6VZU
TTLL6 bound to alpha-elongation analog
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 601 |
| Chain | Residue |
| A | PHE214 |
| A | ARG284 |
| A | PHE242 |
| A | ALA243 |
| A | THR244 |
| A | ASN273 |
| A | VAL275 |
| A | SER280 |
| A | GLY281 |
| A | SER282 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | ARG59 |
| A | GLN77 |
| A | TYR79 |
| A | GLY80 |
| A | HOH705 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | GLU301 |
| A | ARG305 |
| A | ARG445 |
| A | HOH823 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | ASP309 |
| A | LYS455 |
| A | TYR456 |
| A | HOH777 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | binding site for residue RZP A 605 |
| Chain | Residue |
| A | TYR69 |
| A | CYS179 |
| A | GLN180 |
| A | ARG219 |
| A | LEU239 |
| A | ARG241 |
| A | ASN264 |
| A | TYR265 |
| A | SER266 |
| A | LYS283 |
| A | ASP346 |
| A | GLU359 |
| A | ASN361 |
| A | HIS362 |
| A | SER363 |
| A | PRO364 |
| A | SER365 |
| A | LYS377 |
| A | ADP606 |
| A | MG607 |
| A | MG608 |
| A | HOH719 |
| A | HOH734 |
| A | HOH746 |
| A | HOH753 |
| A | HOH761 |
| C | LYS194 |
| site_id | AC6 |
| Number of Residues | 26 |
| Details | binding site for residue ADP A 606 |
| Chain | Residue |
| A | LYS125 |
| A | ILE172 |
| A | LYS174 |
| A | CYS179 |
| A | GLN180 |
| A | GLY181 |
| A | ILE184 |
| A | GLN202 |
| A | LEU203 |
| A | TYR204 |
| A | ILE205 |
| A | LYS215 |
| A | ASP217 |
| A | LEU262 |
| A | THR263 |
| A | ASN264 |
| A | ASP346 |
| A | LEU348 |
| A | LEU358 |
| A | GLU359 |
| A | RZP605 |
| A | MG607 |
| A | MG608 |
| A | HOH744 |
| A | HOH746 |
| A | HOH761 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 607 |
| Chain | Residue |
| A | ASP346 |
| A | GLU359 |
| A | RZP605 |
| A | ADP606 |
| A | MG608 |
| A | HOH761 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 608 |
| Chain | Residue |
| A | GLU359 |
| A | ASN361 |
| A | RZP605 |
| A | ADP606 |
| A | MG607 |
| A | HOH746 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 609 |
| Chain | Residue |
| A | LYS374 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 601 |
| Chain | Residue |
| B | ARG68 |
| B | TYR69 |
| B | ASP70 |
| B | SER367 |
| B | HOH791 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 602 |
| Chain | Residue |
| B | HOH817 |
| B | HOH876 |
| B | ASN290 |
| B | GLU301 |
| B | ARG305 |
| B | ARG445 |
| B | HOH719 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| B | GLU308 |
| B | ILE312 |
| B | ILE447 |
| B | ASN452 |
| B | LYS455 |
| B | TYR456 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| B | SER133 |
| B | ARG148 |
| B | THR149 |
| B | TRP150 |
| B | HOH866 |
| site_id | AD5 |
| Number of Residues | 27 |
| Details | binding site for residue RZP B 605 |
| Chain | Residue |
| B | TYR69 |
| B | CYS179 |
| B | GLN180 |
| B | ARG219 |
| B | LEU239 |
| B | ARG241 |
| B | ASN264 |
| B | TYR265 |
| B | SER266 |
| B | LYS283 |
| B | ASP346 |
| B | GLU359 |
| B | ASN361 |
| B | HIS362 |
| B | SER363 |
| B | PRO364 |
| B | SER365 |
| B | LYS377 |
| B | ADP606 |
| B | MG607 |
| B | MG608 |
| B | HOH732 |
| B | HOH737 |
| B | HOH745 |
| B | HOH754 |
| B | HOH765 |
| D | LYS194 |
| site_id | AD6 |
| Number of Residues | 26 |
| Details | binding site for residue ADP B 606 |
| Chain | Residue |
| B | LYS125 |
| B | ILE172 |
| B | LYS174 |
| B | CYS179 |
| B | GLN180 |
| B | GLY181 |
| B | ILE184 |
| B | GLN202 |
| B | LEU203 |
| B | TYR204 |
| B | ILE205 |
| B | LYS215 |
| B | ASP217 |
| B | LEU262 |
| B | THR263 |
| B | ASN264 |
| B | ASP346 |
| B | LEU348 |
| B | LEU358 |
| B | GLU359 |
| B | RZP605 |
| B | MG607 |
| B | MG608 |
| B | HOH732 |
| B | HOH754 |
| B | HOH796 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 607 |
| Chain | Residue |
| B | ASP346 |
| B | GLU359 |
| B | RZP605 |
| B | ADP606 |
| B | MG608 |
| B | HOH754 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 608 |
| Chain | Residue |
| B | GLU359 |
| B | ASN361 |
| B | RZP605 |
| B | ADP606 |
| B | MG607 |
| B | HOH732 |
| site_id | AD9 |
| Number of Residues | 12 |
| Details | binding site for residue RZV C 701 |
| Chain | Residue |
| C | ARG148 |
| C | TYR162 |
| C | LYS169 |
| C | THR170 |
| C | LEU203 |
| C | TYR204 |
| C | ILE205 |
| C | SER206 |
| C | LYS207 |
| C | TRP356 |
| C | HOH854 |
| C | HOH916 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 702 |
| Chain | Residue |
| C | GLU359 |
| C | ASN361 |
| C | MG703 |
| C | RZP705 |
| C | ADP706 |
| C | HOH841 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 703 |
| Chain | Residue |
| C | ASP346 |
| C | GLU359 |
| C | MG702 |
| C | RZP705 |
