Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6V38

Cryo-EM structure of Ca2+-bound hsSlo1 channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue MG A 1101

Chain	Residue
A	GLU399

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 1102

Chain	Residue
A	ASP367
A	ARG514
A	SER533
A	GLU535
A	SER600

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 1103

Chain	Residue
A	ASP897
D	ASN449
A	GLN889
A	ASP892
A	ASP895

site_id	AC4
Number of Residues	6
Details	binding site for residue POV A 1104

Chain	Residue
A	GLY310
A	MET314
A	SER317
A	TYR318
B	ILE323
B	POV1101

site_id	AC5
Number of Residues	3
Details	binding site for residue POV A 1105

Chain	Residue
A	ARG20
A	TRP22
A	PHE266

site_id	AC6
Number of Residues	1
Details	binding site for residue POV A 1107

Chain	Residue
A	PHE148

site_id	AC7
Number of Residues	3
Details	binding site for residue CLR A 1109

Chain	Residue
A	TRP263
B	POV1102
B	POV1103

site_id	AC8
Number of Residues	1
Details	binding site for residue CLR A 1110

Chain	Residue
A	TRP23

site_id	AC9
Number of Residues	2
Details	binding site for residue CLR A 1111

Chain	Residue
A	VAL97
A	TRP100

site_id	AD1
Number of Residues	4
Details	binding site for residue POV A 1112

Chain	Residue
A	ASN328
D	THR245
D	PHE252
D	POV1106

site_id	AD2
Number of Residues	6
Details	binding site for residue POV A 1113

Chain	Residue
A	THR273
A	TRP275
A	GLU276
D	GLU264
D	THR298
D	CLR1111

site_id	AD3
Number of Residues	1
Details	binding site for residue POV A 1114

Chain	Residue
D	CLR1111

site_id	AD4
Number of Residues	4
Details	binding site for residue POV B 1101

Chain	Residue
A	THR245
A	PHE252
A	POV1104
B	ASN328

site_id	AD5
Number of Residues	6
Details	binding site for residue POV B 1102

Chain	Residue
A	GLU264
A	THR298
A	CLR1109
B	THR273
B	TRP275
B	GLU276

site_id	AD6
Number of Residues	1
Details	binding site for residue POV B 1103

Chain	Residue
A	CLR1109

site_id	AD7
Number of Residues	1
Details	binding site for residue MG B 1104

Chain	Residue
B	GLU399

site_id	AD8
Number of Residues	5
Details	binding site for residue CA B 1105

Chain	Residue
B	ASP367
B	ARG514
B	SER533
B	GLU535
B	SER600

site_id	AD9
Number of Residues	5
Details	binding site for residue CA B 1106

Chain	Residue
A	ASN449
B	GLN889
B	ASP892
B	ASP895
B	ASP897

site_id	AE1
Number of Residues	4
Details	binding site for residue POV B 1107

Chain	Residue
B	THR245
B	PHE252
B	POV1108
C	ASN328

site_id	AE2
Number of Residues	6
Details	binding site for residue POV B 1108

Chain	Residue
B	GLY310
B	MET314
B	SER317
B	TYR318
B	POV1107
C	ILE323

site_id	AE3
Number of Residues	3
Details	binding site for residue POV B 1109

Chain	Residue
B	ARG20
B	TRP22
B	PHE266

site_id	AE4
Number of Residues	1
Details	binding site for residue POV B 1111

Chain	Residue
B	PHE148

site_id	AE5
Number of Residues	4
Details	binding site for residue POV B 1113

Chain	Residue
B	GLU264
B	THR298
B	CLR1114
C	TRP275

site_id	AE6
Number of Residues	3
Details	binding site for residue CLR B 1114

Chain	Residue
B	TRP263
B	POV1113
C	POV1101

site_id	AE7
Number of Residues	1
Details	binding site for residue CLR B 1115

Chain	Residue
B	TRP23

site_id	AE8
Number of Residues	2
Details	binding site for residue CLR B 1116

Chain	Residue
B	VAL97
B	TRP100

site_id	AE9
