6VBG

Lactose permease complex with thiodigalactoside and nanobody 9043

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005351	molecular_function	carbohydrate:proton symporter activity
A	0008643	biological_process	carbohydrate transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
B	0005351	molecular_function	carbohydrate:proton symporter activity
B	0008643	biological_process	carbohydrate transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00896
Number of Residues	15
Details	LACY_1 LacY family proton/sugar symporters signature 1. GLLsDKLGLRKyLLW

Chain	Residue	Details
A	GLY64-TRP78

---

site_id	PS00897
Number of Residues	15
Details	LACY_2 LacY family proton/sugar symporters signature 2. PlIINRIGgKNALLL

Chain	Residue	Details
A	PRO280-LEU294

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:2164211

Chain	Residue	Details
A	MET1-THR7
B	ALA187-PRO220
B	ALA279-GLY288
B	LYS335-SER346
A	GLY71-LYS74
A	GLU130-PHE140
A	ALA187-PRO220
A	ALA279-GLY288
A	LYS335-SER346
B	MET1-THR7
B	GLY71-LYS74
B	GLU130-PHE140

---

site_id	SWS_FT_FI2
Number of Residues	52
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	ASN8-LEU34
B	ASN8-LEU34

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	TOPO_DOM: Periplasmic => ECO:0000269|PubMed:2164211

Chain	Residue	Details
A	HIS35-SER41
B	PHE250-THR253
B	ALA309-SER311
B	SER375-GLY377
A	TYR101-LEU104
A	ILE164-ASN166
A	PHE250-THR253
A	ALA309-SER311
A	SER375-GLY377
B	HIS35-SER41
B	TYR101-LEU104
B	ILE164-ASN166

---

site_id	SWS_FT_FI4
Number of Residues	56
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	LYS42-LEU70
B	LYS42-LEU70

---

site_id	SWS_FT_FI5
Number of Residues	50
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	TYR75-GLN100
B	TYR75-GLN100

---

site_id	SWS_FT_FI6
Number of Residues	48
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	VAL105-ILE129
B	VAL105-ILE129

---

site_id	SWS_FT_FI7
Number of Residues	44
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	GLY141-THR163
B	GLY141-THR163

---

site_id	SWS_FT_FI8
Number of Residues	38
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	GLN167-PHE186
B	GLN167-PHE186

---

site_id	SWS_FT_FI9
Number of Residues	56
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LYS221-SER249
B	LYS221-SER249

---

site_id	SWS_FT_FI10
Number of Residues	48
Details	TRANSMEM: Helical; Name=8

Chain	Residue	Details
A	GLY254-PHE278
B	GLY254-PHE278

---

site_id	SWS_FT_FI11
Number of Residues	38
Details	TRANSMEM: Helical; Name=9

Chain	Residue	Details
A	LYS289-PHE308
B	LYS289-PHE308

---

site_id	SWS_FT_FI12
Number of Residues	44
Details	TRANSMEM: Helical; Name=10

Chain	Residue	Details
A	ALA312-PHE334
B	ALA312-PHE334

---

site_id	SWS_FT_FI13
Number of Residues	54
Details	TRANSMEM: Helical; Name=11

Chain	Residue	Details
A	ALA347-GLU374
B	ALA347-GLU374

---

site_id	SWS_FT_FI14
Number of Residues	40
Details	TRANSMEM: Helical; Name=12

Chain	Residue	Details
A	PHE378-PHE398
B	PHE378-PHE398

---

site_id	SWS_FT_FI15
Number of Residues	36
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2164211

Chain	Residue	Details
A	THR399-ALA417
B	THR399-ALA417

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	SITE: Substrate binding => ECO:0000305|PubMed:12893935

Chain	Residue	Details
A	GLU126
A	ARG144
B	GLU126
B	ARG144

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	SITE: Substrate binding and proton translocation => ECO:0000305|PubMed:12893935

Chain	Residue	Details
A	GLU269
B	GLU269

---

site_id	SWS_FT_FI18
Number of Residues	6
Details	SITE: Proton translocation => ECO:0000305|PubMed:12893935

Chain	Residue	Details
A	ARG302
A	HIS322
A	GLU325
B	ARG302
B	HIS322
B	GLU325

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N-formylmethionine; partial => ECO:0000269|PubMed:10485888

Chain	Residue	Details
A	MET1
B	MET1

---