6V8D

Design, Synthesis, and Mechanism of Fluorine-substituted Cyclohexene Analogues of GAMA-Aminobutyric Acid (GABA) as Selective Ornithine Aminotransferase Inactivators

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004587	molecular_function	ornithine aminotransferase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0007601	biological_process	visual perception
A	0008483	molecular_function	transaminase activity
A	0010121	biological_process	L-arginine catabolic process to proline via ornithine
A	0016740	molecular_function	transferase activity
A	0019544	biological_process	L-arginine catabolic process to L-glutamate
A	0030170	molecular_function	pyridoxal phosphate binding
A	0042802	molecular_function	identical protein binding
A	0055129	biological_process	L-proline biosynthetic process
B	0004587	molecular_function	ornithine aminotransferase activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0007601	biological_process	visual perception
B	0008483	molecular_function	transaminase activity
B	0010121	biological_process	L-arginine catabolic process to proline via ornithine
B	0016740	molecular_function	transferase activity
B	0019544	biological_process	L-arginine catabolic process to L-glutamate
B	0030170	molecular_function	pyridoxal phosphate binding
B	0042802	molecular_function	identical protein binding
B	0055129	biological_process	L-proline biosynthetic process
C	0004587	molecular_function	ornithine aminotransferase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0007601	biological_process	visual perception
C	0008483	molecular_function	transaminase activity
C	0010121	biological_process	L-arginine catabolic process to proline via ornithine
C	0016740	molecular_function	transferase activity
C	0019544	biological_process	L-arginine catabolic process to L-glutamate
C	0030170	molecular_function	pyridoxal phosphate binding
C	0042802	molecular_function	identical protein binding
C	0055129	biological_process	L-proline biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00600
Number of Residues	38
Details	AA_TRANSFER_CLASS_3 Aminotransferases class-III pyridoxal-phosphate attachment site. FIaDEIqt.GLaRtGrwlavdyenvrp....DIVllGKalsGG

Chain	Residue	Details
A	PHE260-GLY297

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P29758","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P29758","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	9
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P29758","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"3754226","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 929

Chain	Residue	Details
A	PHE177	steric role
A	ASP263	electrostatic stabiliser
A	LYS292	covalent catalysis, proton shuttle (general acid/base)

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site_id	MCSA2
Number of Residues	3
Details	M-CSA 929

Chain	Residue	Details
B	PHE177	steric role
B	ASP263	electrostatic stabiliser
B	LYS292	covalent catalysis, proton shuttle (general acid/base)

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site_id	MCSA3
Number of Residues	3
Details	M-CSA 929

Chain	Residue	Details
C	PHE177	steric role
C	ASP263	electrostatic stabiliser
C	LYS292	covalent catalysis, proton shuttle (general acid/base)

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