Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VP0

Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001523	biological_process	retinoid metabolic process
C	0003846	molecular_function	2-acylglycerol O-acyltransferase activity
C	0004144	molecular_function	diacylglycerol O-acyltransferase activity
C	0005515	molecular_function	protein binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006640	biological_process	monoacylglycerol biosynthetic process
C	0006641	biological_process	triglyceride metabolic process
C	0008374	molecular_function	O-acyltransferase activity
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0019432	biological_process	triglyceride biosynthetic process
C	0019915	biological_process	lipid storage
C	0034379	biological_process	very-low-density lipoprotein particle assembly
C	0035336	biological_process	long-chain fatty-acyl-CoA metabolic process
C	0035579	cellular_component	specific granule membrane
C	0042572	biological_process	retinol metabolic process
C	0042802	molecular_function	identical protein binding
C	0046339	biological_process	diacylglycerol metabolic process
C	0046486	biological_process	glycerolipid metabolic process
C	0050252	molecular_function	retinol O-fatty-acyltransferase activity
C	0055089	biological_process	fatty acid homeostasis
E	0001523	biological_process	retinoid metabolic process
E	0003846	molecular_function	2-acylglycerol O-acyltransferase activity
E	0004144	molecular_function	diacylglycerol O-acyltransferase activity
E	0005515	molecular_function	protein binding
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0006629	biological_process	lipid metabolic process
E	0006640	biological_process	monoacylglycerol biosynthetic process
E	0006641	biological_process	triglyceride metabolic process
E	0008374	molecular_function	O-acyltransferase activity
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0019432	biological_process	triglyceride biosynthetic process
E	0019915	biological_process	lipid storage
E	0034379	biological_process	very-low-density lipoprotein particle assembly
E	0035336	biological_process	long-chain fatty-acyl-CoA metabolic process
E	0035579	cellular_component	specific granule membrane
E	0042572	biological_process	retinol metabolic process
E	0042802	molecular_function	identical protein binding
E	0046339	biological_process	diacylglycerol metabolic process
E	0046486	biological_process	glycerolipid metabolic process
E	0050252	molecular_function	retinol O-fatty-acyltransferase activity
E	0055089	biological_process	fatty acid homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue POV C 601

Chain	Residue
C	LEU89
E	SER78
E	ILE88
E	TRP91
C	VAL93
C	PHE277
C	ARG280
C	ARG281
C	TYR339
C	POV604
E	PHE76
E	SER77

site_id	AC2
Number of Residues	5
Details	binding site for residue P5S C 602

Chain	Residue
C	MET314
C	TYR316
C	TRP429
C	THR432
C	ILE463

site_id	AC3
Number of Residues	6
Details	binding site for residue P5S C 603

Chain	Residue
C	LEU324
C	LYS325
C	VAL328
C	ILE463
C	AV0606
E	POV604

site_id	AC4
Number of Residues	9
Details	binding site for residue POV C 604

Chain	Residue
C	LEU96
C	SER99
C	ASN100
C	LEU291
C	ILE336
C	POV601
C	AV0606
E	P5S603
E	AV0606

site_id	AC5
Number of Residues	12
Details	binding site for residue 3VV C 605

Chain	Residue
C	TRP334
C	PHE338
C	TRP374
C	GLN375
C	TRP377
C	HIS382
C	ILE386
C	TYR390
C	LYS400
C	ARG404
C	SER411
C	HIS415

site_id	AC6
Number of Residues	8
Details	binding site for residue AV0 C 606

Chain	Residue
C	GLN290
C	LEU291
C	GLN298
C	TRP299
C	P5S603
C	POV604
E	POV604
E	AV0606

site_id	AC7
Number of Residues	12
Details	binding site for residue POV E 601

Chain	Residue
C	PHE76
C	SER77
C	SER78
C	ILE88
C	TRP91
E	LEU89
E	VAL93
E	PHE277
E	ARG280
E	ARG281
E	TYR339
E	POV604

site_id	AC8
Number of Residues	9
Details	binding site for residue P5S E 602

Chain	Residue
E	ASP313
E	MET314
E	TYR316
E	LEU324
E	TRP429
E	THR432
E	ILE463
E	GLY464
E	MET471

site_id	AC9
Number of Residues	5
Details	binding site for residue P5S E 603

Chain	Residue
C	POV604
E	LEU324
E	LYS325
E	VAL328
E	AV0606

site_id	AD1
Number of Residues	8
Details	binding site for residue POV E 604

Chain	Residue
C	P5S603
C	AV0606
E	LEU96
E	SER99
E	LEU291
E	ILE336
E	POV601
E	AV0606

site_id	AD2
Number of Residues	12
Details	binding site for residue 3VV E 605

Chain	Residue
E	TRP334
E	PHE338
E	TRP374
E	GLN375
E	TRP377
E	HIS382
E	ILE386
E	TYR390
E	LYS400
E	ARG404
E	SER411
E	HIS415

site_id	AD3
Number of Residues	7
Details	binding site for residue AV0 E 606

Chain	Residue
C	AV0606
E	ASN100
E	LEU103
E	GLN298
E	P5S603
E	POV604
C	POV604

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	100
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	74
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	22
Details	Region: {"description":"Extracellular loop 1 (EL1)","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	90
Details	Region: {"description":"Intracellular loop 2 (IL2)","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	28
Details	Region: {"description":"Amphipathic helix (AH)","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	12
Details	Motif: {"description":"FYXDWWN motif","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)