6V08
Crystal structure of human recombinant Beta-2 glycoprotein I (hrB2GPI)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001937 | biological_process | negative regulation of endothelial cell proliferation |
| A | 0005515 | molecular_function | protein binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0007597 | biological_process | blood coagulation, intrinsic pathway |
| A | 0008201 | molecular_function | heparin binding |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009986 | cellular_component | cell surface |
| A | 0010596 | biological_process | negative regulation of endothelial cell migration |
| A | 0016525 | biological_process | negative regulation of angiogenesis |
| A | 0030193 | biological_process | regulation of blood coagulation |
| A | 0030194 | biological_process | positive regulation of blood coagulation |
| A | 0030195 | biological_process | negative regulation of blood coagulation |
| A | 0031089 | cellular_component | platelet dense granule lumen |
| A | 0031639 | biological_process | plasminogen activation |
| A | 0033033 | biological_process | negative regulation of myeloid cell apoptotic process |
| A | 0034197 | biological_process | triglyceride transport |
| A | 0034361 | cellular_component | very-low-density lipoprotein particle |
| A | 0034364 | cellular_component | high-density lipoprotein particle |
| A | 0034371 | biological_process | chylomicron remodeling |
| A | 0034372 | biological_process | very-low-density lipoprotein particle remodeling |
| A | 0034392 | biological_process | negative regulation of smooth muscle cell apoptotic process |
| A | 0035473 | molecular_function | lipase binding |
| A | 0042627 | cellular_component | chylomicron |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0051917 | biological_process | regulation of fibrinolysis |
| A | 0051918 | biological_process | negative regulation of fibrinolysis |
| A | 0060230 | molecular_function | lipoprotein lipase activator activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0090208 | biological_process | positive regulation of triglyceride metabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | Domain: {"description":"Sushi 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00302","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 57 |
| Details | Domain: {"description":"Sushi 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00302","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 62 |
| Details | Domain: {"description":"Sushi 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00302","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 59 |
| Details | Domain: {"description":"Sushi 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00302","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"UniProtKB","id":"P17690","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) threonine"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6587378","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6587378","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6587378","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
