6UW6
Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0009266 | biological_process | response to temperature stimulus |
| A | 0016020 | cellular_component | membrane |
| A | 0042636 | biological_process | negative regulation of hair cycle |
| A | 0043235 | cellular_component | receptor complex |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0090280 | biological_process | positive regulation of calcium ion import |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005764 | cellular_component | lysosome |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0009266 | biological_process | response to temperature stimulus |
| B | 0016020 | cellular_component | membrane |
| B | 0042636 | biological_process | negative regulation of hair cycle |
| B | 0043235 | cellular_component | receptor complex |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0090280 | biological_process | positive regulation of calcium ion import |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005764 | cellular_component | lysosome |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0009266 | biological_process | response to temperature stimulus |
| C | 0016020 | cellular_component | membrane |
| C | 0042636 | biological_process | negative regulation of hair cycle |
| C | 0043235 | cellular_component | receptor complex |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0090280 | biological_process | positive regulation of calcium ion import |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005764 | cellular_component | lysosome |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0009266 | biological_process | response to temperature stimulus |
| D | 0016020 | cellular_component | membrane |
| D | 0042636 | biological_process | negative regulation of hair cycle |
| D | 0043235 | cellular_component | receptor complex |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0090280 | biological_process | positive regulation of calcium ion import |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue 6OU A 801 |
| Chain | Residue |
| A | SER444 |
| A | LYS500 |
| A | GLU501 |
| A | HIS523 |
| A | PHE526 |
| A | TYR564 |
| A | TYR565 |
| A | PHE703 |
| A | MET706 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue 6OU A 802 |
| Chain | Residue |
| A | GLU546 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue 6OU A 803 |
| Chain | Residue |
| A | SER626 |
| A | LEU630 |
| A | PHE633 |
| D | ILE644 |
| D | LEU655 |
| D | PHE656 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue 6OU A 804 |
| Chain | Residue |
| A | SER624 |
| A | PHE625 |
| A | SER626 |
| B | LEU457 |
| B | TYR460 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue 6OU B 801 |
| Chain | Residue |
| B | SER444 |
| B | LYS500 |
| B | GLU501 |
| B | HIS523 |
| B | PHE526 |
| B | TYR564 |
| B | TYR565 |
| B | PHE703 |
| B | MET706 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue 6OU B 802 |
| Chain | Residue |
| B | GLU546 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue 6OU B 803 |
| Chain | Residue |
| A | ILE644 |
| A | LEU655 |
| B | SER626 |
| B | LEU630 |
| B | PHE633 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue 6OU B 804 |
| Chain | Residue |
| B | SER624 |
| B | PHE625 |
| B | SER626 |
| C | LEU457 |
| C | TYR460 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue 6OU C 801 |
| Chain | Residue |
| C | SER444 |
| C | LYS500 |
| C | GLU501 |
| C | HIS523 |
| C | PHE526 |
| C | TYR564 |
| C | TYR565 |
| C | PHE703 |
| C | MET706 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue 6OU C 802 |
| Chain | Residue |
| C | GLU546 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue 6OU C 803 |
| Chain | Residue |
| B | ILE644 |
| B | LEU655 |
| B | PHE656 |
| C | SER626 |
| C | LEU630 |
| C | PHE633 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue 6OU C 804 |
| Chain | Residue |
| C | SER624 |
| C | PHE625 |
| C | SER626 |
| D | LEU457 |
| D | TYR460 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue 6OU D 801 |
| Chain | Residue |
| D | SER444 |
| D | LYS500 |
| D | GLU501 |
| D | HIS523 |
| D | PHE526 |
| D | TYR564 |
| D | TYR565 |
| D | PHE703 |
| D | MET706 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue 6OU D 802 |
| Chain | Residue |
| D | GLU546 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue 6OU D 803 |
| Chain | Residue |
| C | ILE644 |
| C | LEU655 |
| C | PHE656 |
| D | SER626 |
| D | LEU630 |
| D | PHE633 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue 6OU D 804 |
| Chain | Residue |
| A | ILE453 |
| A | LEU457 |
| A | TYR460 |
| D | SER624 |
| D | PHE625 |
| D | SER626 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2372 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-HIS439 | |
| C | ARG509-HIS523 | |
| C | ARG567-LYS589 | |
| C | ASN671-VAL790 | |
| D | MET1-HIS439 | |
| D | ARG509-HIS523 | |
| D | ARG567-LYS589 | |
| D | ASN671-VAL790 | |
| A | ARG509-HIS523 | |
| A | ARG567-LYS589 | |
| A | ASN671-VAL790 | |
| B | MET1-HIS439 | |
| B | ARG509-HIS523 | |
| B | ARG567-LYS589 | |
| B | ASN671-VAL790 | |
| C | MET1-HIS439 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 480 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | MET440-TYR460 | |
| B | GLU546-THR566 | |
| B | PHE590-GLU610 | |
| B | TYR650-LEU670 | |
| C | MET440-TYR460 | |
| C | MET488-LEU508 | |
| C | PHE524-TYR544 | |
| C | GLU546-THR566 | |
| C | PHE590-GLU610 | |
| C | TYR650-LEU670 | |
| D | MET440-TYR460 | |
| A | MET488-LEU508 | |
| D | MET488-LEU508 | |
| D | PHE524-TYR544 | |
| D | GLU546-THR566 | |
| D | PHE590-GLU610 | |
| D | TYR650-LEU670 | |
| A | PHE524-TYR544 | |
| A | GLU546-THR566 | |
| A | PHE590-GLU610 | |
| A | TYR650-LEU670 | |
| B | MET440-TYR460 | |
| B | MET488-LEU508 | |
| B | PHE524-TYR544 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 108 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR461-ARG487 | |
| A | LYS545 | |
| B | TYR461-ARG487 | |
| B | LYS545 | |
| C | TYR461-ARG487 | |
| C | LYS545 | |
| D | TYR461-ARG487 | |
| D | LYS545 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 64 |
| Details | INTRAMEM: Pore-forming => ECO:0000255 |
| Chain | Residue | Details |
| A | SER621-ILE637 | |
| B | SER621-ILE637 | |
| C | SER621-ILE637 | |
| D | SER621-ILE637 |
