6UYH
Crystal structure of prolyl-tRNA synthetase from Naegleria fowleri in complex with halofuginone and AMPPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| A | 0017101 | cellular_component | aminoacyl-tRNA synthetase multienzyme complex |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004827 | molecular_function | proline-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| B | 0017101 | cellular_component | aminoacyl-tRNA synthetase multienzyme complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue ANP A 601 |
| Chain | Residue |
| A | ARG142 |
| A | GLY229 |
| A | THR230 |
| A | SER264 |
| A | ARG266 |
| A | HFG602 |
| A | MG603 |
| A | HOH726 |
| A | HOH733 |
| A | HOH785 |
| A | HOH834 |
| A | GLU144 |
| A | HOH905 |
| A | HOH1001 |
| A | HOH1019 |
| A | PHE151 |
| A | ILE152 |
| A | ARG153 |
| A | SER154 |
| A | PHE157 |
| A | TRP159 |
| A | GLN227 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue HFG A 602 |
| Chain | Residue |
| A | PHE87 |
| A | GLU90 |
| A | VAL91 |
| A | PRO110 |
| A | THR111 |
| A | GLU113 |
| A | ARG142 |
| A | TRP159 |
| A | PHE206 |
| A | HIS232 |
| A | TRP261 |
| A | GLY262 |
| A | ANP601 |
| A | HOH709 |
| A | HOH834 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 603 |
| Chain | Residue |
| A | ARG142 |
| A | ANP601 |
| A | HOH733 |
| A | HOH800 |
| A | HOH834 |
| A | HOH1019 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 604 |
| Chain | Residue |
| A | GLN103 |
| A | GLU104 |
| A | HOH821 |
| A | HOH890 |
| B | TRP143 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 605 |
| Chain | Residue |
| A | HOH878 |
| A | HOH926 |
| A | HOH955 |
| B | SER396 |
| B | ASN399 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | GLN11 |
| A | HOH750 |
| B | ARG413 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 607 |
| Chain | Residue |
| A | HOH717 |
| A | HOH844 |
| B | HIS433 |
| B | LYS493 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 608 |
| Chain | Residue |
| A | LYS122 |
| A | GLU481 |
| A | GLY482 |
| A | LYS494 |
| A | HOH742 |
| A | HOH748 |
| A | HOH819 |
| B | HOH817 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 609 |
| Chain | Residue |
| A | LYS60 |
| A | LEU61 |
| A | HOH987 |
| A | HOH1017 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 610 |
| Chain | Residue |
| A | TYR30 |
| A | TYR31 |
| A | VAL33 |
| A | SER34 |
| A | GLY35 |
| A | CYS36 |
| A | TYR37 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 611 |
| Chain | Residue |
| B | ARG367 |
| B | GLU372 |
| B | TRP374 |
| B | LYS392 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 612 |
| Chain | Residue |
| A | HOH807 |
| B | PHE14 |
| B | SER15 |
| B | TYR18 |
| B | THR459 |
| B | TYR505 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 613 |
| Chain | Residue |
| A | TRP143 |
| A | ARG155 |
| B | LEU102 |
| B | GLN103 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 614 |
| Chain | Residue |
| A | LYS146 |
| A | LYS466 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 615 |
| Chain | Residue |
| A | EDO616 |
| A | ARG286 |
| A | LYS387 |
| A | LEU390 |
| A | ASP391 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 616 |
| Chain | Residue |
| A | GLN291 |
| A | GLY322 |
| A | LYS387 |
| A | EDO615 |
| A | HOH766 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 701 |
| Chain | Residue |
| A | PHE14 |
| A | SER15 |
| A | TYR18 |
| A | MET273 |
| A | THR459 |
| A | TYR505 |
| B | HOH858 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 702 |
| Chain | Residue |
| B | ARG286 |
| B | LYS387 |
| B | LEU390 |
| B | ASP391 |
| B | EDO707 |
| B | HOH927 |
| B | HOH1090 |
| site_id | AE1 |
| Number of Residues | 24 |
| Details | binding site for residue ANP B 703 |
| Chain | Residue |
| B | ARG142 |
| B | GLU144 |
| B | PHE151 |
| B | ILE152 |
| B | ARG153 |
| B | SER154 |
| B | PHE157 |
| B | TRP159 |
| B | GLN227 |
| B | THR230 |
| B | SER264 |
| B | ARG266 |
| B | HFG704 |
| B | MG705 |
| B | HOH804 |
| B | HOH812 |
| B | HOH830 |
| B | HOH834 |
| B | HOH869 |
| B | HOH878 |
| B | HOH907 |
| B | HOH967 |
| B | HOH973 |
| B | HOH1055 |
| site_id | AE2 |
| Number of Residues | 15 |
| Details | binding site for residue HFG B 704 |
| Chain | Residue |
| B | PHE87 |
| B | GLU90 |
| B | VAL91 |
| B | PRO110 |
| B | THR111 |
| B | GLU113 |
| B | ARG142 |
| B | TRP159 |
| B | PHE206 |
| B | HIS232 |
| B | TRP261 |
| B | GLY262 |
| B | ANP703 |
| B | HOH850 |
| B | HOH967 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 705 |
| Chain | Residue |
| B | ANP703 |
| B | HOH830 |
| B | HOH895 |
| B | HOH967 |
| B | HOH1055 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 706 |
| Chain | Residue |
| A | ARG330 |
| A | ARG333 |
| A | TRP337 |
| B | ARG128 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 707 |
| Chain | Residue |
| B | GLN291 |
| B | GLY322 |
| B | LYS387 |
| B | EDO702 |
| B | HOH945 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 708 |
| Chain | Residue |
| A | SER396 |
| A | ASN399 |
| B | HOH1006 |
| B | HOH1169 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 709 |
| Chain | Residue |
| A | ARG413 |
| B | HOH891 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 710 |
| Chain | Residue |
| A | HIS492 |
| B | TYR30 |
| B | TYR31 |
| B | VAL33 |
| B | SER34 |
| B | GLY35 |
| B | CYS36 |
| B | TYR37 |
| B | HOH900 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 711 |
| Chain | Residue |
| A | ARG367 |
| A | GLU372 |
| A | TRP374 |
| A | LYS392 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 712 |
| Chain | Residue |
| A | THR334 |
| A | PRO335 |
| A | GLY336 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 713 |
| Chain | Residue |
| A | LEU132 |
| B | ARG40 |
| B | PRO41 |
