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6VN7

Cryo-EM structure of an activated VIP1 receptor-G protein complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0003091biological_processrenal water homeostasis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007190biological_processactivation of adenylate cyclase activity
A0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
A0007608biological_processsensory perception of smell
A0010856molecular_functionadenylate cyclase activator activity
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031748molecular_functionD1 dopamine receptor binding
A0032588cellular_componenttrans-Golgi network membrane
A0046872molecular_functionmetal ion binding
A0046907biological_processintracellular transport
A0048589biological_processdevelopmental growth
A0050796biological_processregulation of insulin secretion
A0050890biological_processcognition
A0060348biological_processbone development
A0060789biological_processhair follicle placode formation
A0070062cellular_componentextracellular exosome
A0070527biological_processplatelet aggregation
A0071377biological_processcellular response to glucagon stimulus
A0071380biological_processcellular response to prostaglandin E stimulus
A0071870biological_processcellular response to catecholamine stimulus
A0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
L0005179molecular_functionhormone activity
L0005184molecular_functionneuropeptide hormone activity
L0005576cellular_componentextracellular region
R0004888molecular_functiontransmembrane signaling receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0004999molecular_functionvasoactive intestinal polypeptide receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
R0008284biological_processpositive regulation of cell population proliferation
R0008528molecular_functionG protein-coupled peptide receptor activity
R0016020cellular_componentmembrane
R0017046molecular_functionpeptide hormone binding
R0043235cellular_componentreceptor complex
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue CLR R 601
ChainResidue
RTYR224
RSER267
RCLR606

site_idAC2
Number of Residues1
Detailsbinding site for residue CLR R 602
ChainResidue
RILE355

site_idAC3
Number of Residues1
Detailsbinding site for residue CLR R 604
ChainResidue
RILE278

site_idAC4
Number of Residues3
Detailsbinding site for residue CLR R 605
ChainResidue
RPHE269
RSER292
RTRP295

site_idAC5
Number of Residues4
Detailsbinding site for residue CLR R 606
ChainResidue
RPHE221
RTRP263
RCLR601
RHIS180

site_idAC6
Number of Residues2
Detailsbinding site for residue PLM R 609
ChainResidue
RTHR144
RGLY151

Functional Information from PROSITE/UniProt
site_idPS00260
Number of Residues23
DetailsGLUCAGON Glucagon / GIP / secretin / VIP family signature. HSDGIFtDSYsryrkqmaVKKYL
ChainResidueDetails
LHIS1-LEU23

site_idPS00649
Number of Residues25
DetailsG_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CskmWDnlt.CWpaTprgqvvvlaCP
ChainResidueDetails
RCYS63-PRO87

site_idPS00650
Number of Residues16
DetailsG_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGFVVaILYCFlNgeV
ChainResidueDetails
RGLN380-VAL395

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299
BVAL327-GLY341

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues158
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RALA31-VAL142
RLYS195-LYS216
RARG277-SER292
RASP362-GLU373
AASP223
AASN292
AALA366

site_idSWS_FT_FI2
Number of Residues24
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RLYS143-PHE167

site_idSWS_FT_FI3
Number of Residues43
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RARG168-ARG174
RTYR241-TYR254
RARG317-ARG341

site_idSWS_FT_FI4
Number of Residues19
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RASN175-ILE194

site_idSWS_FT_FI5
Number of Residues23
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RALA217-LEU240

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RPHE255-ALA276

site_idSWS_FT_FI7
Number of Residues23
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RLEU293-ILE316

site_idSWS_FT_FI8
Number of Residues19
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RSER342-PRO361

site_idSWS_FT_FI9
Number of Residues19
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RLEU374-GLY393

site_idSWS_FT_FI10
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN58
RASN69
RASN100
RASN290

222624

PDB entries from 2024-07-17

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