6VEN
Yeast COMPASS in complex with a ubiquitinated nucleosome
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000786 | cellular_component | nucleosome |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0030527 | molecular_function | structural constituent of chromatin |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0000786 | cellular_component | nucleosome |
| B | 0003677 | molecular_function | DNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005694 | cellular_component | chromosome |
| B | 0006334 | biological_process | nucleosome assembly |
| B | 0030527 | molecular_function | structural constituent of chromatin |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| C | 0000786 | cellular_component | nucleosome |
| C | 0003677 | molecular_function | DNA binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005694 | cellular_component | chromosome |
| C | 0030527 | molecular_function | structural constituent of chromatin |
| C | 0046982 | molecular_function | protein heterodimerization activity |
| D | 0000786 | cellular_component | nucleosome |
| D | 0003677 | molecular_function | DNA binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005694 | cellular_component | chromosome |
| D | 0030527 | molecular_function | structural constituent of chromatin |
| D | 0046982 | molecular_function | protein heterodimerization activity |
| E | 0000786 | cellular_component | nucleosome |
| E | 0003677 | molecular_function | DNA binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005694 | cellular_component | chromosome |
| E | 0030527 | molecular_function | structural constituent of chromatin |
| E | 0046982 | molecular_function | protein heterodimerization activity |
| F | 0000786 | cellular_component | nucleosome |
| F | 0003677 | molecular_function | DNA binding |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005694 | cellular_component | chromosome |
| F | 0006334 | biological_process | nucleosome assembly |
| F | 0030527 | molecular_function | structural constituent of chromatin |
| F | 0046982 | molecular_function | protein heterodimerization activity |
| G | 0000786 | cellular_component | nucleosome |
| G | 0003677 | molecular_function | DNA binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005694 | cellular_component | chromosome |
| G | 0030527 | molecular_function | structural constituent of chromatin |
| G | 0046982 | molecular_function | protein heterodimerization activity |
| H | 0000786 | cellular_component | nucleosome |
| H | 0003677 | molecular_function | DNA binding |
| H | 0005515 | molecular_function | protein binding |
| H | 0005634 | cellular_component | nucleus |
| H | 0005694 | cellular_component | chromosome |
| H | 0030527 | molecular_function | structural constituent of chromatin |
| H | 0046982 | molecular_function | protein heterodimerization activity |
| L | 0000723 | biological_process | telomere maintenance |
| L | 0000781 | cellular_component | chromosome, telomeric region |
| L | 0005515 | molecular_function | protein binding |
| L | 0005634 | cellular_component | nucleus |
| L | 0005694 | cellular_component | chromosome |
| L | 0031509 | biological_process | subtelomeric heterochromatin formation |
| L | 0042393 | molecular_function | histone binding |
| L | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| L | 0048188 | cellular_component | Set1C/COMPASS complex |
| L | 1903341 | biological_process | regulation of meiotic DNA double-strand break formation |
| M | 0000723 | biological_process | telomere maintenance |
| M | 0000781 | cellular_component | chromosome, telomeric region |
| M | 0005515 | molecular_function | protein binding |
| M | 0005634 | cellular_component | nucleus |
| M | 0005694 | cellular_component | chromosome |
| M | 0006355 | biological_process | regulation of DNA-templated transcription |
| M | 0031509 | biological_process | subtelomeric heterochromatin formation |
| M | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| M | 0048188 | cellular_component | Set1C/COMPASS complex |
| N | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| O | 0000723 | biological_process | telomere maintenance |
| O | 0000781 | cellular_component | chromosome, telomeric region |
| O | 0000976 | molecular_function | transcription cis-regulatory region binding |
| O | 0005515 | molecular_function | protein binding |
| O | 0005634 | cellular_component | nucleus |
| O | 0005694 | cellular_component | chromosome |
| O | 0031509 | biological_process | subtelomeric heterochromatin formation |
| O | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| O | 0048188 | cellular_component | Set1C/COMPASS complex |
| P | 0000781 | cellular_component | chromosome, telomeric region |
| P | 0005515 | molecular_function | protein binding |
| P | 0005634 | cellular_component | nucleus |
| P | 0031509 | biological_process | subtelomeric heterochromatin formation |
| P | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| P | 0048188 | cellular_component | Set1C/COMPASS complex |
| Q | 0000781 | cellular_component | chromosome, telomeric region |
| Q | 0005515 | molecular_function | protein binding |
| Q | 0005634 | cellular_component | nucleus |
| Q | 0031509 | biological_process | subtelomeric heterochromatin formation |
| Q | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| Q | 0048188 | cellular_component | Set1C/COMPASS complex |
| R | 0000781 | cellular_component | chromosome, telomeric region |
