6VE1
Crystal structure of endo-beta-N-acetylglucosaminidase H at high pH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0033925 | molecular_function | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0033925 | molecular_function | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| C | 0033925 | molecular_function | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| D | 0033925 | molecular_function | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 301 |
| Chain | Residue |
| A | ASP187 |
| A | SER189 |
| A | ALA209 |
| A | HOH522 |
| B | ASP239 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | ASP190 |
| A | HOH498 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 301 |
| Chain | Residue |
| B | LEU210 |
| B | GLN214 |
| B | HOH647 |
| B | ASP190 |
| B | PHE192 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG C 301 |
| Chain | Residue |
| C | ASN22 |
| C | ALA49 |
| C | ASN66 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 302 |
| Chain | Residue |
| C | TYR32 |
| C | ASP251 |
| C | GLY252 |
| C | GLY253 |
| C | ARG273 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 301 |
| Chain | Residue |
| D | ASN173 |
| D | ASN197 |
| D | GLN204 |
| D | PRO206 |
| D | HOH449 |
Functional Information from PROSITE/UniProt
| site_id | PS01095 |
| Number of Residues | 9 |
| Details | GH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. LDGVDFDdE |
| Chain | Residue | Details |
| A | LEU128-GLU136 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01258, ECO:0000305|PubMed:10595536 |
| Chain | Residue | Details |
| A | GLU136 | |
| B | GLU136 | |
| C | GLU136 | |
| D | GLU136 |
