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6VTM

Human Cathepsin-G Inhibited by S. aureus EapH1

Functional Information from GO Data
ChainGOidnamespacecontents
A0002003biological_processangiotensin maturation
A0002548biological_processmonocyte chemotaxis
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006468biological_processprotein phosphorylation
A0006508biological_processproteolysis
A0006935biological_processchemotaxis
A0006955biological_processimmune response
A0008201molecular_functionheparin binding
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0010494cellular_componentcytoplasmic stress granule
A0016020cellular_componentmembrane
A0016485biological_processprotein processing
A0019221biological_processcytokine-mediated signaling pathway
A0019538biological_processprotein metabolic process
A0019731biological_processantibacterial humoral response
A0022617biological_processextracellular matrix disassembly
A0030141cellular_componentsecretory granule
A0030168biological_processplatelet activation
A0032496biological_processresponse to lipopolysaccharide
A0035578cellular_componentazurophil granule lumen
A0035590biological_processpurinergic nucleotide receptor signaling pathway
A0042119biological_processneutrophil activation
A0042742biological_processdefense response to bacterium
A0043231cellular_componentintracellular membrane-bounded organelle
A0048018molecular_functionreceptor ligand activity
A0050778biological_processpositive regulation of immune response
A0050829biological_processdefense response to Gram-negative bacterium
A0050830biological_processdefense response to Gram-positive bacterium
A0050832biological_processdefense response to fungus
A0050868biological_processnegative regulation of T cell activation
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070946biological_processneutrophil-mediated killing of gram-positive bacterium
A0071222biological_processcellular response to lipopolysaccharide
A0089720molecular_functioncaspase binding
A0098786biological_processbiofilm matrix disassembly
A1901731biological_processpositive regulation of platelet aggregation
B0005576cellular_componentextracellular region
C0002003biological_processangiotensin maturation
C0002548biological_processmonocyte chemotaxis
C0004252molecular_functionserine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006468biological_processprotein phosphorylation
C0006508biological_processproteolysis
C0006935biological_processchemotaxis
C0006955biological_processimmune response
C0008201molecular_functionheparin binding
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0010494cellular_componentcytoplasmic stress granule
C0016020cellular_componentmembrane
C0016485biological_processprotein processing
C0019221biological_processcytokine-mediated signaling pathway
C0019538biological_processprotein metabolic process
C0019731biological_processantibacterial humoral response
C0022617biological_processextracellular matrix disassembly
C0030141cellular_componentsecretory granule
C0030168biological_processplatelet activation
C0032496biological_processresponse to lipopolysaccharide
C0035578cellular_componentazurophil granule lumen
C0035590biological_processpurinergic nucleotide receptor signaling pathway
C0042119biological_processneutrophil activation
C0042742biological_processdefense response to bacterium
C0043231cellular_componentintracellular membrane-bounded organelle
C0048018molecular_functionreceptor ligand activity
C0050778biological_processpositive regulation of immune response
C0050829biological_processdefense response to Gram-negative bacterium
C0050830biological_processdefense response to Gram-positive bacterium
C0050832biological_processdefense response to fungus
C0050868biological_processnegative regulation of T cell activation
C0062023cellular_componentcollagen-containing extracellular matrix
C0070062cellular_componentextracellular exosome
C0070946biological_processneutrophil-mediated killing of gram-positive bacterium
C0071222biological_processcellular response to lipopolysaccharide
C0089720molecular_functioncaspase binding
C0098786biological_processbiofilm matrix disassembly
C1901731biological_processpositive regulation of platelet aggregation
D0002003biological_processangiotensin maturation
D0002548biological_processmonocyte chemotaxis
D0004252molecular_functionserine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006468biological_processprotein phosphorylation
D0006508biological_processproteolysis
D0006935biological_processchemotaxis
D0006955biological_processimmune response
D0008201molecular_functionheparin binding
D0008233molecular_functionpeptidase activity
D0008236molecular_functionserine-type peptidase activity
D0010494cellular_componentcytoplasmic stress granule
D0016020cellular_componentmembrane
D0016485biological_processprotein processing
D0019221biological_processcytokine-mediated signaling pathway
D0019538biological_processprotein metabolic process
D0019731biological_processantibacterial humoral response
D0022617biological_processextracellular matrix disassembly
D0030141cellular_componentsecretory granule
D0030168biological_processplatelet activation
D0032496biological_processresponse to lipopolysaccharide
D0035578cellular_componentazurophil granule lumen
D0035590biological_processpurinergic nucleotide receptor signaling pathway
D0042119biological_processneutrophil activation
D0042742biological_processdefense response to bacterium
D0043231cellular_componentintracellular membrane-bounded organelle
D0048018molecular_functionreceptor ligand activity
D0050778biological_processpositive regulation of immune response
D0050829biological_processdefense response to Gram-negative bacterium
D0050830biological_processdefense response to Gram-positive bacterium
D0050832biological_processdefense response to fungus
D0050868biological_processnegative regulation of T cell activation
D0062023cellular_componentcollagen-containing extracellular matrix
D0070062cellular_componentextracellular exosome
D0070946biological_processneutrophil-mediated killing of gram-positive bacterium
D0071222biological_processcellular response to lipopolysaccharide
D0089720molecular_functioncaspase binding
D0098786biological_processbiofilm matrix disassembly
D1901731biological_processpositive regulation of platelet aggregation
E0005576cellular_componentextracellular region
F0005576cellular_componentextracellular region
G0002003biological_processangiotensin maturation
G0002548biological_processmonocyte chemotaxis
G0004252molecular_functionserine-type endopeptidase activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005764cellular_componentlysosome
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006468biological_processprotein phosphorylation
G0006508biological_processproteolysis
G0006935biological_processchemotaxis
G0006955biological_processimmune response
G0008201molecular_functionheparin binding
G0008233molecular_functionpeptidase activity
G0008236molecular_functionserine-type peptidase activity
G0010494cellular_componentcytoplasmic stress granule
G0016020cellular_componentmembrane
G0016485biological_processprotein processing
G0019221biological_processcytokine-mediated signaling pathway
G0019538biological_processprotein metabolic process
G0019731biological_processantibacterial humoral response
G0022617biological_processextracellular matrix disassembly
G0030141cellular_componentsecretory granule
G0030168biological_processplatelet activation
G0032496biological_processresponse to lipopolysaccharide
G0035578cellular_componentazurophil granule lumen
G0035590biological_processpurinergic nucleotide receptor signaling pathway
G0042119biological_processneutrophil activation
G0042742biological_processdefense response to bacterium
G0043231cellular_componentintracellular membrane-bounded organelle
G0048018molecular_functionreceptor ligand activity
G0050778biological_processpositive regulation of immune response
G0050829biological_processdefense response to Gram-negative bacterium
G0050830biological_processdefense response to Gram-positive bacterium
G0050832biological_processdefense response to fungus
G0050868biological_processnegative regulation of T cell activation
G0062023cellular_componentcollagen-containing extracellular matrix
G0070062cellular_componentextracellular exosome
G0070946biological_processneutrophil-mediated killing of gram-positive bacterium
G0071222biological_processcellular response to lipopolysaccharide
G0089720molecular_functioncaspase binding
G0098786biological_processbiofilm matrix disassembly
G1901731biological_processpositive regulation of platelet aggregation
H0005576cellular_componentextracellular region
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue SO4 A 301
ChainResidue
ASER146
AARG148
AARG149
GARG163
GARG165
GGLN166
GHOH414