| R | 0003682 | molecular_function | chromatin binding |
| R | 0005515 | molecular_function | protein binding |
| R | 0005634 | cellular_component | nucleus |
| R | 0005829 | cellular_component | cytosol |
| R | 0006355 | biological_process | regulation of DNA-templated transcription |
| R | 0008270 | molecular_function | zinc ion binding |
| R | 0031509 | biological_process | subtelomeric heterochromatin formation |
| R | 0035064 | molecular_function | methylated histone binding |
| R | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| R | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| R | 0046872 | molecular_function | metal ion binding |
| R | 0048188 | cellular_component | Set1C/COMPASS complex |
| R | 1903341 | biological_process | regulation of meiotic DNA double-strand break formation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN N 1101 |
| Chain | Residue |
| N | CYS1019 |
| N | CYS1068 |
| N | CYS1070 |
| N | CYS1075 |
| N | LYS1076 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue SAM N 1102 |
| Chain | Residue |
| N | SER992 |
| N | TYR993 |
| N | ARG1013 |
| N | ASN1016 |
| N | HIS1017 |
| N | TYR1054 |
| N | LEU1069 |
| N | LEU1079 |
| N | ILE947 |
| N | HIS948 |
| N | TRP950 |
| N | SER991 |
Functional Information from PROSITE/UniProt
| site_id | PS00046 |
| Number of Residues | 7 |
| Details | HISTONE_H2A Histone H2A signature. AGLqFPV |
| Chain | Residue | Details |
| C | ALA21-VAL27 |
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| B | GLY14-HIS18 |
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| K | LYS27-ASP52 |
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| A | LYS14-LEU20 |
| site_id | PS00357 |
| Number of Residues | 23 |
| Details | HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG |
| Chain | Residue | Details |
| D | ARG92-GLY114 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LFTSsmDeSIKIWDT |
| Chain | Residue | Details |
| L | LEU111-THR125 | |
| M | LEU87-LEU101 |
| site_id | PS00959 |
| Number of Residues | 9 |
| Details | HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI |
| Chain | Residue | Details |
| A | PRO66-ILE74 |
| site_id | PS01359 |
| Number of Residues | 45 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. Ci.Ckrpdygelm....................................VgCdg..Cddw.FHftClhipeqfkdlvfs................................FyCpyC |
| Chain | Residue | Details |
| R | CYS25-CYS69 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | ZN_FING: PHD-type => ECO:0000255|PROSITE-ProRule:PRU00146, ECO:0000269|PubMed:31253666, ECO:0007744|PDB:6J2P |
| Chain | Residue | Details |
| R | ASP22-GLY72 | |
| M | LYS266 | |
| D | LYS15 | |
| D | LYS20 | |
| H | LYS5 | |
| H | LYS12 | |
| H | LYS15 | |
| H | LYS20 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00146, ECO:0000269|PubMed:31253666, ECO:0007744|PDB:6J2P |
| Chain | Residue | Details |
| R | CYS25 | |
| R | CYS27 | |
| R | CYS39 | |
| R | CYS42 | |
| R | HIS47 | |
| R | CYS50 | |
| R | CYS66 | |
| R | CYS69 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31253666, ECO:0007744|PDB:6J2P |
| Chain | Residue | Details |
| R | CYS97 | |
| R | CYS102 | |
| R | CYS113 | |
| R | HIS117 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| R | SER87 | |
| G | LYS36 | |
| H | CYS120 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
| Chain | Residue | Details |
| K | CYS76 | |
| C | LYS75 | |
| G | LYS74 | |
| G | LYS75 | |
| F | LYS8 | |
| F | LYS16 | |
| F | LYS44 | |
| F | LYS79 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| K | LYS6 | |
| G | GLN104 | |
| F | LYS12 | |
| F | LYS20 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| C | LYS118 | |
| K | CYS76 | |
| F | LYS31 | |
| F | LYS91 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
| Chain | Residue | Details |
| K | LYS11 | |
| K | LYS48 | |
| C | LYS15 | |
| C | LYS119 | |
| G | LYS13 | |
| G | LYS15 | |
| G | LYS119 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
| Chain | Residue | Details |
| K | LYS27 | |
| B | TYR88 | |
| F | TYR51 | |
| F | TYR88 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
| Chain | Residue | Details |
| K | LYS29 | |
| E | LYS64 | |
| F | LYS59 | |
| A | LYS27 | |
| A | LYS36 | |
| A | LYS64 | |
| E | LYS18 | |
| E | LYS23 | |
| E | LYS27 | |
| E | LYS36 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
| Chain | Residue | Details |
| K | LYS33 | |
| F | LYS77 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
| Chain | Residue | Details |
| K | LYS63 | |
| F | LYS31 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805 |
| Chain | Residue | Details |
| A | LYS37 | |
| B | LYS91 | |
| F | LYS91 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| A | TYR41 | |
| E | TYR41 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228 |
| Chain | Residue | Details |
| A | LYS56 | |
| A | LYS79 | |
| E | LYS56 | |
| E | LYS79 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| A | SER57 | |
| E | SER57 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| A | THR80 | |
| A | THR107 | |
| E | THR80 | |
| E | THR107 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | SER86 | |
| E | SER86 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| A | LYS115 | |
| E | LYS115 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| A | LYS122 | |
| E | LYS122 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| A | CYS110 | |
| E | CYS110 |