Number of Residues	1
Details	binding site for residue POV C 1101

Chain	Residue
B	CLR1114

site_id	AF1
Number of Residues	1
Details	binding site for residue MG C 1102

Chain	Residue
C	GLU399

site_id	AF2
Number of Residues	5
Details	binding site for residue CA C 1103

Chain	Residue
C	ASP367
C	ARG514
C	SER533
C	GLU535
C	SER600

site_id	AF3
Number of Residues	5
Details	binding site for residue CA C 1104

Chain	Residue
B	ASN449
C	GLN889
C	ASP892
C	ASP895
C	ASP897

site_id	AF4
Number of Residues	6
Details	binding site for residue POV C 1105

Chain	Residue
C	TYR318
D	ILE323
D	POV1101
C	GLY310
C	MET314
C	SER317

site_id	AF5
Number of Residues	3
Details	binding site for residue POV C 1106

Chain	Residue
C	ARG20
C	TRP22
C	PHE266

site_id	AF6
Number of Residues	1
Details	binding site for residue POV C 1108

Chain	Residue
C	PHE148

site_id	AF7
Number of Residues	5
Details	binding site for residue POV C 1110

Chain	Residue
C	GLU264
C	THR298
C	CLR1111
D	THR273
D	TRP275

site_id	AF8
Number of Residues	3
Details	binding site for residue CLR C 1111

Chain	Residue
C	TRP263
C	POV1110
D	POV1102

site_id	AF9
Number of Residues	1
Details	binding site for residue CLR C 1112

Chain	Residue
C	TRP23

site_id	AG1
Number of Residues	2
Details	binding site for residue CLR C 1113

Chain	Residue
C	VAL97
C	TRP100

site_id	AG2
Number of Residues	4
Details	binding site for residue POV D 1101

Chain	Residue
C	THR245
C	PHE252
C	POV1105
D	ASN328

site_id	AG3
Number of Residues	1
Details	binding site for residue POV D 1102

Chain	Residue
C	CLR1111

site_id	AG4
Number of Residues	1
Details	binding site for residue MG D 1103

Chain	Residue
D	GLU399

site_id	AG5
Number of Residues	5
Details	binding site for residue CA D 1104

Chain	Residue
D	ASP367
D	ARG514
D	SER533
D	GLU535
D	SER600

site_id	AG6
Number of Residues	5
Details	binding site for residue CA D 1105

Chain	Residue
C	ASN449
D	GLN889
D	ASP892
D	ASP895
D	ASP897

site_id	AG7
Number of Residues	6
Details	binding site for residue POV D 1106

Chain	Residue
A	ILE323
A	POV1112
D	GLY310
D	MET314
D	SER317
D	TYR318

site_id	AG8
Number of Residues	3
Details	binding site for residue POV D 1107

Chain	Residue
D	ARG20
D	TRP22
D	PHE266

site_id	AG9
Number of Residues	1
Details	binding site for residue POV D 1109

Chain	Residue
D	PHE148

site_id	AH1
Number of Residues	3
Details	binding site for residue CLR D 1111

Chain	Residue
A	POV1113
A	POV1114
D	TRP263

site_id	AH2
Number of Residues	1
Details	binding site for residue CLR D 1112

Chain	Residue
D	TRP23

site_id	AH3
Number of Residues	2
Details	binding site for residue CLR D 1113

Chain	Residue
D	VAL97
D	TRP100

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. VITNPPY

Chain	Residue	Details
A	VAL1033-TYR1039

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S0 => ECO:0000255

Chain	Residue	Details
A	TRP22-LEU42
B	TRP22-LEU42
C	TRP22-LEU42
D	TRP22-LEU42

site_id	SWS_FT_FI2
Number of Residues	348
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP43-ARG113
D	TRP43-ARG113
D	ALA171-LYS174
D	LEU221-LEU235
A	ALA171-LYS174
A	LEU221-LEU235
B	TRP43-ARG113
B	ALA171-LYS174
B	LEU221-LEU235
C	TRP43-ARG113
C	ALA171-LYS174
C	LEU221-LEU235

site_id	SWS_FT_FI3
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S1 => ECO:0000255

