6V9K

CRYSTAL STRUCTURE OF THE HYBRID C-TERMINAL DOMAIN OF ENZYME I OF THE BACTERIAL PHOSPHOTRANSFERASE SYSTEM FORMED BY HYBRIDIZING THE SCAFFOLD OF THE ESCHERICHIA COLI ENZYME WITH THE ACTIVE SITE LOOPS FROM THE THERMOANAEROBACTER TENGCONGENSIS ENZYME

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0016310	biological_process	phosphorylation
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0003824	molecular_function	catalytic activity
B	0016310	biological_process	phosphorylation
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MG A 601

Chain	Residue
A	ARG358
A	GLU431
A	ASP455
A	HOH709
A	HOH710
A	HOH767
A	HOH838

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site_id	AC2
Number of Residues	7
Details	binding site for residue MG B 601

Chain	Residue
B	ASP455
B	HOH702
B	HOH725
B	HOH799
B	HOH811
B	ARG358
B	GLU431

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Functional Information from PROSITE/UniProt

site_id	PS00742
Number of Residues	19
Details	PEP_ENZYMES_2 PEP-utilizing enzymes signature 2. DfFSIGTNDLtQYTLAvdR

Chain	Residue	Details
A	ASP447-ARG465

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"12705838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17053069","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P23533","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17053069","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 920

Chain	Residue	Details
A	GLU431	metal ligand
A	ASP455	metal ligand
A	CYS502	proton shuttle (general acid/base)

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 920

Chain	Residue	Details
B	GLU431	metal ligand
B	ASP455	metal ligand
B	CYS502	proton shuttle (general acid/base)

---