site_idAC2
Number of Residues4
Detailsbinding site for residue SO4 A 302
ChainResidue
GARG163
GHOH489
AMET147
AARG188

site_idAC3
Number of Residues4
Detailsbinding site for residue SO4 A 303
ChainResidue
AARG185
AHOH443
GARG132
GASN203

site_idAC4
Number of Residues7
Detailsbinding site for residue SO4 A 304
ChainResidue
AARG149
AARG188
AHOH409
AHOH469
AHOH470
GARG163
GARG165

site_idAC5
Number of Residues7
Detailsbinding site for residue SO4 C 301
ChainResidue
CARG20
CGLU21
CARG155
CHOH412
CHOH438
ETHR107
ELYS134

site_idAC6
Number of Residues7
Detailsbinding site for residue SO4 C 302
ChainResidue
CARG149
CARG155
CHOH438
CHOH472
CHOH476
CHOH531
ELYS134

site_idAC7
Number of Residues4
Detailsbinding site for residue SO4 C 303
ChainResidue
CARG27
CTHR138
CASN204
DARG149

site_idAC8
Number of Residues4
Detailsbinding site for residue SO4 C 304
ChainResidue
CARG163
CASP164
CARG165
CHOH428

site_idAC9
Number of Residues3
Detailsbinding site for residue SO4 C 305
ChainResidue
CTRP61
CARG91
GARG91

site_idAD1
Number of Residues5
Detailsbinding site for residue SO4 D 301
ChainResidue
CARG23
DSER146
DMET147
DARG148
DARG188

site_idAD2
Number of Residues3
Detailsbinding site for residue SO4 D 302
ChainResidue
DARG126
DALA127
DARG234

site_idAD3
Number of Residues9
Detailsbinding site for residue SO4 E 201
ChainResidue
CARG20
DARG144
DMET147
DLYS193
EPRO48
EARG61
EGLN135
EHOH303
EHOH307

site_idAD4
Number of Residues3
Detailsbinding site for residue SO4 G 301
ChainResidue
GARG163
GASP164
GARG165

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
ALEU55-CYS60

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. AAfkGDSGGPLL
ChainResidueDetails
AALA190-LEU201

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU00274
ChainResidueDetails
AHIS59
GHIS59
GASP103
GSER196
AASP103
ASER196
CHIS59
CASP103
CSER196
DHIS59
DASP103
DSER196

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) (paucimannose) asparagine; alternate => ECO:0000269|PubMed:26274980
ChainResidueDetails
AASN66
CASN66
DASN66
GASN66

219140

PDB entries from 2024-05-01

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