6VA8
Crystal structure of glucose-6-phosphate dehydrogenase F381L mutant in complex with catalytic NADP+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004345 | molecular_function | glucose-6-phosphate dehydrogenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005536 | molecular_function | D-glucose binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006098 | biological_process | pentose-phosphate shunt |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006695 | biological_process | cholesterol biosynthetic process |
| A | 0006739 | biological_process | NADP+ metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0010041 | biological_process | response to iron(III) ion |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| A | 0019322 | biological_process | pentose biosynthetic process |
| A | 0021762 | biological_process | substantia nigra development |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0032094 | biological_process | response to food |
| A | 0034451 | cellular_component | centriolar satellite |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043249 | biological_process | erythrocyte maturation |
| A | 0043523 | biological_process | regulation of neuron apoptotic process |
| A | 0045471 | biological_process | response to ethanol |
| A | 0046390 | biological_process | ribose phosphate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 0061052 | biological_process | negative regulation of cell growth involved in cardiac muscle cell development |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1904879 | biological_process | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| A | 2000378 | biological_process | negative regulation of reactive oxygen species metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue NAP A 601 |
| Chain | Residue |
| A | SER40 |
| A | ALA127 |
| A | GLN133 |
| A | LEU142 |
| A | PRO143 |
| A | PRO144 |
| A | GLU170 |
| A | LYS171 |
| A | PRO172 |
| A | TYR202 |
| A | TYR249 |
| A | GLY41 |
| A | PHE253 |
| A | ASP42 |
| A | LEU43 |
| A | ALA71 |
| A | ARG72 |
| A | SER73 |
| A | TYR112 |
| A | ASN126 |
Functional Information from PROSITE/UniProt
| site_id | PS00069 |
| Number of Residues | 7 |
| Details | G6P_DEHYDROGENASE Glucose-6-phosphate dehydrogenase active site. DHYLGKE |
| Chain | Residue | Details |
| A | ASP200-GLU206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P11411","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10745013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15858258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BH9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15858258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BH9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15858258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BHL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
