6UXW

SWI/SNF nucleosome complex with ADP-BeFx

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000182	molecular_function	rDNA binding
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0006261	biological_process	DNA-templated DNA replication
A	0006302	biological_process	double-strand break repair
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016514	cellular_component	SWI/SNF complex
A	0016787	molecular_function	hydrolase activity
A	0031492	molecular_function	nucleosomal DNA binding
A	0031496	biological_process	positive regulation of mating type switching
A	0031507	biological_process	heterochromatin formation
A	0034198	biological_process	cellular response to amino acid starvation
A	0035973	biological_process	aggrephagy
A	0042148	biological_process	DNA strand invasion
A	0042393	molecular_function	histone binding
A	0045815	biological_process	transcription initiation-coupled chromatin remodeling
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070577	molecular_function	lysine-acetylated histone binding
A	0140566	molecular_function	histone reader activity
A	0140658	molecular_function	ATP-dependent chromatin remodeler activity
A	0140750	molecular_function	nucleosome array spacer activity
A	1900189	biological_process	positive regulation of cell adhesion involved in single-species biofilm formation
A	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
B	0000785	cellular_component	chromatin
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003677	molecular_function	DNA binding
B	0005634	cellular_component	nucleus
B	0006261	biological_process	DNA-templated DNA replication
B	0006338	biological_process	chromatin remodeling
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0008270	molecular_function	zinc ion binding
B	0016514	cellular_component	SWI/SNF complex
B	0031496	biological_process	positive regulation of mating type switching
B	0034198	biological_process	cellular response to amino acid starvation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046872	molecular_function	metal ion binding
B	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0000228	cellular_component	nuclear chromosome
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000785	cellular_component	chromatin
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006338	biological_process	chromatin remodeling
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0016514	cellular_component	SWI/SNF complex
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0045991	biological_process	carbon catabolite activation of transcription
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
D	0000785	cellular_component	chromatin
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005829	cellular_component	cytosol
D	0006338	biological_process	chromatin remodeling
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016514	cellular_component	SWI/SNF complex
D	0031496	biological_process	positive regulation of mating type switching
D	0042393	molecular_function	histone binding
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0000785	cellular_component	chromatin
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005829	cellular_component	cytosol
E	0006338	biological_process	chromatin remodeling
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0016514	cellular_component	SWI/SNF complex
E	0031496	biological_process	positive regulation of mating type switching
E	0042393	molecular_function	histone binding
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0000785	cellular_component	chromatin
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005829	cellular_component	cytosol
F	0006338	biological_process	chromatin remodeling
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0016514	cellular_component	SWI/SNF complex
F	0031496	biological_process	positive regulation of mating type switching
F	0042393	molecular_function	histone binding
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0000785	cellular_component	chromatin
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005829	cellular_component	cytosol
G	0006338	biological_process	chromatin remodeling
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0016514	cellular_component	SWI/SNF complex
G	0031496	biological_process	positive regulation of mating type switching
G	0042393	molecular_function	histone binding
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0000785	cellular_component	chromatin
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005829	cellular_component	cytosol
