6VTK

Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a desensitized state at low pH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0007269	biological_process	neurotransmitter secretion
A	0015280	molecular_function	ligand-gated sodium channel activity
A	0016020	cellular_component	membrane
A	0030425	cellular_component	dendrite
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0045202	cellular_component	synapse
A	0045211	cellular_component	postsynaptic membrane
A	0071467	biological_process	cellular response to pH
A	0098662	biological_process	inorganic cation transmembrane transport
A	0098793	cellular_component	presynapse
A	0098978	cellular_component	glutamatergic synapse
A	0160128	molecular_function	pH-gated monoatomic ion channel activity
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0007269	biological_process	neurotransmitter secretion
B	0015280	molecular_function	ligand-gated sodium channel activity
B	0016020	cellular_component	membrane
B	0030425	cellular_component	dendrite
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0042995	cellular_component	cell projection
B	0045202	cellular_component	synapse
B	0045211	cellular_component	postsynaptic membrane
B	0071467	biological_process	cellular response to pH
B	0098662	biological_process	inorganic cation transmembrane transport
B	0098793	cellular_component	presynapse
B	0098978	cellular_component	glutamatergic synapse
B	0160128	molecular_function	pH-gated monoatomic ion channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0007269	biological_process	neurotransmitter secretion
C	0015280	molecular_function	ligand-gated sodium channel activity
C	0016020	cellular_component	membrane
C	0030425	cellular_component	dendrite
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0042995	cellular_component	cell projection
C	0045202	cellular_component	synapse
C	0045211	cellular_component	postsynaptic membrane
C	0071467	biological_process	cellular response to pH
C	0098662	biological_process	inorganic cation transmembrane transport
C	0098793	cellular_component	presynapse
C	0098978	cellular_component	glutamatergic synapse
C	0160128	molecular_function	pH-gated monoatomic ion channel activity

Functional Information from PROSITE/UniProt

site_id	PS01206
Number of Residues	21
Details	ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC

Chain	Residue	Details
A	TYR304-CYS324

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:24507937, ECO:0007744|PDB:4NTW

Chain	Residue	Details
A	MET1-LEU49
A	TYR455-CYS527
C	MET1-LEU49
C	TYR455-CYS527
B	MET1-LEU49
B	TYR455-CYS527

---

site_id	SWS_FT_FI2
Number of Residues	63
Details	TRANSMEM: Helical => ECO:0000305|PubMed:24507937, ECO:0007744|PDB:4NTW

Chain	Residue	Details
A	CYS50-LEU71
C	CYS50-LEU71
B	CYS50-LEU71

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site_id	SWS_FT_FI3
Number of Residues	1056
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:24507937, ECO:0007744|PDB:4NTW

Chain	Residue	Details
A	TYR72-ALA424
C	TYR72-ALA424
B	TYR72-ALA424

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site_id	SWS_FT_FI4
Number of Residues	87
Details	TRANSMEM: Discontinuously helical => ECO:0000305|PubMed:24507937, ECO:0007744|PDB:4NTW

Chain	Residue	Details
A	TYR425-ASP454
C	TYR425-ASP454
B	TYR425-ASP454

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site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Involved in channel desensitization; the process by which the channel becomes unresponsive to proton stimulation => ECO:0000269|PubMed:22842900

Chain	Residue	Details
A	GLU80
C	GLU80
B	GLU80

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site_id	SWS_FT_FI6
Number of Residues	3
Details	SITE: Involved in proton-dependent gating => ECO:0000250|UniProtKB:P78348

Chain	Residue	Details
A	ASP356
C	ASP356
B	ASP356

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site_id	SWS_FT_FI7
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17882215, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900, ECO:0007744|PDB:2QTS

Chain	Residue	Details
A	ASN367
A	ASN394
C	ASN367
C	ASN394
B	ASN367
B	ASN394

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