Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6V00

structure of human KCNQ1-KCNE3-CaM complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0000922	cellular_component	spindle pole
B	0002027	biological_process	regulation of heart rate
B	0005509	molecular_function	calcium ion binding
B	0005513	biological_process	detection of calcium ion
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005876	cellular_component	spindle microtubule
B	0005886	cellular_component	plasma membrane
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
B	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
B	0010856	molecular_function	adenylate cyclase activator activity
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0016240	biological_process	autophagosome membrane docking
B	0019855	molecular_function	calcium channel inhibitor activity
B	0019901	molecular_function	protein kinase binding
B	0021762	biological_process	substantia nigra development
B	0030017	cellular_component	sarcomere
B	0031432	molecular_function	titin binding
B	0031514	cellular_component	motile cilium
B	0031954	biological_process	positive regulation of protein autophosphorylation
B	0031982	cellular_component	vesicle
B	0032465	biological_process	regulation of cytokinesis
B	0032991	cellular_component	protein-containing complex
B	0034704	cellular_component	calcium channel complex
B	0035458	biological_process	cellular response to interferon-beta
B	0043209	cellular_component	myelin sheath
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0044305	cellular_component	calyx of Held
B	0044325	molecular_function	transmembrane transporter binding
B	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050848	biological_process	regulation of calcium-mediated signaling
B	0051592	biological_process	response to calcium ion
B	0055117	biological_process	regulation of cardiac muscle contraction
B	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
B	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
B	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
B	0071346	biological_process	cellular response to type II interferon
B	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
B	0072542	molecular_function	protein phosphatase activator activity
B	0097225	cellular_component	sperm midpiece
B	0097720	biological_process	calcineurin-mediated signaling
B	0098901	biological_process	regulation of cardiac muscle cell action potential
B	0099523	cellular_component	presynaptic cytosol
B	0140056	biological_process	organelle localization by membrane tethering
B	0140238	biological_process	presynaptic endocytosis
B	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
B	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
B	1902494	cellular_component	catalytic complex
B	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
B	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005251	molecular_function	delayed rectifier potassium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006814	biological_process	sodium ion transport
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0008218	biological_process	bioluminescence
C	0015459	molecular_function	potassium channel regulator activity
C	0016020	cellular_component	membrane
C	0030425	cellular_component	dendrite
C	0030644	biological_process	intracellular chloride ion homeostasis
C	0031982	cellular_component	vesicle
C	0032809	cellular_component	neuronal cell body membrane
C	0042995	cellular_component	cell projection
C	0043204	cellular_component	perikaryon
C	0044325	molecular_function	transmembrane transporter binding
C	0045121	cellular_component	membrane raft
C	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
C	0071805	biological_process	potassium ion transmembrane transport
C	0086005	biological_process	ventricular cardiac muscle cell action potential
C	0086011	biological_process	membrane repolarization during action potential
C	0086091	biological_process	regulation of heart rate by cardiac conduction
C	0097623	biological_process	potassium ion export across plasma membrane
C	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
C	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
C	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
C	1903817	biological_process	negative regulation of voltage-gated potassium channel activity
C	1905025	biological_process	negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
C	1990794	cellular_component	basolateral part of cell
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000922	cellular_component	spindle pole
E	0002027	biological_process	regulation of heart rate
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005876	cellular_component	spindle microtubule
E	0005886	cellular_component	plasma membrane
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
E	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016240	biological_process	autophagosome membrane docking
E	0019855	molecular_function	calcium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0021762	biological_process	substantia nigra development
E	0030017	cellular_component	sarcomere
E	0031432	molecular_function	titin binding
E	0031514	cellular_component	motile cilium
E	0031954	biological_process	positive regulation of protein autophosphorylation
E	0031982	cellular_component	vesicle
E	0032465	biological_process	regulation of cytokinesis
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0035458	biological_process	cellular response to interferon-beta
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0044305	cellular_component	calyx of Held
E	0044325	molecular_function	transmembrane transporter binding
E	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050848	biological_process	regulation of calcium-mediated signaling
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
E	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
E	0071346	biological_process	cellular response to type II interferon
E	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
E	0072542	molecular_function	protein phosphatase activator activity
E	0097225	cellular_component	sperm midpiece
E	0097720	biological_process	calcineurin-mediated signaling
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0099523	cellular_component	presynaptic cytosol