H	0006338	biological_process	chromatin remodeling
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0016514	cellular_component	SWI/SNF complex
H	0030527	molecular_function	structural constituent of chromatin
H	0034198	biological_process	cellular response to amino acid starvation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
P	0000785	cellular_component	chromatin
P	0003674	molecular_function	molecular_function
P	0003682	molecular_function	chromatin binding
P	0005198	molecular_function	structural molecule activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0006325	biological_process	chromatin organization
P	0006337	biological_process	nucleosome disassembly
P	0006338	biological_process	chromatin remodeling
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0006368	biological_process	transcription elongation by RNA polymerase II
P	0016514	cellular_component	SWI/SNF complex
P	0016586	cellular_component	RSC-type complex
P	0035267	cellular_component	NuA4 histone acetyltransferase complex
P	0043232	cellular_component	intracellular non-membrane-bounded organelle
P	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0000785	cellular_component	chromatin
Q	0005198	molecular_function	structural molecule activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0006325	biological_process	chromatin organization
Q	0006337	biological_process	nucleosome disassembly
Q	0006338	biological_process	chromatin remodeling
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0016514	cellular_component	SWI/SNF complex
Q	0016586	cellular_component	RSC-type complex
Q	0043232	cellular_component	intracellular non-membrane-bounded organelle
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0000786	cellular_component	nucleosome
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0030527	molecular_function	structural constituent of chromatin
R	0046982	molecular_function	protein heterodimerization activity
S	0000786	cellular_component	nucleosome
S	0003677	molecular_function	DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005694	cellular_component	chromosome
S	0030527	molecular_function	structural constituent of chromatin
S	0046982	molecular_function	protein heterodimerization activity
T	0000786	cellular_component	nucleosome
T	0003677	molecular_function	DNA binding
T	0005634	cellular_component	nucleus
T	0005694	cellular_component	chromosome
T	0030527	molecular_function	structural constituent of chromatin
T	0046982	molecular_function	protein heterodimerization activity
U	0000786	cellular_component	nucleosome
U	0003677	molecular_function	DNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005694	cellular_component	chromosome
U	0030527	molecular_function	structural constituent of chromatin
U	0046982	molecular_function	protein heterodimerization activity
V	0000786	cellular_component	nucleosome
V	0003677	molecular_function	DNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005694	cellular_component	chromosome
V	0030527	molecular_function	structural constituent of chromatin
V	0046982	molecular_function	protein heterodimerization activity
W	0000786	cellular_component	nucleosome
W	0003677	molecular_function	DNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005694	cellular_component	chromosome
W	0030527	molecular_function	structural constituent of chromatin
W	0046982	molecular_function	protein heterodimerization activity
X	0000786	cellular_component	nucleosome
X	0003677	molecular_function	DNA binding
X	0005634	cellular_component	nucleus
X	0005694	cellular_component	chromosome
X	0030527	molecular_function	structural constituent of chromatin
X	0046982	molecular_function	protein heterodimerization activity
Y	0000786	cellular_component	nucleosome
Y	0003677	molecular_function	DNA binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005694	cellular_component	chromosome
Y	0030527	molecular_function	structural constituent of chromatin
Y	0046982	molecular_function	protein heterodimerization activity
Z	0000785	cellular_component	chromatin
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0006337	biological_process	nucleosome disassembly
Z	0006338	biological_process	chromatin remodeling
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0006368	biological_process	transcription elongation by RNA polymerase II
Z	0007059	biological_process	chromosome segregation
Z	0015616	molecular_function	DNA translocase activity
Z	0016514	cellular_component	SWI/SNF complex
Z	0016586	cellular_component	RSC-type complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PO4 P 501