Chain	Residue	Details
A	VAL114-SER134
B	VAL114-SER134
C	VAL114-SER134
D	VAL114-SER134

site_id	SWS_FT_FI4
Number of Residues	152
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	SER135-THR149
C	SER196-LEU199
C	GLU257-GLN270
C	TYR294-LEU302
D	SER135-THR149
D	SER196-LEU199
D	GLU257-GLN270
D	TYR294-LEU302
A	SER196-LEU199
A	GLU257-GLN270
A	TYR294-LEU302
B	SER135-THR149
B	SER196-LEU199
B	GLU257-GLN270
B	TYR294-LEU302
C	SER135-THR149

site_id	SWS_FT_FI5
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S2 => ECO:0000255

Chain	Residue	Details
A	LEU150-ALA170
B	LEU150-ALA170
C	LEU150-ALA170
D	LEU150-ALA170

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S3 => ECO:0000255

Chain	Residue	Details
A	LEU175-VAL195
B	LEU175-VAL195
C	LEU175-VAL195
D	LEU175-VAL195

site_id	SWS_FT_FI7
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S4 => ECO:0000255

Chain	Residue	Details
A	ASN200-ILE220
B	ASN200-ILE220
C	ASN200-ILE220
D	ASN200-ILE220

site_id	SWS_FT_FI8
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S5 => ECO:0000255

Chain	Residue	Details
A	VAL236-VAL256
B	VAL236-VAL256
C	VAL236-VAL256
D	VAL236-VAL256

site_id	SWS_FT_FI9
Number of Residues	88
Details	INTRAMEM: Pore-forming; Name=P region => ECO:0000255

Chain	Residue	Details
A	ALA271-VAL293
B	ALA271-VAL293
C	ALA271-VAL293
D	ALA271-VAL293

site_id	SWS_FT_FI10
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S6 => ECO:0000255

Chain	Residue	Details
A	PHE303-ILE323
B	PHE303-ILE323
C	PHE303-ILE323
D	PHE303-ILE323

site_id	SWS_FT_FI11
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	GLU374
D	GLU374
D	GLN397
D	GLU399
A	GLN397
A	GLU399
B	GLU374
B	GLN397
B	GLU399
C	GLU374
C	GLN397
C	GLU399

site_id	SWS_FT_FI12
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:B7ZC96

Chain	Residue	Details
A	PRO947
C	GLU950
C	ILE953
C	GLU955
D	PRO947
D	GLU950
D	ILE953
D	GLU955
A	GLU950
A	ILE953
A	GLU955
B	PRO947
B	GLU950
B	ILE953
B	GLU955
C	PRO947

site_id	SWS_FT_FI13
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q08460

Chain	Residue	Details
A	LYS698
A	LEU905
B	LYS698
B	LEU905
C	LYS698
C	LEU905
D	LYS698
D	LEU905

site_id	SWS_FT_FI14
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q08460

Chain	Residue	Details
A	ILE700
B	VAL917
C	ILE700
C	THR713
C	GLY717
C	THR913
C	VAL917
D	ILE700
D	THR713
D	GLY717
D	THR913
A	THR713
D	VAL917
A	GLY717
A	THR913
A	VAL917
B	ILE700
B	THR713
B	GLY717
B	THR913

site_id	SWS_FT_FI15
Number of Residues	12
Details	LIPID: S-palmitoyl cysteine => ECO:0000269\|PubMed:20693285, ECO:0000269\|PubMed:22399288

Chain	Residue	Details
A	CYS53
D	CYS53
D	CYS54
D	CYS56
A	CYS54
A	CYS56
B	CYS53
B	CYS54
B	CYS56
C	CYS53
C	CYS54
C	CYS56

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)