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6V4U

Cryo-EM structure of SMCR8-C9orf72-WDR41 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000932cellular_componentP-body
A0001933biological_processnegative regulation of protein phosphorylation
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005776cellular_componentautophagosome
A0005829cellular_componentcytosol
A0006897biological_processendocytosis
A0006914biological_processautophagy
A0010494cellular_componentcytoplasmic stress granule
A0010506biological_processregulation of autophagy
A0016020cellular_componentmembrane
A0016239biological_processpositive regulation of macroautophagy
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0031267molecular_functionsmall GTPase binding
A0031965cellular_componentnuclear membrane
A0032045cellular_componentguanyl-nucleotide exchange factor complex
A0032880biological_processregulation of protein localization
A0034063biological_processstress granule assembly
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043204cellular_componentperikaryon
A0043231cellular_componentintracellular membrane-bounded organelle
A0044295cellular_componentaxonal growth cone
A0044304cellular_componentmain axon
A0045202cellular_componentsynapse
A0048675biological_processaxon extension
A0090543cellular_componentFlemming body
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A0098693biological_processregulation of synaptic vesicle cycle
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099523cellular_componentpresynaptic cytosol
A0110053biological_processregulation of actin filament organization
A1902774biological_processlate endosome to lysosome transport
A1903432biological_processregulation of TORC1 signaling
A1990316cellular_componentAtg1/ULK1 kinase complex
A2000785biological_processregulation of autophagosome assembly
B0000785cellular_componentchromatin
B0004860molecular_functionprotein kinase inhibitor activity
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005096molecular_functionGTPase activator activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0006914biological_processautophagy
B0010506biological_processregulation of autophagy
B0010629biological_processnegative regulation of gene expression
B0016242biological_processnegative regulation of macroautophagy
B0019901molecular_functionprotein kinase binding
B0032008biological_processpositive regulation of TOR signaling
B0032045cellular_componentguanyl-nucleotide exchange factor complex
B0042995cellular_componentcell projection
B0045202cellular_componentsynapse
B0045920biological_processnegative regulation of exocytosis
B0050777biological_processnegative regulation of immune response
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B1901098biological_processpositive regulation of autophagosome maturation
B1902902biological_processnegative regulation of autophagosome assembly
B1903432biological_processregulation of TORC1 signaling
B1990316cellular_componentAtg1/ULK1 kinase complex
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005096molecular_functionGTPase activator activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0006914biological_processautophagy
C0010506biological_processregulation of autophagy
C0032045cellular_componentguanyl-nucleotide exchange factor complex
C0045920biological_processnegative regulation of exocytosis
C0050777biological_processnegative regulation of immune response
C1990316cellular_componentAtg1/ULK1 kinase complex
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. ILTAsaDrTVIVWDG
ChainResidueDetails
CILE106-GLY120
CLEU337-LEU351

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:27103069
ChainResidueDetails
BSER402

site_idSWS_FT_FI2
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER417
BSER489
BSER790

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
BSER468

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:21406692
ChainResidueDetails
BSER471

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER492

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER498

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by TBK1 => ECO:0000269|PubMed:27103069
ChainResidueDetails
BTHR796

224201

PDB entries from 2024-08-28

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