Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VPQ

Crystal structure of the C-terminal domain of DENR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001731	biological_process	formation of translation preinitiation complex
A	0002188	biological_process	translation reinitiation
A	0003743	molecular_function	translation initiation factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0032790	biological_process	ribosome disassembly
A	0075522	biological_process	IRES-dependent viral translational initiation
B	0001731	biological_process	formation of translation preinitiation complex
B	0002188	biological_process	translation reinitiation
B	0003743	molecular_function	translation initiation factor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0032790	biological_process	ribosome disassembly
B	0075522	biological_process	IRES-dependent viral translational initiation
C	0001731	biological_process	formation of translation preinitiation complex
C	0002188	biological_process	translation reinitiation
C	0003743	molecular_function	translation initiation factor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0032790	biological_process	ribosome disassembly
C	0075522	biological_process	IRES-dependent viral translational initiation
D	0001731	biological_process	formation of translation preinitiation complex
D	0002188	biological_process	translation reinitiation
D	0003743	molecular_function	translation initiation factor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0032790	biological_process	ribosome disassembly
D	0075522	biological_process	IRES-dependent viral translational initiation
E	0001731	biological_process	formation of translation preinitiation complex
E	0002188	biological_process	translation reinitiation
E	0003743	molecular_function	translation initiation factor activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0032790	biological_process	ribosome disassembly
E	0075522	biological_process	IRES-dependent viral translational initiation
F	0001731	biological_process	formation of translation preinitiation complex
F	0002188	biological_process	translation reinitiation
F	0003743	molecular_function	translation initiation factor activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0032790	biological_process	ribosome disassembly
F	0075522	biological_process	IRES-dependent viral translational initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 201

Chain	Residue
A	THR171
A	ASP172
A	HOH308
A	HOH325
A	HOH352
C	LYS119

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 202

Chain	Residue
A	ASP176
A	GLN179

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 203

Chain	Residue
A	PGE205
A	HOH346
A	HOH366
A	HOH373
A	GLU191

site_id	AC4
Number of Residues	8
Details	binding site for residue PGE A 204

Chain	Residue
A	ILE120
A	ARG130
A	GLU163
A	ILE165
A	HOH318
A	HOH371
B	ARG130
C	PGE202

site_id	AC5
Number of Residues	7
Details	binding site for residue PGE A 205

Chain	Residue
A	ASP187
A	ASP188
A	ILE190
A	GLU191
A	MG203
A	HOH319
A	HOH346

site_id	AC6
Number of Residues	7
Details	binding site for residue MG A 206

Chain	Residue
A	ASP173
A	HOH304
A	HOH315
A	HOH368
E	HOH336
E	HOH360
E	HOH369

site_id	AC7
Number of Residues	6
Details	binding site for residue ACT A 207

Chain	Residue
A	SER153
A	GLY155
A	HOH309
D	GLU143
D	ARG146
D	HOH342

site_id	AC8
Number of Residues	6
Details	binding site for residue MG B 201

Chain	Residue
B	PRO183
B	GLU184
B	PGE206
C	ALA149
C	SER153
F	LYS126

site_id	AC9
Number of Residues	5
Details	binding site for residue MG B 202

Chain	Residue
B	ASP187
B	ILE190
B	HOH363
E	ASP188
E	HOH303

site_id	AD1
Number of Residues	3
Details	binding site for residue MG B 203

Chain	Residue
B	ALA149
B	GLN150
B	SER153

site_id	AD2
Number of Residues	5
Details	binding site for residue MG B 204

Chain	Residue
B	LYS142
B	GLN145
B	HOH354
B	HOH356
B	HOH376

site_id	AD3
Number of Residues	4
Details	binding site for residue MG B 205

Chain	Residue
B	ASP176
B	GLN179
B	HOH319
B	HOH352

site_id	AD4
Number of Residues	9
Details	binding site for residue PGE B 206

Chain	Residue
B	ILE139
B	ASP140
B	GLU143
B	LYS181
B	TRP182
B	MG201
C	SER153
E	ARG122
F	LYS126

site_id	AD5
Number of Residues	8
Details	binding site for residue PGE B 207

Chain	Residue
B	PRO121
B	LYS124
B	GLY155
B	ALA156
B	SER157
B	GLN167
B	HOH341
C	TYR127

site_id	AD6
Number of Residues	2
Details	binding site for residue CA B 208

Chain	Residue
B	GLU180
C	HOH350

site_id	AD7
Number of Residues	3
Details	binding site for residue MG C 201

Chain	Residue
C	ASP187
D	HOH317
E	HOH363

site_id	AD8
Number of Residues	8
Details	binding site for residue PGE C 202

Chain	Residue
A	ARG122
A	ALA123
A	PGE204
B	ARG122
C	PRO121
C	ARG122
C	ALA123
C	HOH301

