6VS8
Mycobacterium tuberculosis dihydrofolate reductase in complex with ethyl 2-methyl thiazole-4-carboxylate(fragment 3)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070401 | molecular_function | NADP+ binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0044281 | biological_process | small molecule metabolic process |
| B | 0046452 | biological_process | dihydrofolate metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046655 | biological_process | folic acid metabolic process |
| B | 0050661 | molecular_function | NADP binding |
| B | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CO A 201 |
| Chain | Residue |
| A | HIS38 |
| A | HOH316 |
| A | HOH351 |
| A | HOH357 |
| A | HOH393 |
| B | HIS157 |
| site_id | AC2 |
| Number of Residues | 35 |
| Details | binding site for residue NAP A 202 |
| Chain | Residue |
| A | GLY15 |
| A | ARG16 |
| A | GLY18 |
| A | ASP19 |
| A | ILE20 |
| A | GLY43 |
| A | ARG44 |
| A | ARG45 |
| A | THR46 |
| A | LEU65 |
| A | SER66 |
| A | ARG67 |
| A | GLY80 |
| A | ILE94 |
| A | GLY96 |
| A | GLY97 |
| A | GLN98 |
| A | VAL99 |
| A | TYR100 |
| A | LEU102 |
| A | RJY204 |
| A | HOH311 |
| A | HOH314 |
| A | HOH336 |
| A | HOH341 |
| A | HOH342 |
| A | HOH364 |
| A | HOH375 |
| A | HOH378 |
| A | HOH395 |
| A | HOH402 |
| A | HOH416 |
| A | TRP6 |
| A | ALA7 |
| A | ILE14 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 A 203 |
| Chain | Residue |
| A | ARG44 |
| A | ARG45 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue RJY A 204 |
| Chain | Residue |
| A | ASP27 |
| A | GLN28 |
| A | PHE31 |
| A | THR46 |
| A | LEU50 |
| A | NAP202 |
| A | HOH307 |
| A | HOH315 |
| A | HOH327 |
| A | HOH342 |
| A | HOH450 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 205 |
| Chain | Residue |
| A | ARG67 |
| A | HOH347 |
| A | HOH389 |
| B | HOH344 |
| B | HOH365 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue CO B 201 |
| Chain | Residue |
| A | HOH352 |
| B | HIS38 |
| B | HOH315 |
| B | HOH321 |
| B | HOH337 |
| B | HOH381 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 203 |
| Chain | Residue |
| B | GLN28 |
| B | PHE31 |
| B | ARG32 |
| B | ARG60 |
| B | HOH301 |
| B | HOH305 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 204 |
| Chain | Residue |
| B | ARG44 |
| B | ARG45 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue RJY B 205 |
| Chain | Residue |
| B | ASP27 |
| B | GLN28 |
| B | PHE31 |
| B | LEU50 |
| B | ILE94 |
| B | NAP202 |
| B | HOH357 |
| B | HOH371 |
| B | HOH403 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 206 |
| Chain | Residue |
| B | GLU26 |
| B | ALA29 |
| B | ARG146 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 207 |
| Chain | Residue |
| A | ARG23 |
| A | HOH320 |
| A | HOH460 |
| A | HOH461 |
| B | ARG32 |
| site_id | AD3 |
| Number of Residues | 36 |
| Details | binding site for residues NAP B 202 and SO4 B 208 |
| Chain | Residue |
| B | GLY43 |
| B | ARG44 |
| B | ARG45 |
| B | THR46 |
| B | LEU65 |
| B | SER66 |
| B | ARG67 |
| B | GLN68 |
| B | GLY80 |
| B | ILE94 |
| B | GLY96 |
| B | GLY97 |
| B | GLN98 |
| B | VAL99 |
| B | TYR100 |
| B | RJY205 |
| B | HOH334 |
| B | HOH341 |
| B | HOH344 |
| B | HOH348 |
| B | HOH352 |
| B | HOH357 |
| B | HOH358 |
| B | HOH361 |
| B | HOH365 |
| B | HOH377 |
| B | HOH382 |
| A | HOH336 |
| B | TRP6 |
| B | ALA7 |
| B | ILE14 |
| B | GLY15 |
| B | ARG16 |
| B | GLY18 |
| B | ASP19 |
| B | ILE20 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrggdIPWrlpe.DqahFreiT |
| Chain | Residue | Details |
| A | VAL13-THR35 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | Binding site: {} |
| Chain | Residue | Details |
