	GLN202
C	LEU203
C	TYR204
C	ILE205
C	LYS215
C	ASP217
C	LEU262
C	THR263
C	ASN264
C	ASP346
C	LEU348
C	LEU358
C	GLU359
C	2TI601
C	MG606
C	MG607

site_id	AE6
Number of Residues	5
Details	binding site for residue MG C 606

Chain	Residue
C	GLY178
C	GLU359
C	ASN361
C	2TI601
C	ADP605

site_id	AE7
Number of Residues	6
Details	binding site for residue MG C 607

Chain	Residue
C	ARG241
C	ASN264
C	ASP346
C	GLU359
C	2TI601
C	ADP605

site_id	AE8
Number of Residues	29
Details	binding site for residue 2TI D 601

Chain	Residue
B	LYS194
D	TYR69
D	CYS123
D	CYS179
D	GLN180
D	ARG219
D	TYR221
D	LEU239
D	ARG241
D	ASN264
D	TYR265
D	SER266
D	LYS283
D	ASP346
D	GLU359
D	VAL360
D	ASN361
D	HIS362
D	SER363
D	PRO364
D	SER365
D	ASP373
D	LYS377
D	ADP609
D	MG610
D	MG611
D	HOH710
D	HOH720
D	HOH728

site_id	AE9
Number of Residues	8
Details	binding site for residue GOL D 602

Chain	Residue
B	LYS194
B	PRO195
B	GLY196
D	ASP96
D	TYR97
D	SER98
D	HIS362
D	HOH758

site_id	AF1
Number of Residues	8
Details	binding site for residue GOL D 603

Chain	Residue
D	PHE214
D	PHE242
D	ALA243
D	ASN273
D	VAL275
D	GLY281
D	SER282
D	ARG284

site_id	AF2
Number of Residues	3
Details	binding site for residue GOL D 604

Chain	Residue
D	VAL300
D	GLU301
D	ARG445

site_id	AF3
Number of Residues	3
Details	binding site for residue GOL D 605

Chain	Residue
D	ASP299
D	GLU301
D	ARG305

site_id	AF4
Number of Residues	5
Details	binding site for residue GOL D 606

Chain	Residue
D	ARG68
D	TYR69
D	ASP70
D	SER367
D	THR368

site_id	AF5
Number of Residues	1
Details	binding site for residue GOL D 607

Chain	Residue
D	TYR97

site_id	AF6
Number of Residues	2
Details	binding site for residue GOL D 608

Chain	Residue
D	GLN302
D	HOH707

site_id	AF7
Number of Residues	26
Details	binding site for residue ADP D 609

Chain	Residue
D	LYS125
D	ILE172
D	LYS174
D	CYS179
D	GLN180
D	GLY181
D	ILE184
D	GLN202
D	LEU203
D	TYR204
D	ILE205
D	LYS215
D	ASP217
D	HIS261
D	LEU262
D	THR263
D	ASN264
D	ASP346
D	LEU348
D	LEU358
D	GLU359
D	2TI601
D	MG610
D	MG611
D	HOH708
D	HOH728

site_id	AF8
Number of Residues	5
Details	binding site for residue MG D 610

Chain	Residue
D	GLU359
D	ASN361
D	2TI601
D	ADP609
D	HOH710

site_id	AF9
Number of Residues	5
Details	binding site for residue MG D 611

Chain	Residue
D	ASP346
D	GLU359
D	2TI601
D	ADP609
D	HOH728

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	158
Details	Region: {"description":"c-MTBD region","evidences":[{"source":"UniProtKB","id":"Q8N841","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6VZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Essential for specifying alpha-elongation versus initiation step of the polyglutamylase activity","evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Important for specifying alpha-elongation versus initiation step of the polyglutamylase activity","evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	686
Details	Domain: {"description":"TTL","evidences":[{"source":"PROSITE-ProRule","id":"PRU00568","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)