6VTK

Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a desensitized state at low pH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0007269	biological_process	neurotransmitter secretion
A	0015280	molecular_function	ligand-gated sodium channel activity
A	0016020	cellular_component	membrane
A	0030425	cellular_component	dendrite
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0045211	cellular_component	postsynaptic membrane
A	0071467	biological_process	cellular response to pH
A	0098662	biological_process	inorganic cation transmembrane transport
A	0098793	cellular_component	presynapse
A	0098978	cellular_component	glutamatergic synapse
A	0160128	molecular_function	pH-gated monoatomic ion channel activity
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0007269	biological_process	neurotransmitter secretion
B	0015280	molecular_function	ligand-gated sodium channel activity
B	0016020	cellular_component	membrane
B	0030425	cellular_component	dendrite
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0045211	cellular_component	postsynaptic membrane
B	0071467	biological_process	cellular response to pH
B	0098662	biological_process	inorganic cation transmembrane transport
B	0098793	cellular_component	presynapse
B	0098978	cellular_component	glutamatergic synapse
B	0160128	molecular_function	pH-gated monoatomic ion channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0007269	biological_process	neurotransmitter secretion
C	0015280	molecular_function	ligand-gated sodium channel activity
C	0016020	cellular_component	membrane
C	0030425	cellular_component	dendrite
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0045211	cellular_component	postsynaptic membrane
C	0071467	biological_process	cellular response to pH
C	0098662	biological_process	inorganic cation transmembrane transport
C	0098793	cellular_component	presynapse
C	0098978	cellular_component	glutamatergic synapse
C	0160128	molecular_function	pH-gated monoatomic ion channel activity

Functional Information from PROSITE/UniProt

site_id	PS01206
Number of Residues	21
Details	ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC

Chain	Residue	Details
A	TYR304-CYS324

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	63
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4NTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1056
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4NTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	87
Details	Transmembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4NTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Motif: {"description":"GAS motif; ion selectivity filter","evidences":[{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Site: {"description":"Involved in channel desensitization; the process by which the channel becomes unresponsive to proton stimulation","evidences":[{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Site: {"description":"Involved in proton-dependent gating","evidences":[{"source":"UniProtKB","id":"P78348","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17882215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22760635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QTS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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