6V7C

Human Arginase1 Complexed with Bicyclic Inhibitor Compound 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000050	biological_process	urea cycle
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0004053	molecular_function	arginase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006525	biological_process	arginine metabolic process
A	0006527	biological_process	L-arginine catabolic process
A	0009624	biological_process	response to nematode
A	0016787	molecular_function	hydrolase activity
A	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
A	0030145	molecular_function	manganese ion binding
A	0035578	cellular_component	azurophil granule lumen
A	0035580	cellular_component	specific granule lumen
A	0042127	biological_process	regulation of cell population proliferation
A	0042130	biological_process	negative regulation of T cell proliferation
A	0042832	biological_process	defense response to protozoan
A	0045087	biological_process	innate immune response
A	0046007	biological_process	negative regulation of activated T cell proliferation
A	0046872	molecular_function	metal ion binding
A	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
A	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
A	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
B	0000050	biological_process	urea cycle
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0004053	molecular_function	arginase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006525	biological_process	arginine metabolic process
B	0006527	biological_process	L-arginine catabolic process
B	0009624	biological_process	response to nematode
B	0016787	molecular_function	hydrolase activity
B	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
B	0030145	molecular_function	manganese ion binding
B	0035578	cellular_component	azurophil granule lumen
B	0035580	cellular_component	specific granule lumen
B	0042127	biological_process	regulation of cell population proliferation
B	0042130	biological_process	negative regulation of T cell proliferation
B	0042832	biological_process	defense response to protozoan
B	0045087	biological_process	innate immune response
B	0046007	biological_process	negative regulation of activated T cell proliferation
B	0046872	molecular_function	metal ion binding
B	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
B	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
B	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
C	0000050	biological_process	urea cycle
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0004053	molecular_function	arginase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006525	biological_process	arginine metabolic process
C	0006527	biological_process	L-arginine catabolic process
C	0009624	biological_process	response to nematode
C	0016787	molecular_function	hydrolase activity
C	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
C	0030145	molecular_function	manganese ion binding
C	0035578	cellular_component	azurophil granule lumen
C	0035580	cellular_component	specific granule lumen
C	0042127	biological_process	regulation of cell population proliferation
C	0042130	biological_process	negative regulation of T cell proliferation
C	0042832	biological_process	defense response to protozoan
C	0045087	biological_process	innate immune response
C	0046007	biological_process	negative regulation of activated T cell proliferation
C	0046872	molecular_function	metal ion binding
C	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
C	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
C	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
D	0000050	biological_process	urea cycle
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0004053	molecular_function	arginase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006525	biological_process	arginine metabolic process
D	0006527	biological_process	L-arginine catabolic process
D	0009624	biological_process	response to nematode
D	0016787	molecular_function	hydrolase activity
D	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
D	0030145	molecular_function	manganese ion binding
D	0035578	cellular_component	azurophil granule lumen
D	0035580	cellular_component	specific granule lumen
D	0042127	biological_process	regulation of cell population proliferation
D	0042130	biological_process	negative regulation of T cell proliferation
D	0042832	biological_process	defense response to protozoan
D	0045087	biological_process	innate immune response
D	0046007	biological_process	negative regulation of activated T cell proliferation
D	0046872	molecular_function	metal ion binding
D	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
D	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
D	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
E	0000050	biological_process	urea cycle
E	0002250	biological_process	adaptive immune response
E	0002376	biological_process	immune system process
E	0004053	molecular_function	arginase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006525	biological_process	arginine metabolic process
E	0006527	biological_process	L-arginine catabolic process
E	0009624	biological_process	response to nematode
E	0016787	molecular_function	hydrolase activity
E	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
E	0030145	molecular_function	manganese ion binding
E	0035578	cellular_component	azurophil granule lumen
E	0035580	cellular_component	specific granule lumen
E	0042127	biological_process	regulation of cell population proliferation
E	0042130	biological_process	negative regulation of T cell proliferation
E	0042832	biological_process	defense response to protozoan
E	0045087	biological_process	innate immune response
E	0046007	biological_process	negative regulation of activated T cell proliferation
E	0046872	molecular_function	metal ion binding
E	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
E	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
E	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
F	0000050	biological_process	urea cycle
F	0002250	biological_process	adaptive immune response
F	0002376	biological_process	immune system process
F	0004053	molecular_function	arginase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006525	biological_process	arginine metabolic process
F	0006527	biological_process	L-arginine catabolic process
F	0009624	biological_process	response to nematode
F	0016787	molecular_function	hydrolase activity
F	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
F	0030145	molecular_function	manganese ion binding
F	0035578	cellular_component	azurophil granule lumen
F	0035580	cellular_component	specific granule lumen
F	0042127	biological_process	regulation of cell population proliferation
F	0042130	biological_process	negative regulation of T cell proliferation
F	0042832	biological_process	defense response to protozoan
F	0045087	biological_process	innate immune response
F	0046007	biological_process	negative regulation of activated T cell proliferation
F	0046872	molecular_function	metal ion binding
F	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
F	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
F	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MN A 401

