6VTK

Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a desensitized state at low pH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006814	biological_process	sodium ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0015280	molecular_function	ligand-gated sodium channel activity
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0070207	biological_process	protein homotrimerization
A	0071467	biological_process	cellular response to pH
A	0160128	molecular_function	pH-gated monoatomic ion channel activity
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006814	biological_process	sodium ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0015280	molecular_function	ligand-gated sodium channel activity
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0070207	biological_process	protein homotrimerization
B	0071467	biological_process	cellular response to pH
B	0160128	molecular_function	pH-gated monoatomic ion channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006814	biological_process	sodium ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0015280	molecular_function	ligand-gated sodium channel activity
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0070207	biological_process	protein homotrimerization
C	0071467	biological_process	cellular response to pH
C	0160128	molecular_function	pH-gated monoatomic ion channel activity

Functional Information from PROSITE/UniProt

site_id	PS01206
Number of Residues	21
Details	ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC

Chain	Residue	Details
A	TYR304-CYS324

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	354
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
A	MET1-VAL46
A	ASP454-CYS527
C	MET1-VAL46
C	ASP454-CYS527
B	MET1-VAL46
B	ASP454-CYS527

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site_id	SWS_FT_FI2
Number of Residues	69
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TRP47-PHE70
C	TRP47-PHE70
B	TRP47-PHE70

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site_id	SWS_FT_FI3
Number of Residues	1065
Details	TOPO_DOM: Extracellular

Chain	Residue	Details
A	LEU71-GLU426
C	LEU71-GLU426
B	LEU71-GLU426

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site_id	SWS_FT_FI4
Number of Residues	78
Details	TRANSMEM: Discontinuously helical

Chain	Residue	Details
A	VAL427-PHE453
C	VAL427-PHE453
B	VAL427-PHE453

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site_id	SWS_FT_FI5
Number of Residues	6
Details	SITE: Important for channel gating

Chain	Residue	Details
A	TYR72
A	TRP288
C	TYR72
C	TRP288
B	TYR72
B	TRP288

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site_id	SWS_FT_FI6
Number of Residues	3
Details	SITE: Important for channel desensitizing

Chain	Residue	Details
A	GLU80
C	GLU80
B	GLU80

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site_id	SWS_FT_FI7
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17882215, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900

Chain	Residue	Details
A	ASN367
A	ASN394
C	ASN367
C	ASN394
B	ASN367
B	ASN394

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