Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VRA

Anthrax octamer prechannel bound to full-length edema factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0051260	biological_process	protein homooligomerization
B	0005576	cellular_component	extracellular region
B	0051260	biological_process	protein homooligomerization
C	0005576	cellular_component	extracellular region
C	0051260	biological_process	protein homooligomerization
D	0005576	cellular_component	extracellular region
D	0051260	biological_process	protein homooligomerization
E	0005576	cellular_component	extracellular region
E	0051260	biological_process	protein homooligomerization
F	0005576	cellular_component	extracellular region
F	0051260	biological_process	protein homooligomerization
G	0005576	cellular_component	extracellular region
G	0051260	biological_process	protein homooligomerization
H	0005576	cellular_component	extracellular region
H	0051260	biological_process	protein homooligomerization
I	0000166	molecular_function	nucleotide binding
I	0003824	molecular_function	catalytic activity
I	0004016	molecular_function	adenylate cyclase activity
I	0005516	molecular_function	calmodulin binding
I	0005524	molecular_function	ATP binding
I	0005576	cellular_component	extracellular region
I	0006171	biological_process	cAMP biosynthetic process
I	0008237	molecular_function	metallopeptidase activity
I	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
I	0010856	molecular_function	adenylate cyclase activator activity
I	0016829	molecular_function	lyase activity
I	0032564	molecular_function	dATP binding
I	0044164	cellular_component	host cell cytosol
I	0046872	molecular_function	metal ion binding
I	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
I	0090729	molecular_function	toxin activity
I	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
I	1902494	cellular_component	catalytic complex
J	0000166	molecular_function	nucleotide binding
J	0003824	molecular_function	catalytic activity
J	0004016	molecular_function	adenylate cyclase activity
J	0005516	molecular_function	calmodulin binding
J	0005524	molecular_function	ATP binding
J	0005576	cellular_component	extracellular region
J	0006171	biological_process	cAMP biosynthetic process
J	0008237	molecular_function	metallopeptidase activity
J	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
J	0010856	molecular_function	adenylate cyclase activator activity
J	0016829	molecular_function	lyase activity
J	0032564	molecular_function	dATP binding
J	0044164	cellular_component	host cell cytosol
J	0046872	molecular_function	metal ion binding
J	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
J	0090729	molecular_function	toxin activity
J	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
J	1902494	cellular_component	catalytic complex
K	0000166	molecular_function	nucleotide binding
K	0003824	molecular_function	catalytic activity
K	0004016	molecular_function	adenylate cyclase activity
K	0005516	molecular_function	calmodulin binding
K	0005524	molecular_function	ATP binding
K	0005576	cellular_component	extracellular region
K	0006171	biological_process	cAMP biosynthetic process
K	0008237	molecular_function	metallopeptidase activity
K	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
K	0010856	molecular_function	adenylate cyclase activator activity
K	0016829	molecular_function	lyase activity
K	0032564	molecular_function	dATP binding
K	0044164	cellular_component	host cell cytosol
K	0046872	molecular_function	metal ion binding
K	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
K	0090729	molecular_function	toxin activity
K	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
K	1902494	cellular_component	catalytic complex
L	0000166	molecular_function	nucleotide binding
L	0003824	molecular_function	catalytic activity
L	0004016	molecular_function	adenylate cyclase activity
L	0005516	molecular_function	calmodulin binding
L	0005524	molecular_function	ATP binding
L	0005576	cellular_component	extracellular region
L	0006171	biological_process	cAMP biosynthetic process
L	0008237	molecular_function	metallopeptidase activity
L	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
L	0010856	molecular_function	adenylate cyclase activator activity
L	0016829	molecular_function	lyase activity
L	0032564	molecular_function	dATP binding
L	0044164	cellular_component	host cell cytosol
L	0046872	molecular_function	metal ion binding
L	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
L	0090729	molecular_function	toxin activity
L	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
L	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA A 801

Chain	Residue
A	ASP177
A	ASP179
A	ASP181
A	ILE183
A	GLU188

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 802

Chain	Residue
A	LYS225
A	ASP235
A	ASP179
A	ASP181
A	GLU188
A	SER222

site_id	AC3
Number of Residues	5
Details	binding site for residue CA B 801

Chain	Residue
B	ASP177
B	ASP179
B	ASP181
B	ILE183
B	GLU188

site_id	AC4
Number of Residues	6
Details	binding site for residue CA B 802

Chain	Residue
B	ASP179
B	ASP181
B	GLU188
B	SER222
B	LYS225
B	ASP235

site_id	AC5
Number of Residues	5
Details	binding site for residue CA C 801

Chain	Residue
C	ASP177
C	ASP179
C	ASP181
C	ILE183
C	GLU188

site_id	AC6
Number of Residues	6
Details	binding site for residue CA C 802

Chain	Residue
C	ASP179
C	ASP181
C	GLU188
C	SER222
C	LYS225
C	ASP235

site_id	AC7
Number of Residues	5
Details	binding site for residue CA D 801

Chain	Residue
D	ASP177
D	ASP179
D	ASP181
D	ILE183
D	GLU188

site_id	AC8
Number of Residues	6
Details	binding site for residue CA D 802

Chain	Residue
D	ASP179
D	ASP181
D	GLU188
D	SER222
D	LYS225
D	ASP235

site_id	AC9
Number of Residues	5
Details	binding site for residue CA E 801

Chain	Residue
E	ASP177
E	ASP179
E	ASP181
E	ILE183
E	GLU188

site_id	AD1
Number of Residues	6
Details	binding site for residue CA E 802

Chain	Residue
E	ASP179
E	ASP181
E	GLU188
E	SER222
E	LYS225
E	ASP235

site_id	AD2
Number of Residues	5
Details	binding site for residue CA F 801

Chain	Residue
F	ASP177
F	ASP179
F	ASP181
F	ILE183
F	GLU188

site_id	AD3
Number of Residues	6
Details	binding site for residue CA F 802

Chain	Residue
F	ASP179
F	ASP181
F	GLU188
F	SER222
F	LYS225
F	ASP235

site_id	AD4
Number of Residues	5
Details	binding site for residue CA G 801

Chain	Residue
G	ASP177
G	ASP179
G	ASP181
G	ILE183
G	GLU188

site_id	AD5
Number of Residues	6
Details	binding site for residue CA G 802

Chain	Residue
G	ASP179
G	ASP181
G	GLU188
G	SER222
G	LYS225
G	ASP235

site_id	AD6
Number of Residues	5
Details	binding site for residue CA H 801

Chain	Residue
H	ASP177
H	ASP179
H	ASP181
H	ILE183
H	GLU188

site_id	AD7
Number of Residues	6
Details	binding site for residue CA H 802

Chain	Residue
H	ASP179
H	ASP181
H	GLU188
H	SER222
H	LYS225
H	ASP235

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Region: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	856
Details	Region: {"description":"Domain 3, heptamerization","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1112
Details	Region: {"description":"Domain 4, binding to the receptor","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	32
Details	Site: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Site: {"description":"Phi-clamp","evidences":[{"source":"PubMed","id":"16051798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	8
Details	Site: {"description":"Essential for binding to cell receptor","evidences":[{"source":"PubMed","id":"12771151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	852
Details	Domain: {"description":"ATLF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	556
Details	Region: {"description":"Catalytic CB","evidences":[{"source":"PubMed","id":"11807546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	528
Details	Region: {"description":"Catalytic CA2","evidences":[{"source":"PubMed","id":"11807546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11807546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15719022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y0V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15719022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XFW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)