6VJU
Crystal Structure of Cystathionine beta synthase from Legionella pneumophila with LLP, PLP, and homocysteine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0004124 | molecular_function | cysteine synthase activity |
| B | 0006535 | biological_process | cysteine biosynthetic process from serine |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0019344 | biological_process | cysteine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | LEU15 |
| A | TYR56 |
| A | HOH803 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | GLU103 |
| A | LYS104 |
| A | MET105 |
| A | LYS311 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | LYS198 |
| A | HOH682 |
| A | HOH717 |
| A | ASN162 |
| A | TYR165 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 504 |
| Chain | Residue |
| A | LEU219 |
| A | GLY220 |
| A | GLY221 |
| A | ASN244 |
| A | HOH711 |
| A | HOH730 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue ACT A 505 |
| Chain | Residue |
| A | LLP51 |
| A | THR78 |
| A | SER79 |
| A | ASN81 |
| A | THR82 |
| A | GLN154 |
| A | HOH644 |
| A | HOH684 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | HIS20 |
| B | TYR11 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 507 |
| Chain | Residue |
| A | THR17 |
| A | GLY19 |
| A | HIS20 |
| A | THR21 |
| A | PHE44 |
| A | ASN45 |
| B | PHE44 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 508 |
| Chain | Residue |
| A | HIS20 |
| A | ASP174 |
| A | ASP175 |
| A | HOH675 |
| B | HIS8 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue HCS A 509 |
| Chain | Residue |
| A | TYR250 |
| A | LYS252 |
| A | HOH621 |
| A | HOH622 |
| A | HOH648 |
| A | HOH793 |
| A | HOH855 |
| B | GLY220 |
| B | TYR250 |
| B | ILE251 |
| B | LYS252 |
| B | HOH650 |
| B | HOH657 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue ACT A 510 |
| Chain | Residue |
| A | PHE43 |
| A | PHE44 |
| A | ASN45 |
| A | GLY48 |
| A | HOH607 |
| B | PHE43 |
| B | PHE44 |
| B | ASN45 |
| B | HOH647 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 501 |
| Chain | Residue |
| A | ILE10 |
| B | PHE176 |
| B | ASP179 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | SER79 |
| B | LYS104 |
| B | MET105 |
| B | GLU231 |
| B | GLY232 |
| B | ILE233 |
| B | GLY234 |
| B | TYR235 |
| B | HOH625 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | LEU219 |
| B | GLY221 |
| B | ASN244 |
| B | HOH620 |
| B | HOH818 |
| B | HOH824 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | ASN13 |
| B | TYR56 |
| B | HOH675 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| A | ASP174 |
| B | HIS8 |
| B | GLU320 |
| B | HOH618 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue ACT B 506 |
| Chain | Residue |
| B | LYS51 |
| B | THR78 |
| B | SER79 |
| B | ASN81 |
| B | THR82 |
| B | GLN154 |
| B | PLP507 |
| site_id | AD8 |
| Number of Residues | 18 |
| Details | binding site for residue PLP B 507 |
| Chain | Residue |
| B | GLY190 |
| B | GLY191 |
| B | THR192 |
| B | GLY232 |
| B | ILE233 |
| B | SER276 |
| B | PRO302 |
| B | ASP303 |
| B | ACT506 |
| B | HOH612 |
| B | HOH616 |
| B | HOH655 |
| B | HOH668 |
| B | LYS51 |
| B | SER79 |
| B | ASN81 |
| B | GLY188 |
| B | THR189 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | LEU15 |
| B | ALA16 |
| B | ILE18 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue ACT B 509 |
| Chain | Residue |
| A | PHE44 |
| B | THR17 |
| B | GLY19 |
| B | HIS20 |
| B | THR21 |
| B | PHE44 |
| B | ASN45 |
| B | HOH779 |
Functional Information from PROSITE/UniProt
| site_id | PS00901 |
| Number of Residues | 19 |
| Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KcEffn.PGgSVKdRiGyeM |
| Chain | Residue | Details |
| A | LYS40-MET58 | |
| B | LYS40-MET58 |