E	0140056	biological_process	organelle localization by membrane tethering
E	0140238	biological_process	presynaptic endocytosis
E	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
E	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
E	1902494	cellular_component	catalytic complex
E	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
E	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
F	0005249	molecular_function	voltage-gated potassium channel activity
F	0005251	molecular_function	delayed rectifier potassium channel activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006813	biological_process	potassium ion transport
F	0006814	biological_process	sodium ion transport
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0008218	biological_process	bioluminescence
F	0015459	molecular_function	potassium channel regulator activity
F	0016020	cellular_component	membrane
F	0030425	cellular_component	dendrite
F	0030644	biological_process	intracellular chloride ion homeostasis
F	0031982	cellular_component	vesicle
F	0032809	cellular_component	neuronal cell body membrane
F	0042995	cellular_component	cell projection
F	0043204	cellular_component	perikaryon
F	0044325	molecular_function	transmembrane transporter binding
F	0045121	cellular_component	membrane raft
F	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
F	0071805	biological_process	potassium ion transmembrane transport
F	0086005	biological_process	ventricular cardiac muscle cell action potential
F	0086011	biological_process	membrane repolarization during action potential
F	0086091	biological_process	regulation of heart rate by cardiac conduction
F	0097623	biological_process	potassium ion export across plasma membrane
F	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
F	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
F	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
F	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
F	1903817	biological_process	negative regulation of voltage-gated potassium channel activity
F	1905025	biological_process	negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
F	1990794	cellular_component	basolateral part of cell
G	0005216	molecular_function	monoatomic ion channel activity
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport
H	0000086	biological_process	G2/M transition of mitotic cell cycle
H	0000922	cellular_component	spindle pole
H	0002027	biological_process	regulation of heart rate
H	0005509	molecular_function	calcium ion binding
H	0005513	biological_process	detection of calcium ion
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005876	cellular_component	spindle microtubule
H	0005886	cellular_component	plasma membrane
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
H	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
H	0010856	molecular_function	adenylate cyclase activator activity
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016240	biological_process	autophagosome membrane docking
H	0019855	molecular_function	calcium channel inhibitor activity
H	0019901	molecular_function	protein kinase binding
H	0021762	biological_process	substantia nigra development
H	0030017	cellular_component	sarcomere
H	0031432	molecular_function	titin binding
H	0031514	cellular_component	motile cilium
H	0031954	biological_process	positive regulation of protein autophosphorylation
H	0031982	cellular_component	vesicle
H	0032465	biological_process	regulation of cytokinesis
H	0032991	cellular_component	protein-containing complex
H	0034704	cellular_component	calcium channel complex
H	0035458	biological_process	cellular response to interferon-beta
H	0043209	cellular_component	myelin sheath
H	0043539	molecular_function	protein serine/threonine kinase activator activity
H	0044305	cellular_component	calyx of Held
H	0044325	molecular_function	transmembrane transporter binding
H	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050848	biological_process	regulation of calcium-mediated signaling
H	0051592	biological_process	response to calcium ion
H	0055117	biological_process	regulation of cardiac muscle contraction
H	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
H	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
H	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
H	0071346	biological_process	cellular response to type II interferon
H	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
H	0072542	molecular_function	protein phosphatase activator activity
H	0097225	cellular_component	sperm midpiece
H	0097720	biological_process	calcineurin-mediated signaling
H	0098901	biological_process	regulation of cardiac muscle cell action potential
H	0099523	cellular_component	presynaptic cytosol
H	0140056	biological_process	organelle localization by membrane tethering
H	0140238	biological_process	presynaptic endocytosis
H	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
H	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
H	1902494	cellular_component	catalytic complex
H	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
H	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
I	0005249	molecular_function	voltage-gated potassium channel activity
I	0005251	molecular_function	delayed rectifier potassium channel activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005886	cellular_component	plasma membrane
I	0006811	biological_process	monoatomic ion transport
I	0006813	biological_process	potassium ion transport
I	0006814	biological_process	sodium ion transport
I	0008076	cellular_component	voltage-gated potassium channel complex
I	0008218	biological_process	bioluminescence
I	0015459	molecular_function	potassium channel regulator activity
I	0016020	cellular_component	membrane
I	0030425	cellular_component	dendrite
I	0030644	biological_process	intracellular chloride ion homeostasis
I	0031982	cellular_component	vesicle
I	0032809	cellular_component	neuronal cell body membrane
I	0042995	cellular_component	cell projection
I	0043204	cellular_component	perikaryon
I	0044325	molecular_function	transmembrane transporter binding
I	0045121	cellular_component	membrane raft
I	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
I	0071805	biological_process	potassium ion transmembrane transport
