6V38

Cryo-EM structure of Ca2+-bound hsSlo1 channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue MG A 1101

Chain	Residue
A	GLU399

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 1102

Chain	Residue
A	ASP367
A	ARG514
A	SER533
A	GLU535
A	SER600

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 1103

Chain	Residue
A	ASP897
D	ASN449
A	GLN889
A	ASP892
A	ASP895

---

site_id	AC4
Number of Residues	6
Details	binding site for residue POV A 1104

Chain	Residue
A	GLY310
A	MET314
A	SER317
A	TYR318
B	ILE323
B	POV1101

---

site_id	AC5
Number of Residues	3
Details	binding site for residue POV A 1105

Chain	Residue
A	ARG20
A	TRP22
A	PHE266

---

site_id	AC6
Number of Residues	1
Details	binding site for residue POV A 1107

Chain	Residue
A	PHE148

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CLR A 1109

Chain	Residue
A	TRP263
B	POV1102
B	POV1103

---

site_id	AC8
Number of Residues	1
Details	binding site for residue CLR A 1110

Chain	Residue
A	TRP23

---

site_id	AC9
Number of Residues	2
Details	binding site for residue CLR A 1111

Chain	Residue
A	VAL97
A	TRP100

---

site_id	AD1
Number of Residues	4
Details	binding site for residue POV A 1112

Chain	Residue
A	ASN328
D	THR245
D	PHE252
D	POV1106

---

site_id	AD2
Number of Residues	6
Details	binding site for residue POV A 1113

Chain	Residue
A	THR273
A	TRP275
A	GLU276
D	GLU264
D	THR298
D	CLR1111

---

site_id	AD3
Number of Residues	1
Details	binding site for residue POV A 1114

Chain	Residue
D	CLR1111

---

site_id	AD4
Number of Residues	4
Details	binding site for residue POV B 1101

Chain	Residue
A	THR245
A	PHE252
A	POV1104
B	ASN328

---

site_id	AD5
Number of Residues	6
Details	binding site for residue POV B 1102

Chain	Residue
A	GLU264
A	THR298
A	CLR1109
B	THR273
B	TRP275
B	GLU276

---

site_id	AD6
Number of Residues	1
Details	binding site for residue POV B 1103

Chain	Residue
A	CLR1109

---

site_id	AD7
Number of Residues	1
Details	binding site for residue MG B 1104

Chain	Residue
B	GLU399

---

site_id	AD8
Number of Residues	5
Details	binding site for residue CA B 1105

Chain	Residue
B	ASP367
B	ARG514
B	SER533
B	GLU535
B	SER600

---

site_id	AD9
Number of Residues	5
Details	binding site for residue CA B 1106

Chain	Residue
A	ASN449
B	GLN889
B	ASP892
B	ASP895
B	ASP897

---

site_id	AE1
Number of Residues	4
Details	binding site for residue POV B 1107

Chain	Residue
B	THR245
B	PHE252
B	POV1108
C	ASN328

---

site_id	AE2
Number of Residues	6
Details	binding site for residue POV B 1108

Chain	Residue
B	GLY310
B	MET314
B	SER317
B	TYR318
B	POV1107
C	ILE323

---

site_id	AE3
Number of Residues	3
Details	binding site for residue POV B 1109

Chain	Residue
B	ARG20
B	TRP22
B	PHE266

---

site_id	AE4
Number of Residues	1
Details	binding site for residue POV B 1111

Chain	Residue
B	PHE148

---

site_id	AE5
Number of Residues	4
Details	binding site for residue POV B 1113

Chain	Residue
B	GLU264
B	THR298
B	CLR1114
C	TRP275

---

site_id	AE6
Number of Residues	3
Details	binding site for residue CLR B 1114

Chain	Residue
B	TRP263
B	POV1113
C	POV1101

---

site_id	AE7
Number of Residues	1
Details	binding site for residue CLR B 1115

Chain	Residue
B	TRP23

---

site_id	AE8
Number of Residues	2
Details	binding site for residue CLR B 1116

Chain	Residue
B	VAL97
B	TRP100

---

site_id	AE9
Number of Residues	1
Details	binding site for residue POV C 1101

Chain	Residue
B	CLR1114

---

site_id	AF1
Number of Residues	1
Details	binding site for residue MG C 1102

Chain	Residue
C	GLU399

---

site_id	AF2
Number of Residues	5
Details	binding site for residue CA C 1103

Chain	Residue
C	ASP367
C	ARG514
C	SER533
C	GLU535
C	SER600

