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6UXL

Structure of serine hydroxymethyltransferase 8 from Glycine max cultivar Forrest complexed with PLP-Glycine

Functional Information from GO Data
ChainGOidnamespacecontents
A0000900molecular_functionmRNA regulatory element binding translation repressor activity
A0004372molecular_functionglycine hydroxymethyltransferase activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006565biological_processL-serine catabolic process
A0006730biological_processone-carbon metabolic process
A0008168molecular_functionmethyltransferase activity
A0008270molecular_functionzinc ion binding
A0009113biological_processpurine nucleobase biosynthetic process
A0009507cellular_componentchloroplast
A0017148biological_processnegative regulation of translation
A0019264biological_processglycine biosynthetic process from serine
A0030170molecular_functionpyridoxal phosphate binding
A0032259biological_processmethylation
A0035999biological_processtetrahydrofolate interconversion
A0042803molecular_functionprotein homodimerization activity
A0046655biological_processfolic acid metabolic process
A0048027molecular_functionmRNA 5'-UTR binding
A0050897molecular_functioncobalt ion binding
A0051289biological_processprotein homotetramerization
A0070905molecular_functionserine binding
A1990830biological_processcellular response to leukemia inhibitory factor
B0000900molecular_functionmRNA regulatory element binding translation repressor activity
B0004372molecular_functionglycine hydroxymethyltransferase activity
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006565biological_processL-serine catabolic process
B0006730biological_processone-carbon metabolic process
B0008168molecular_functionmethyltransferase activity
B0008270molecular_functionzinc ion binding
B0009113biological_processpurine nucleobase biosynthetic process
B0009507cellular_componentchloroplast
B0017148biological_processnegative regulation of translation
B0019264biological_processglycine biosynthetic process from serine
B0030170molecular_functionpyridoxal phosphate binding
B0032259biological_processmethylation
B0035999biological_processtetrahydrofolate interconversion
B0042803molecular_functionprotein homodimerization activity
B0046655biological_processfolic acid metabolic process
B0048027molecular_functionmRNA 5'-UTR binding
B0050897molecular_functioncobalt ion binding
B0051289biological_processprotein homotetramerization
B0070905molecular_functionserine binding
B1990830biological_processcellular response to leukemia inhibitory factor
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue PLG A 501
ChainResidue
ASER39
AHIS218
ATHR241
AHIS243
ALYS244
AARG389
BTYR59
BTYR69
BGLY289
BGLY290
ASER105
AGLY106
ASER107
AHIS134
AGLY189
ASER190
AASP215
AALA217

site_idAC2
Number of Residues20
Detailsbinding site for residue PLG B 501
ChainResidue
ATYR59
AGLU61
ATYR69
ATYR104
AGLY289
AGLY290
BSER39
BSER105
BGLY106
BSER107
BHIS134
BGLY189
BSER190
BASP215
BALA217
BHIS218
BTHR241
BHIS243
BLYS244
BARG389

Functional Information from PROSITE/UniProt
site_idPS00096
Number of Residues17
DetailsSHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DIvTTTTHKSLrGPRAG
ChainResidueDetails
AASP236-GLY252

221716

PDB entries from 2024-06-26

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