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6VZL

Crystal structure of human PPARgamma ligand binding domain in complex with GW1929

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue EDK A 501
ChainResidue
APHE282
ASER342
APHE363
AMET364
AHIS449
ALEU469
ATYR473
AHOH675
AHOH716
AHOH754
ACYS285
AGLN286
AARG288
ASER289
AHIS323
ATYR327
ALEU330
ALEU333

site_idAC2
Number of Residues12
Detailsbinding site for residue EDK B 501
ChainResidue
AHOH748
BARG280
BGLY284
BCYS285
BPHE287
BARG288
BSER289
BILE326
BLEU330
BILE341
BSER342
BGLU343

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
AGLN286
AHIS323
AHIS449
ATYR473
BGLN286
BHIS323
BHIS449
BTYR473

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224
BLYS224

226707

PDB entries from 2024-10-30

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