Chain	Residue
P	HIS15
P	ASP190
P	ALA224
P	GLN229
P	LYS232
P	PO4503
P	HOH608

---

site_id	AC2
Number of Residues	2
Details	binding site for residue PO4 P 502

Chain	Residue
P	ASN53
P	TYR89

---

site_id	AC3
Number of Residues	11
Details	binding site for residue PO4 P 503

Chain	Residue
P	HIS15
P	ARG16
P	ALA161
P	GLY186
P	LYS232
P	SER397
P	THR398
P	PO4501
P	HOH602
P	HOH603
P	HOH608

---

site_id	AC4
Number of Residues	7
Details	binding site for residue PO4 P 504

Chain	Residue
P	HIS11
P	GLY13
P	GLU141
P	PO4505
P	HOH601
P	HOH602
P	HOH612

---

site_id	AC5
Number of Residues	6
Details	binding site for residue PO4 P 505

Chain	Residue
P	SER14
P	ASP158
P	SER162
P	ASN165
P	ARG181
P	PO4504

---

site_id	AC6
Number of Residues	7
Details	binding site for residue PO4 Q 501

Chain	Residue
Q	SER16
Q	GLN17
Q	ASN70
Q	GLY71
Q	THR166
Q	HIS167
Q	HIS168

---

site_id	AC7
Number of Residues	4
Details	binding site for residue PO4 Q 502

Chain	Residue
Q	ARG15
Q	GLY338
Q	SER425
Q	GLU426

---

site_id	AC8
Number of Residues	4
Details	binding site for residue PO4 Q 503

Chain	Residue
Q	GLY344
Q	LYS346
Q	HOH605
Q	HOH616

---

site_id	AC9
Number of Residues	4
Details	binding site for residue PO4 Q 504

Chain	Residue
Q	ARG15
Q	ASP163
Q	GLY338
Q	HOH601

---

site_id	AD1
Number of Residues	4
Details	binding site for residue PO4 Q 505

Chain	Residue
Q	ASP206
Q	ASP208
Q	ASP286
Q	LYS288

---

site_id	AD2
Number of Residues	5
Details	binding site for residue PO4 Q 506

Chain	Residue
P	LYS293
Q	GLY314
Q	ASP318
Q	ASP356
Q	HIS357

---

site_id	AD3
Number of Residues	2
Details	binding site for residue PO4 A 1801

Chain	Residue
A	ARG619
P	ASP431

---

site_id	AD4
Number of Residues	14
Details	binding site for residue ADP A 1802

Chain	Residue
A	THR766
A	LYS768
A	TYR770
A	GLY795
A	GLY797
A	LYS798
A	THR799
A	ILE800
A	TRP838
A	ASN1171
A	GLN1173
A	ILE1200
A	BEF1803
A	MG1804

---

site_id	AD5
Number of Residues	5
Details	binding site for residue BEF A 1803

Chain	Residue
A	ASN1171
A	ARG1196
A	ARG1199
A	ADP1802
A	MG1804

---

site_id	AD6
Number of Residues	3
Details	binding site for residue MG A 1804

Chain	Residue
A	GLU895
A	ADP1802
A	BEF1803

---

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
T	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
S	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
R	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
U	ARG89-GLY111

---

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SdiFlskpSkalyp..DYYmiIkypVafdnInthietla..Ynslketlqdfhl.IfsNAriY

Chain	Residue	Details
A	SER1573-TYR1630

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
R	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
D	SER88
G	SER88
G	SER185
G	SER657
D	SER185
D	SER657
E	SER88
E	SER185
E	SER657
F	SER88
F	SER185
F	SER657

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
D	THR235
E	THR235
F	THR235
G	THR235

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	DNA_BIND: A.T hook 3

Chain	Residue	Details
A	GLY1516-LYS1526
Y	SER109
X	LYS9
X	LYS95

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	ASP792
X	LYS36
Y	LYS117

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER358
T	LYS75
X	LYS74
X	LYS75
W	LYS8
W	LYS16
W	LYS44
W	LYS79

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	THR383
X	GLN104
W	LYS12
W	LYS20

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER716
X	LYS118
W	LYS31
W	LYS91

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	SER1340
W	SER47
T	LYS15
T	LYS119
X	LYS13
X	LYS15
X	LYS119

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
A	LYS543
S	TYR88
W	TYR51
W	TYR88

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
S	LYS59
V	LYS64
W	LYS59
R	LYS27
R	LYS36
R	LYS64
V	LYS18
V	LYS23
V	LYS27
V	LYS36

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
S	LYS77
W	LYS77

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
S	LYS31
W	LYS31

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
R	LYS37
S	LYS91
W	LYS91

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
R	TYR41
V	TYR41

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
R	LYS56
R	LYS79
V	LYS56
V	LYS79

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
R	SER57
V	SER57

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
R	THR80
R	THR107
V	THR80
V	THR107

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
R	SER86
V	SER86

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
R	LYS115
V	LYS115

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
R	LYS122
V	LYS122

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
R	CYS110
V	CYS110

---