6V7W

Crystal structure of LasR-Aqs1 complex from Pseudomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001216	molecular_function	DNA-binding transcription activator activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0009372	biological_process	quorum sensing
B	0010468	biological_process	regulation of gene expression
B	0032993	cellular_component	protein-DNA complex
B	0043565	molecular_function	sequence-specific DNA binding
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0060310	biological_process	regulation of elastin catabolic process
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0001216	molecular_function	DNA-binding transcription activator activity
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006351	biological_process	DNA-templated transcription
E	0006355	biological_process	regulation of DNA-templated transcription
E	0009372	biological_process	quorum sensing
E	0010468	biological_process	regulation of gene expression
E	0032993	cellular_component	protein-DNA complex
E	0043565	molecular_function	sequence-specific DNA binding
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0060310	biological_process	regulation of elastin catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue OHN B 301

Chain	Residue
B	LEU36
B	PHE101
B	LEU110
B	GLY126
B	SER129
B	TYR56
B	TRP60
B	ARG61
B	TYR64
B	ASP73
B	THR75
B	VAL76
B	TRP88

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site_id	AC2
Number of Residues	11
Details	binding site for residue OHN E 301

Chain	Residue
E	LEU36
E	TRP60
E	TYR64
E	ASP73
E	THR75
E	TRP88
E	TYR93
E	LEU110
E	THR115
E	GLY126
E	SER129

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Functional Information from PROSITE/UniProt

site_id	PS00622
Number of Residues	28
Details	HTH_LUXR_1 LuxR-type HTH domain signature. GktSweISviCnCseaNVnfHmgNIrrK

Chain	Residue	Details
B	GLY191-LYS218

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	Domain: {"description":"HTH luxR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00411","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	38
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00411","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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