Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UW6

Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0007015	biological_process	actin filament organization
A	0007231	biological_process	osmosensory signaling pathway
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042636	biological_process	negative regulation of hair cycle
A	0042802	molecular_function	identical protein binding
A	0043235	cellular_component	receptor complex
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0090280	biological_process	positive regulation of calcium ion import
A	0098703	biological_process	calcium ion import across plasma membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0007015	biological_process	actin filament organization
B	0007231	biological_process	osmosensory signaling pathway
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042636	biological_process	negative regulation of hair cycle
B	0042802	molecular_function	identical protein binding
B	0043235	cellular_component	receptor complex
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0090280	biological_process	positive regulation of calcium ion import
B	0098703	biological_process	calcium ion import across plasma membrane
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0007015	biological_process	actin filament organization
C	0007231	biological_process	osmosensory signaling pathway
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042636	biological_process	negative regulation of hair cycle
C	0042802	molecular_function	identical protein binding
C	0043235	cellular_component	receptor complex
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0090280	biological_process	positive regulation of calcium ion import
C	0098703	biological_process	calcium ion import across plasma membrane
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0007015	biological_process	actin filament organization
D	0007231	biological_process	osmosensory signaling pathway
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042636	biological_process	negative regulation of hair cycle
D	0042802	molecular_function	identical protein binding
D	0043235	cellular_component	receptor complex
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0090280	biological_process	positive regulation of calcium ion import
D	0098703	biological_process	calcium ion import across plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 6OU A 801

Chain	Residue
A	SER444
A	LYS500
A	GLU501
A	HIS523
A	PHE526
A	TYR564
A	TYR565
A	PHE703
A	MET706

site_id	AC2
Number of Residues	1
Details	binding site for residue 6OU A 802

Chain	Residue
A	GLU546

site_id	AC3
Number of Residues	6
Details	binding site for residue 6OU A 803

Chain	Residue
A	SER626
A	LEU630
A	PHE633
D	ILE644
D	LEU655
D	PHE656

site_id	AC4
Number of Residues	5
Details	binding site for residue 6OU A 804

Chain	Residue
A	SER624
A	PHE625
A	SER626
B	LEU457
B	TYR460

site_id	AC5
Number of Residues	9
Details	binding site for residue 6OU B 801

Chain	Residue
B	SER444
B	LYS500
B	GLU501
B	HIS523
B	PHE526
B	TYR564
B	TYR565
B	PHE703
B	MET706

site_id	AC6
Number of Residues	1
Details	binding site for residue 6OU B 802

Chain	Residue
B	GLU546

site_id	AC7
Number of Residues	5
Details	binding site for residue 6OU B 803

Chain	Residue
A	ILE644
A	LEU655
B	SER626
B	LEU630
B	PHE633

site_id	AC8
Number of Residues	5
Details	binding site for residue 6OU B 804

Chain	Residue
B	SER624
B	PHE625
B	SER626
C	LEU457
C	TYR460

site_id	AC9
Number of Residues	9
Details	binding site for residue 6OU C 801

Chain	Residue
C	SER444
C	LYS500
C	GLU501
C	HIS523
C	PHE526
C	TYR564
C	TYR565
C	PHE703
C	MET706

site_id	AD1
Number of Residues	1
Details	binding site for residue 6OU C 802

Chain	Residue
C	GLU546

site_id	AD2
Number of Residues	6
Details	binding site for residue 6OU C 803

Chain	Residue
B	ILE644
B	LEU655
B	PHE656
C	SER626
C	LEU630
C	PHE633

site_id	AD3
Number of Residues	5
Details	binding site for residue 6OU C 804

Chain	Residue
C	SER624
C	PHE625
C	SER626
D	LEU457
D	TYR460

site_id	AD4
Number of Residues	9
Details	binding site for residue 6OU D 801

Chain	Residue
D	SER444
D	LYS500
D	GLU501
D	HIS523
D	PHE526
D	TYR564
D	TYR565
D	PHE703
D	MET706

site_id	AD5
Number of Residues	1
Details	binding site for residue 6OU D 802

Chain	Residue
D	GLU546

site_id	AD6
Number of Residues	6
Details	binding site for residue 6OU D 803

Chain	Residue
C	ILE644
C	LEU655
C	PHE656
D	SER626
D	LEU630
D	PHE633

site_id	AD7
Number of Residues	6
Details	binding site for residue 6OU D 804

Chain	Residue
A	ILE453
A	LEU457
A	TYR460
D	SER624
D	PHE625
D	SER626

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	24
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	152
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	100
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	144
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	124
Details	Repeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	112
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	116
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	120
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	128
Details	Repeat: {"description":"ANK 5","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	88
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	88
Details	Repeat: {"description":"ANK 7","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)