Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UW4

Cryo-EM structure of human TRPV3 determined in lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0009266	biological_process	response to temperature stimulus
A	0016020	cellular_component	membrane
A	0042636	biological_process	negative regulation of hair cycle
A	0043235	cellular_component	receptor complex
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0090280	biological_process	positive regulation of calcium ion import
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0009266	biological_process	response to temperature stimulus
B	0016020	cellular_component	membrane
B	0042636	biological_process	negative regulation of hair cycle
B	0043235	cellular_component	receptor complex
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0090280	biological_process	positive regulation of calcium ion import
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0009266	biological_process	response to temperature stimulus
C	0016020	cellular_component	membrane
C	0042636	biological_process	negative regulation of hair cycle
C	0043235	cellular_component	receptor complex
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0090280	biological_process	positive regulation of calcium ion import
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0009266	biological_process	response to temperature stimulus
D	0016020	cellular_component	membrane
D	0042636	biological_process	negative regulation of hair cycle
D	0043235	cellular_component	receptor complex
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0090280	biological_process	positive regulation of calcium ion import

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 6OU A 801

Chain	Residue
A	SER444
A	TRP493
A	CYS496
A	LYS500
A	GLU501
A	HIS523
A	TYR565
A	MET706

site_id	AC2
Number of Residues	2
Details	binding site for residue 6OU A 802

Chain	Residue
D	ILE652
D	PRO651

site_id	AC3
Number of Residues	9
Details	binding site for residue 6OU A 803

Chain	Residue
A	LEU591
A	TYR594
A	SER626
A	PHE633
D	ILE644
D	GLN645
D	ILE652
D	LEU655
D	PHE666

site_id	AC4
Number of Residues	7
Details	binding site for residue 6OU A 804

Chain	Residue
A	LEU599
A	SER624
A	PHE625
A	SER626
B	TYR460
B	TYR461
B	TRP559

site_id	AC5
Number of Residues	4
Details	binding site for residue 6OU A 805

Chain	Residue
A	SER571
D	LEU584
D	HIS585
D	LYS589

site_id	AC6
Number of Residues	4
Details	binding site for residue NA A 806

Chain	Residue
A	GLY638
B	GLY638
C	GLY638
D	GLY638

site_id	AC7
Number of Residues	8
Details	binding site for residue 6OU B 801

Chain	Residue
B	SER444
B	TRP493
B	CYS496
B	LYS500
B	GLU501
B	HIS523
B	TYR565
B	MET706

site_id	AC8
Number of Residues	2
Details	binding site for residue 6OU B 802

Chain	Residue
A	PRO651
A	ILE652

site_id	AC9
Number of Residues	9
Details	binding site for residue 6OU B 803

Chain	Residue
A	ILE644
A	GLN645
A	ILE652
A	LEU655
A	PHE666
B	LEU591
B	TYR594
B	SER626
B	PHE633

site_id	AD1
Number of Residues	7
Details	binding site for residue 6OU B 804

Chain	Residue
B	LEU599
B	SER624
B	PHE625
B	SER626
C	TYR460
C	TYR461
C	TRP559

site_id	AD2
Number of Residues	4
Details	binding site for residue 6OU B 805

Chain	Residue
A	LEU584
A	HIS585
A	LYS589
B	SER571

site_id	AD3
Number of Residues	8
Details	binding site for residue 6OU C 801

Chain	Residue
C	SER444
C	TRP493
C	CYS496
C	LYS500
C	GLU501
C	HIS523
C	TYR565
C	MET706

site_id	AD4
Number of Residues	2
Details	binding site for residue 6OU C 802

Chain	Residue
B	PRO651
B	ILE652

site_id	AD5
Number of Residues	8
Details	binding site for residue 6OU C 803

Chain	Residue
B	GLN645
B	ILE652
B	LEU655
B	PHE666
C	LEU591
C	TYR594
C	SER626
C	PHE633

site_id	AD6
Number of Residues	7
Details	binding site for residue 6OU C 804

Chain	Residue
C	LEU599
C	SER624
C	PHE625
C	SER626
D	TYR460
D	TYR461
D	TRP559

site_id	AD7
Number of Residues	4
Details	binding site for residue 6OU C 805

Chain	Residue
B	LEU584
B	HIS585
B	LYS589
C	SER571

site_id	AD8
Number of Residues	8
Details	binding site for residue 6OU D 801

Chain	Residue
D	TYR565
D	MET706
D	SER444
D	TRP493
D	CYS496
D	LYS500
D	GLU501
D	HIS523

site_id	AD9
Number of Residues	2
Details	binding site for residue 6OU D 802

Chain	Residue
C	PRO651
C	ILE652

site_id	AE1
Number of Residues	8
Details	binding site for residue 6OU D 803

Chain	Residue
C	GLN645
C	ILE652
C	LEU655
C	PHE666
D	LEU591
D	TYR594
D	SER626
D	PHE633

site_id	AE2
Number of Residues	7
Details	binding site for residue 6OU D 804

Chain	Residue
A	TYR460
A	TYR461
A	TRP559
D	LEU599
D	SER624
D	PHE625
D	SER626

site_id	AE3
Number of Residues	4
Details	binding site for residue 6OU D 805

Chain	Residue
C	LEU584
C	HIS585
C	LYS589
D	SER571

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2372
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-HIS439
C	ARG509-HIS523
C	ARG567-LYS589
C	ASN671-VAL790
D	MET1-HIS439
D	ARG509-HIS523
D	ARG567-LYS589
D	ASN671-VAL790
A	ARG509-HIS523
A	ARG567-LYS589
A	ASN671-VAL790
B	MET1-HIS439
B	ARG509-HIS523
B	ARG567-LYS589
B	ASN671-VAL790
C	MET1-HIS439

site_id	SWS_FT_FI2
Number of Residues	480
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	MET440-TYR460
B	GLU546-THR566
B	PHE590-GLU610
B	TYR650-LEU670
C	MET440-TYR460
C	MET488-LEU508
C	PHE524-TYR544
C	GLU546-THR566
C	PHE590-GLU610
C	TYR650-LEU670
D	MET440-TYR460
A	MET488-LEU508
D	MET488-LEU508
D	PHE524-TYR544
D	GLU546-THR566
D	PHE590-GLU610
D	TYR650-LEU670
A	PHE524-TYR544
A	GLU546-THR566
A	PHE590-GLU610
A	TYR650-LEU670
B	MET440-TYR460
B	MET488-LEU508
B	PHE524-TYR544

site_id	SWS_FT_FI3
Number of Residues	108
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	TYR461-ARG487
A	LYS545
B	TYR461-ARG487
B	LYS545
C	TYR461-ARG487
C	LYS545
D	TYR461-ARG487
D	LYS545

site_id	SWS_FT_FI4
Number of Residues	64
Details	INTRAMEM: Pore-forming => ECO:0000255

Chain	Residue	Details
A	SER621-ILE637
B	SER621-ILE637
C	SER621-ILE637
D	SER621-ILE637

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)