I	0086005	biological_process	ventricular cardiac muscle cell action potential
I	0086011	biological_process	membrane repolarization during action potential
I	0086091	biological_process	regulation of heart rate by cardiac conduction
I	0097623	biological_process	potassium ion export across plasma membrane
I	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
I	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
I	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
I	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
I	1903817	biological_process	negative regulation of voltage-gated potassium channel activity
I	1905025	biological_process	negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
I	1990794	cellular_component	basolateral part of cell
J	0005216	molecular_function	monoatomic ion channel activity
J	0005249	molecular_function	voltage-gated potassium channel activity
J	0006811	biological_process	monoatomic ion transport
J	0006813	biological_process	potassium ion transport
J	0008076	cellular_component	voltage-gated potassium channel complex
J	0016020	cellular_component	membrane
J	0055085	biological_process	transmembrane transport
K	0000086	biological_process	G2/M transition of mitotic cell cycle
K	0000922	cellular_component	spindle pole
K	0002027	biological_process	regulation of heart rate
K	0005509	molecular_function	calcium ion binding
K	0005513	biological_process	detection of calcium ion
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005876	cellular_component	spindle microtubule
K	0005886	cellular_component	plasma membrane
K	0007186	biological_process	G protein-coupled receptor signaling pathway
K	0008076	cellular_component	voltage-gated potassium channel complex
K	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
K	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
K	0010856	molecular_function	adenylate cyclase activator activity
K	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K	0016020	cellular_component	membrane
K	0016240	biological_process	autophagosome membrane docking
K	0019855	molecular_function	calcium channel inhibitor activity
K	0019901	molecular_function	protein kinase binding
K	0021762	biological_process	substantia nigra development
K	0030017	cellular_component	sarcomere
K	0031432	molecular_function	titin binding
K	0031514	cellular_component	motile cilium
K	0031954	biological_process	positive regulation of protein autophosphorylation
K	0031982	cellular_component	vesicle
K	0032465	biological_process	regulation of cytokinesis
K	0032991	cellular_component	protein-containing complex
K	0034704	cellular_component	calcium channel complex
K	0035458	biological_process	cellular response to interferon-beta
K	0043209	cellular_component	myelin sheath
K	0043539	molecular_function	protein serine/threonine kinase activator activity
K	0044305	cellular_component	calyx of Held
K	0044325	molecular_function	transmembrane transporter binding
K	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
K	0046872	molecular_function	metal ion binding
K	0048306	molecular_function	calcium-dependent protein binding
K	0050848	biological_process	regulation of calcium-mediated signaling
K	0051592	biological_process	response to calcium ion
K	0055117	biological_process	regulation of cardiac muscle contraction
K	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
K	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
K	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
K	0071346	biological_process	cellular response to type II interferon
K	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
K	0072542	molecular_function	protein phosphatase activator activity
K	0097225	cellular_component	sperm midpiece
K	0097720	biological_process	calcineurin-mediated signaling
K	0098901	biological_process	regulation of cardiac muscle cell action potential
K	0099523	cellular_component	presynaptic cytosol
K	0140056	biological_process	organelle localization by membrane tethering
K	0140238	biological_process	presynaptic endocytosis
K	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
K	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
K	1902494	cellular_component	catalytic complex
K	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
K	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
L	0005249	molecular_function	voltage-gated potassium channel activity
L	0005251	molecular_function	delayed rectifier potassium channel activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005886	cellular_component	plasma membrane
L	0006811	biological_process	monoatomic ion transport
L	0006813	biological_process	potassium ion transport
L	0006814	biological_process	sodium ion transport
L	0008076	cellular_component	voltage-gated potassium channel complex
L	0008218	biological_process	bioluminescence
L	0015459	molecular_function	potassium channel regulator activity
L	0016020	cellular_component	membrane
L	0030425	cellular_component	dendrite
L	0030644	biological_process	intracellular chloride ion homeostasis
L	0031982	cellular_component	vesicle
L	0032809	cellular_component	neuronal cell body membrane
L	0042995	cellular_component	cell projection
L	0043204	cellular_component	perikaryon
L	0044325	molecular_function	transmembrane transporter binding
L	0045121	cellular_component	membrane raft
L	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
L	0071805	biological_process	potassium ion transmembrane transport
L	0086005	biological_process	ventricular cardiac muscle cell action potential
L	0086011	biological_process	membrane repolarization during action potential
L	0086091	biological_process	regulation of heart rate by cardiac conduction
L	0097623	biological_process	potassium ion export across plasma membrane
L	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
L	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
L	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
L	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
L	1903817	biological_process	negative regulation of voltage-gated potassium channel activity
L	1905025	biological_process	negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
L	1990794	cellular_component	basolateral part of cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA B 201

