6UX2
Crystal structure of ZIKV RdRp in complex with STAT2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0007165 | biological_process | signal transduction |
| B | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 801 |
| Chain | Residue |
| A | LEU232 |
| A | ARG310 |
| A | ARG314 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 802 |
| Chain | Residue |
| A | ARG148 |
| A | ARG223 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 803 |
| Chain | Residue |
| A | THR611 |
| A | ARG694 |
| A | ARG601 |
| A | SER603 |
| A | GLU604 |
| A | SER605 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 1001 |
| Chain | Residue |
| B | THR536 |
| B | ALA537 |
| B | GLY538 |
| B | LYS691 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1002 |
| Chain | Residue |
| B | GLU439 |
| B | HIS443 |
| B | CYS448 |
| B | CYS451 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1003 |
| Chain | Residue |
| B | HIS714 |
| B | CYS730 |
| B | CYS849 |
| B | HOH1124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23139419","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23139419","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by JAK","evidences":[{"source":"PubMed","id":"7532278","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9121453","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 150 |
| Details | Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Motif: {"description":"Nuclear localization signal (NLS)","evidences":[{"source":"PubMed","id":"30848123","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28291746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345656","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