site_id	AD9
Number of Residues	7
Details	binding site for residue PGE C 203

Chain	Residue
F	TYR127
F	HOH323
C	LYS151
C	PHE152
C	HOH310
C	HOH325
C	HOH377

site_id	AE1
Number of Residues	6
Details	binding site for residue PGE C 204

Chain	Residue
B	LYS119
C	THR171
C	ASP172
C	GLU195
C	HOH313
C	HOH317

site_id	AE2
Number of Residues	6
Details	binding site for residue MG C 205

Chain	Residue
C	ASP187
C	ILE190
C	HOH358
C	HOH366
C	HOH368
C	HOH369

site_id	AE3
Number of Residues	5
Details	binding site for residue CA C 206

Chain	Residue
A	HOH378
C	GLY160
C	GLU163
C	HOH340
C	HOH359

site_id	AE4
Number of Residues	4
Details	binding site for residue MG D 201

Chain	Residue
B	HOH349
D	GLU138
D	HOH314
D	HOH365

site_id	AE5
Number of Residues	17
Details	binding site for residue PGE D 202

Chain	Residue
D	ILE120
D	PRO121
D	ARG122
D	ALA123
D	HOH301
D	HOH304
D	HOH311
D	HOH315
D	HOH337
D	HOH348
D	HOH350
E	PRO121
E	ALA123
F	ILE120
F	PRO121
F	ARG122
F	ALA123

site_id	AE6
Number of Residues	5
Details	binding site for residue MG D 203

Chain	Residue
C	HOH316
C	HOH349
D	HOH334
D	HOH375
E	HOH357

site_id	AE7
Number of Residues	4
Details	binding site for residue CA D 204

Chain	Residue
D	HOH305
D	HOH330
F	ASP188
F	HOH315

site_id	AE8
Number of Residues	3
Details	binding site for residue MG E 201

Chain	Residue
E	ASP187
E	ILE190
E	HOH365

site_id	AE9
Number of Residues	2
Details	binding site for residue MG E 202

Chain	Residue
E	ASP176
E	GLN179

site_id	AF1
Number of Residues	3
Details	binding site for residue MG E 203

Chain	Residue
D	HOH372
E	GLU195
E	HOH352

site_id	AF2
Number of Residues	4
Details	binding site for residue PGE E 204

Chain	Residue
D	HOH325
E	CYS132
E	GLY133
E	ASP162

site_id	AF3
Number of Residues	7
Details	binding site for residue MG F 201

Chain	Residue
D	ASP176
D	HOH356
F	GLU191
F	MG203
F	HOH305
F	HOH334
F	HOH366

site_id	AF4
Number of Residues	4
Details	binding site for residue MG F 202

Chain	Residue
B	HOH364
D	LYS126
F	ARG122
F	LYS124

site_id	AF5
Number of Residues	7
Details	binding site for residue MG F 203

Chain	Residue
F	ASP187
F	ILE190
F	GLU191
F	MG201
F	HOH305
F	HOH324
F	HOH375

site_id	AF6
Number of Residues	6
Details	binding site for residue MG F 204

Chain	Residue
D	ASP176
D	GLU180
F	ASP188
F	GLU191
F	HOH312
F	HOH362

site_id	AF7
Number of Residues	4
Details	binding site for residue MG F 205

Chain	Residue
C	ASP172
C	ASP173
C	HOH320
F	GLU195

site_id	AF8
Number of Residues	8
Details	binding site for residue MG F 206

Chain	Residue
C	ASP173
C	HOH306
C	HOH348
F	THR171
F	ASP172
F	GLU195
F	MG207
F	HOH301

site_id	AF9
Number of Residues	5
Details	binding site for residue MG F 207

Chain	Residue
F	THR171
F	ASP192
F	GLU195
F	MG206
F	HOH301

site_id	AG1
Number of Residues	4
Details	binding site for residue PGE F 208

Chain	Residue
F	ASP187
F	ACT211
F	HOH309
F	HOH353

site_id	AG2
Number of Residues	7
Details	binding site for residue PGE F 209

Chain	Residue
F	PHE137
F	GLU138
F	ILE139
F	TRP182
F	GLU184
F	HOH304
F	HOH340

site_id	AG3
Number of Residues	7
Details	binding site for residue ACT F 210

Chain	Residue
F	LYS124
F	LYS125
F	CSO154
F	GLY155
F	GLN167
F	HOH310
F	HOH379

site_id	AG4
Number of Residues	6
Details	binding site for residue ACT F 211

Chain	Residue
F	GLN179
F	ASP187
F	PGE208
F	HOH308
F	HOH321
F	HOH353

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER20
B	SER20
C	SER20
D	SER20
E	SER20
F	SER20

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER73
B	SER73
C	SER73
D	SER73
E	SER73
F	SER73

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	THR86
B	THR86
C	THR86
D	THR86
E	THR86
F	THR86

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q9CQJ6

Chain	Residue	Details
A	SER189
B	SER189
C	SER189
D	SER189
E	SER189
F	SER189

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)