| C | ADP706 |
| C | HOH842 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 704 |
| Chain | Residue |
| C | PHE209 |
| C | ILE210 |
| C | ARG351 |
| C | HOH821 |
| C | HOH849 |
| site_id | AE4 |
| Number of Residues | 28 |
| Details | binding site for residue RZP C 705 |
| Chain | Residue |
| A | LYS194 |
| C | TYR69 |
| C | CYS179 |
| C | GLN180 |
| C | ARG219 |
| C | LEU239 |
| C | ARG241 |
| C | ASN264 |
| C | TYR265 |
| C | SER266 |
| C | LYS283 |
| C | ASP346 |
| C | GLU359 |
| C | ASN361 |
| C | HIS362 |
| C | SER363 |
| C | PRO364 |
| C | SER365 |
| C | LYS377 |
| C | MG702 |
| C | MG703 |
| C | ADP706 |
| C | HOH826 |
| C | HOH835 |
| C | HOH841 |
| C | HOH842 |
| C | HOH855 |
| C | HOH874 |
| site_id | AE5 |
| Number of Residues | 26 |
| Details | binding site for residue ADP C 706 |
| Chain | Residue |
| C | LYS125 |
| C | ILE172 |
| C | LYS174 |
| C | CYS179 |
| C | GLN180 |
| C | GLY181 |
| C | ILE184 |
| C | GLN202 |
| C | LEU203 |
| C | TYR204 |
| C | ILE205 |
| C | LYS215 |
| C | ASP217 |
| C | LEU262 |
| C | THR263 |
| C | ASN264 |
| C | ASP346 |
| C | LEU348 |
| C | LEU358 |
| C | GLU359 |
| C | MG702 |
| C | MG703 |
| C | RZP705 |
| C | HOH841 |
| C | HOH842 |
| C | HOH896 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 601 |
| Chain | Residue |
| D | ASN290 |
| D | GLU301 |
| D | ARG305 |
| D | ARG445 |
| D | HOH840 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 602 |
| Chain | Residue |
| D | ALA76 |
| D | GLN77 |
| D | GLY80 |
| D | LEU81 |
| D | GOL604 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 603 |
| Chain | Residue |
| D | GLN302 |
| D | ARG305 |
| D | HOH701 |
| D | HOH787 |
| D | HOH843 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 604 |
| Chain | Residue |
| D | GLN77 |
| D | GLN78 |
| D | TYR79 |
| D | GLY80 |
| D | GOL602 |
| D | HOH710 |
| D | HOH726 |
| site_id | AF1 |
| Number of Residues | 10 |
| Details | binding site for residue GOL D 605 |
| Chain | Residue |
| D | PHE214 |
| D | PHE242 |
| D | ALA243 |
| D | THR244 |
| D | ASN273 |
| D | VAL275 |
| D | SER280 |
| D | GLY281 |
| D | SER282 |
| D | ARG284 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 606 |
| Chain | Residue |
| D | GLN78 |
| D | ASP378 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 607 |
| Chain | Residue |
| D | ASP142 |
| D | ASP309 |
| D | LYS313 |
| site_id | AF4 |
| Number of Residues | 28 |
| Details | binding site for residue RZP D 608 |
| Chain | Residue |
| B | LYS194 |
| D | TYR69 |
| D | CYS179 |
| D | GLN180 |
| D | ARG219 |
| D | LEU239 |
| D | ARG241 |
| D | ASN264 |
| D | TYR265 |
| D | SER266 |
| D | LYS283 |
| D | ASP346 |
| D | GLU359 |
| D | ASN361 |
| D | HIS362 |
| D | SER363 |
| D | PRO364 |
| D | SER365 |
| D | LYS377 |
| D | ADP609 |
| D | MG610 |
| D | MG611 |
| D | HOH725 |
| D | HOH731 |
| D | HOH738 |
| D | HOH742 |
| D | HOH749 |
| D | HOH798 |
| site_id | AF5 |
| Number of Residues | 26 |
| Details | binding site for residue ADP D 609 |
| Chain | Residue |
| D | LYS125 |
| D | ILE172 |
| D | LYS174 |
| D | CYS179 |
| D | GLN180 |
| D | GLY181 |
| D | ILE184 |
| D | GLN202 |
| D | LEU203 |
| D | TYR204 |
| D | ILE205 |
| D | LYS215 |
| D | ASP217 |
| D | LEU262 |
| D | THR263 |
| D | ASN264 |
| D | ASP346 |
| D | LEU348 |
| D | LEU358 |
| D | GLU359 |
| D | RZP608 |
| D | MG610 |
| D | MG611 |
| D | HOH742 |
| D | HOH749 |
| D | HOH757 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 610 |
| Chain | Residue |
| D | ASP346 |
| D | GLU359 |
| D | RZP608 |
| D | ADP609 |
| D | MG611 |
| D | HOH749 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 611 |
| Chain | Residue |
| D | GLU359 |
| D | ASN361 |
| D | RZP608 |
| D | ADP609 |
| D | MG610 |
| D | HOH742 |
| site_id | AF8 |
| Number of Residues | 1 |
| Details | binding site for residue CL D 612 |
| Chain | Residue |
| D | LYS374 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 686 |
| Details | Domain: {"description":"TTL","evidences":[{"source":"PROSITE-ProRule","id":"PRU00568","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 237 |
| Details | Region: {"description":"c-MTBD region","evidences":[{"source":"UniProtKB","id":"Q8N841","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6VZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Site: {"description":"Essential for specifying alpha-elongation versus initiation step of the polyglutamylase activity","evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for specifying alpha-elongation versus initiation step of the polyglutamylase activity","evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