Chain	Residue
B	ASP21
B	ASP23
B	ASP25
B	THR27
B	GLU32

site_id	AC2
Number of Residues	3
Details	binding site for residue CA B 202

Chain	Residue
B	ASN61
B	THR63
B	GLU68

site_id	AC3
Number of Residues	5
Details	binding site for residue CA E 201

Chain	Residue
E	ASP23
E	ASP25
E	THR27
E	GLU32
E	ASP21

site_id	AC4
Number of Residues	3
Details	binding site for residue CA E 202

Chain	Residue
E	ASN61
E	THR63
E	GLU68

site_id	AC5
Number of Residues	5
Details	binding site for residue CA H 201

Chain	Residue
H	ASP21
H	ASP23
H	ASP25
H	THR27
H	GLU32

site_id	AC6
Number of Residues	3
Details	binding site for residue CA H 202

Chain	Residue
H	ASN61
H	THR63
H	GLU68

site_id	AC7
Number of Residues	5
Details	binding site for residue CA K 201

Chain	Residue
K	ASP21
K	ASP23
K	ASP25
K	THR27
K	GLU32

site_id	AC8
Number of Residues	3
Details	binding site for residue CA K 202

Chain	Residue
K	ASN61
K	THR63
K	GLU68

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
B	ASP21-LEU33
B	ASP57-PHE69
B	ASP94-LEU106
B	ASP130-PHE142

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	TYR58-GLY78
B	GLU68
E	ASP21
E	ASP23
E	ASP25
E	THR27
E	GLU32
E	ASP57
E	ASP59
E	ASN61
E	THR63
F	TYR58-GLY78
E	GLU68
H	ASP21
H	ASP23
H	ASP25
H	THR27
H	GLU32
H	ASP57
H	ASP59
H	ASN61
H	THR63
I	TYR58-GLY78
H	GLU68
K	ASP21
K	ASP23
K	ASP25
K	THR27
K	GLU32
K	ASP57
K	ASP59
K	ASN61
K	THR63
L	TYR58-GLY78
K	GLU68
B	GLU32
B	ASP57
B	ASP59
B	ASN61
B	THR63

site_id	SWS_FT_FI2
Number of Residues	96
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
C	TYR79-ILE103
E	GLU105
H	ASP94
H	ASP96
H	ASN98
H	TYR100
H	GLU105
K	ASP94
K	ASP96
K	ASN98
K	TYR100
F	TYR79-ILE103
K	GLU105
I	TYR79-ILE103
L	TYR79-ILE103
B	GLU105
E	ASP94
E	ASP96
E	ASN98
E	TYR100

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN5
L	ASN5
L	ASN22
L	ASN41
H	ASP134
H	GLN136
H	GLU141
K	ASP130
K	ASP132
K	ASP134
K	GLN136
C	ASN22
K	GLU141
C	ASN41
F	ASN5
F	ASN22
F	ASN41
I	ASN5
I	ASN22
I	ASN41

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000269\|PubMed:7093203, ECO:0000269\|Ref.7, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
B	ALA2
E	ALA2
H	ALA2
K	ALA2
G	THR169-LYS196
G	ARG249-GLU261
J	THR169-LYS196
J	ARG249-GLU261

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
B	LYS22
E	LYS22
H	LYS22
K	LYS22

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250\|UniProtKB:P0DP29

Chain	Residue	Details
B	THR45
E	THR45
H	THR45
K	THR45

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
B	SER82
E	SER82
H	SER82
K	SER82

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
B	LYS95
E	LYS95
H	LYS95
K	LYS95

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332

Chain	Residue	Details
B	TYR100
E	TYR100
H	TYR100
K	TYR100

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
B	SER102
E	SER102
H	SER102
K	SER102
G	SER407
G	SER409
J	SER407
J	SER409

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
B	THR111
E	THR111
H	THR111
K	THR111

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744\|PubMed:24129315

Chain	Residue	Details
B	LYS116
E	LYS116
H	LYS116
K	LYS116

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
B	TYR139
E	TYR139
H	TYR139
K	TYR139

site_id	SWS_FT_FI14
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P62157

Chain	Residue	Details
B	LYS22
E	LYS22
H	LYS22
K	LYS22

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)