6V37
K2P2.1(TREK-1)I110D:RuR:ML335 bound channel structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue R2R A 401 |
| Chain | Residue |
| A | ASP110 |
| A | GLY146 |
| B | ALA38 |
| B | ASP110 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CD A 402 |
| Chain | Residue |
| A | GLU309 |
| A | HIS313 |
| B | GLU309 |
| B | CD902 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue D12 A 404 |
| Chain | Residue |
| A | ALA300 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue Q6F A 406 |
| Chain | Residue |
| A | HIS126 |
| A | SER131 |
| A | PHE134 |
| A | ILE148 |
| A | ALA259 |
| A | GLY260 |
| A | GLY261 |
| A | VAL274 |
| A | TRP275 |
| A | ILE278 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue K A 407 |
| Chain | Residue |
| A | ILE143 |
| A | GLY144 |
| A | ILE252 |
| A | GLY253 |
| A | K408 |
| A | K410 |
| B | ILE143 |
| B | GLY144 |
| B | ILE252 |
| B | GLY253 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue K A 408 |
| Chain | Residue |
| A | THR142 |
| A | ILE143 |
| A | THR251 |
| A | ILE252 |
| A | K407 |
| B | THR142 |
| B | ILE143 |
| B | THR251 |
| B | ILE252 |
| B | K905 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue K A 409 |
| Chain | Residue |
| A | HOH501 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue K A 410 |
| Chain | Residue |
| A | GLY144 |
| A | PHE145 |
| A | GLY253 |
| A | PHE254 |
| A | K407 |
| B | GLY144 |
| B | PHE145 |
| B | GLY253 |
| B | PHE254 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue HEX B 901 |
| Chain | Residue |
| B | CYS219 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue CD B 902 |
| Chain | Residue |
| A | GLU309 |
| A | HIS313 |
| A | CD402 |
| B | GLU309 |
| B | HIS313 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue D12 B 903 |
| Chain | Residue |
| B | LEU56 |
| B | ILE60 |
| site_id | AD3 |
| Number of Residues | 13 |
| Details | binding site for residue Q6F B 904 |
| Chain | Residue |
| B | HIS126 |
| B | SER131 |
| B | PHE134 |
| B | GLY137 |
| B | THR138 |
| B | ILE148 |
| B | ALA259 |
| B | GLY260 |
| B | GLY261 |
| B | LYS271 |
| B | VAL274 |
| B | TRP275 |
| B | ILE278 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue K B 905 |
| Chain | Residue |
| A | THR142 |
| A | THR251 |
| A | K408 |
| B | THR142 |
| B | THR251 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | Intramembrane: {"description":"Pore-forming; Name=Pore-forming 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Intramembrane: {"description":"Pore-forming; Name=Pore-forming 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Region: {"description":"Selectivity filter 1","evidences":[{"source":"UniProtKB","id":"Q920B6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Region: {"description":"Selectivity filter 2","evidences":[{"source":"UniProtKB","id":"Q920B6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 52 |
| Details | Region: {"description":"Interaction with AKAP5","evidences":[{"source":"PubMed","id":"17110924","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28693035","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33127683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6W7B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6W83","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33127683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6W83","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28693035","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6W7B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6W83","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Site: {"description":"pH sensor","evidences":[{"source":"PubMed","id":"19667202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27035963","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