Chain	Residue
A	HIS101
A	ASP124
A	ASP128
A	ASP232
A	MN402
A	QR1403

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MN A 402

Chain	Residue
A	ASP234
A	MN401
A	QR1403
A	ASP124
A	HIS126
A	ASP232

---

site_id	AC3
Number of Residues	22
Details	binding site for residue QR1 A 403

Chain	Residue
A	HIS101
A	ASP124
A	HIS126
A	ASP128
A	ASN130
A	SER137
A	HIS141
A	ASP181
A	ASP183
A	GLU186
A	ASP232
A	ASP234
A	THR246
A	GLU277
A	MN401
A	MN402
A	HOH502
A	HOH503
A	HOH545
A	HOH554
A	HOH586
A	HOH587

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MN B 401

Chain	Residue
B	HIS101
B	ASP124
B	ASP128
B	ASP232
B	MN402
B	QR1403

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MN B 402

Chain	Residue
B	ASP124
B	HIS126
B	ASP232
B	ASP234
B	MN401
B	QR1403

---

site_id	AC6
Number of Residues	21
Details	binding site for residue QR1 B 403

Chain	Residue
B	HIS101
B	ASP124
B	HIS126
B	ASP128
B	ASN130
B	SER137
B	HIS141
B	ASP181
B	ASP183
B	GLU186
B	ASP232
B	ASP234
B	THR246
B	GLU277
B	MN401
B	MN402
B	HOH504
B	HOH550
B	HOH557
B	HOH569
B	HOH579

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MN C 401

Chain	Residue
C	ASP124
C	HIS126
C	ASP232
C	ASP234
C	MN402
C	QR1403

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MN C 402

Chain	Residue
C	HIS101
C	ASP124
C	ASP128
C	ASP232
C	MN401
C	QR1403

---

site_id	AC9
Number of Residues	21
Details	binding site for residue QR1 C 403

Chain	Residue
C	HOH574
C	HIS101
C	ASP124
C	HIS126
C	ASP128
C	ASN130
C	SER137
C	HIS141
C	ASP181
C	ASP183
C	GLU186
C	ASP232
C	ASP234
C	THR246
C	GLU277
C	MN401
C	MN402
C	HOH505
C	HOH508
C	HOH523
C	HOH543

---

site_id	AD1
Number of Residues	6
Details	binding site for residue MN D 401

Chain	Residue
D	HIS101
D	ASP124
D	ASP128
D	ASP232
D	MN402
D	QR1403

---

site_id	AD2
Number of Residues	6
Details	binding site for residue MN D 402

Chain	Residue
D	ASP124
D	HIS126
D	ASP232
D	ASP234
D	MN401
D	QR1403

---

site_id	AD3
Number of Residues	21
Details	binding site for residue QR1 D 403

Chain	Residue
D	HIS101
D	ASP124
D	HIS126
D	ASP128
D	ASN130
D	SER137
D	HIS141
D	GLY142
D	ASP181
D	ASP183
D	GLU186
D	ASP232
D	ASP234
D	THR246
D	GLU277
D	MN401
D	MN402
D	HOH503
D	HOH507
D	HOH528
D	HOH557

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MN E 401

Chain	Residue
E	HIS101
E	ASP124
E	ASP128
E	ASP232
E	MN402
E	QR1403

---

site_id	AD5
Number of Residues	6
Details	binding site for residue MN E 402

Chain	Residue
E	ASP124
E	HIS126
E	ASP232
E	ASP234
E	MN401
E	QR1403

---

site_id	AD6
Number of Residues	21
Details	binding site for residue QR1 E 403

Chain	Residue
E	HIS101
E	ASP124
E	HIS126
E	ASP128
E	ASN130
E	SER137
E	HIS141
E	ASP181
E	ASP183
E	GLU186
E	ASP232
E	ASP234
E	THR246
E	GLU277
E	MN401
E	MN402
E	HOH501
E	HOH507
E	HOH544
E	HOH550
E	HOH566

---

site_id	AD7
Number of Residues	6
Details	binding site for residue MN F 401

Chain	Residue
F	ASP124
F	HIS126
F	ASP232
F	ASP234
F	MN402
F	QR1403

---

site_id	AD8
Number of Residues	6
Details	binding site for residue MN F 402

Chain	Residue
F	HIS101
F	ASP124
F	ASP128
F	ASP232
F	MN401
F	QR1403

---

site_id	AD9
Number of Residues	21
Details	binding site for residue QR1 F 403

Chain	Residue
F	HIS101
F	ASP124
F	HIS126
F	ASP128
F	ASN130
F	SER137
F	HIS141
F	GLY142
F	ASP181
F	ASP183
F	GLU186
F	ASP232
F	ASP234
F	THR246
F	GLU277
F	MN401
F	MN402
F	HOH502
F	HOH503
F	HOH525
F	HOH556

---

Functional Information from PROSITE/UniProt

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDVDgldPsftPAtgtpvvgG

Chain	Residue	Details
A	SER230-GLY251

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16141327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17469833","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17562323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18802628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21728378","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WVA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GMZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LP4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MJL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SKK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GSZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PDB","id":"3GMZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P53608","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P78540","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q61176","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q61176","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---