---

site_id	AF3
Number of Residues	5
Details	binding site for residue CA C 1104

Chain	Residue
B	ASN449
C	GLN889
C	ASP892
C	ASP895
C	ASP897

---

site_id	AF4
Number of Residues	6
Details	binding site for residue POV C 1105

Chain	Residue
C	TYR318
D	ILE323
D	POV1101
C	GLY310
C	MET314
C	SER317

---

site_id	AF5
Number of Residues	3
Details	binding site for residue POV C 1106

Chain	Residue
C	ARG20
C	TRP22
C	PHE266

---

site_id	AF6
Number of Residues	1
Details	binding site for residue POV C 1108

Chain	Residue
C	PHE148

---

site_id	AF7
Number of Residues	5
Details	binding site for residue POV C 1110

Chain	Residue
C	GLU264
C	THR298
C	CLR1111
D	THR273
D	TRP275

---

site_id	AF8
Number of Residues	3
Details	binding site for residue CLR C 1111

Chain	Residue
C	TRP263
C	POV1110
D	POV1102

---

site_id	AF9
Number of Residues	1
Details	binding site for residue CLR C 1112

Chain	Residue
C	TRP23

---

site_id	AG1
Number of Residues	2
Details	binding site for residue CLR C 1113

Chain	Residue
C	VAL97
C	TRP100

---

site_id	AG2
Number of Residues	4
Details	binding site for residue POV D 1101

Chain	Residue
C	THR245
C	PHE252
C	POV1105
D	ASN328

---

site_id	AG3
Number of Residues	1
Details	binding site for residue POV D 1102

Chain	Residue
C	CLR1111

---

site_id	AG4
Number of Residues	1
Details	binding site for residue MG D 1103

Chain	Residue
D	GLU399

---

site_id	AG5
Number of Residues	5
Details	binding site for residue CA D 1104

Chain	Residue
D	ASP367
D	ARG514
D	SER533
D	GLU535
D	SER600

---

site_id	AG6
Number of Residues	5
Details	binding site for residue CA D 1105

Chain	Residue
C	ASN449
D	GLN889
D	ASP892
D	ASP895
D	ASP897

---

site_id	AG7
Number of Residues	6
Details	binding site for residue POV D 1106

Chain	Residue
A	ILE323
A	POV1112
D	GLY310
D	MET314
D	SER317
D	TYR318

---

site_id	AG8
Number of Residues	3
Details	binding site for residue POV D 1107

Chain	Residue
D	ARG20
D	TRP22
D	PHE266

---

site_id	AG9
Number of Residues	1
Details	binding site for residue POV D 1109

Chain	Residue
D	PHE148

---

site_id	AH1
Number of Residues	3
Details	binding site for residue CLR D 1111

Chain	Residue
A	POV1113
A	POV1114
D	TRP263

---

site_id	AH2
Number of Residues	1
Details	binding site for residue CLR D 1112

Chain	Residue
D	TRP23

---

site_id	AH3
Number of Residues	2
Details	binding site for residue CLR D 1113

Chain	Residue
D	VAL97
D	TRP100

---

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. VITNPPY

Chain	Residue	Details
A	VAL1033-TYR1039

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S0","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	152
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	68
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	88
Details	Intramembrane: {"description":"Pore-forming; Name=P region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	568
Details	Domain: {"description":"RCK N-terminal 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00543","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	80
Details	Region: {"description":"Segment S7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	80
Details	Region: {"description":"Segment S9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	80
Details	Region: {"description":"Segment S10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	12
Details	Motif: {"description":"Selectivity for potassium"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	88
Details	Motif: {"description":"Calcium bowl","evidences":[{"source":"UniProtKB","id":"B7ZC96","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"B7ZC96","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---