6V5B
Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - Active state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004525 | molecular_function | ribonuclease III activity |
| A | 0006364 | biological_process | rRNA processing |
| A | 0006396 | biological_process | RNA processing |
| A | 0031054 | biological_process | pre-miRNA processing |
| B | 0003723 | molecular_function | RNA binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0031053 | biological_process | primary miRNA processing |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0070877 | cellular_component | microprocessor complex |
| C | 0003723 | molecular_function | RNA binding |
| C | 0020037 | molecular_function | heme binding |
| C | 0031053 | biological_process | primary miRNA processing |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0070877 | cellular_component | microprocessor complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1401 |
| Chain | Residue |
| A | CYS561 |
| A | HIS609 |
| A | CYS676 |
| A | HIS680 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 1402 |
| Chain | Residue |
| A | SER539 |
| A | ALA540 |
| A | LYS541 |
| A | ALA542 |
| A | ARG543 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 1403 |
| Chain | Residue |
| A | ASP1151 |
| A | ASN1184 |
| A | GLN1187 |
| A | ASP1219 |
| A | GLU1222 |
| D | U21 |
Functional Information from PROSITE/UniProt
| site_id | PS00517 |
| Number of Residues | 9 |
| Details | RNASE_3_1 Ribonuclease III family signature. ERLEFLGDA |
| Chain | Residue | Details |
| A | GLU966-ALA974 | |
| A | GLN1144-SER1152 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 180 |
| Details | Domain: {"description":"RNase III 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 126 |
| Details | Domain: {"description":"RNase III 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 74 |
| Details | Domain: {"description":"DRBM"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26748718","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O67082","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O67082","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"15574589","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 134 |
| Details | Domain: {"description":"DRBM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00266","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by ATM","evidences":[{"source":"PubMed","id":"34188037","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
