Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UT6

Cryo-EM structure of the Escherichia coli McrBC complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003924	molecular_function	GTPase activity
A	0004519	molecular_function	endonuclease activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0009307	biological_process	DNA restriction-modification system
A	0010385	molecular_function	double-stranded methylated DNA binding
A	0016887	molecular_function	ATP hydrolysis activity
A	0042802	molecular_function	identical protein binding
A	0044729	molecular_function	hemi-methylated DNA-binding
A	1905348	cellular_component	endonuclease complex
B	0003677	molecular_function	DNA binding
B	0003924	molecular_function	GTPase activity
B	0004519	molecular_function	endonuclease activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0009307	biological_process	DNA restriction-modification system
B	0010385	molecular_function	double-stranded methylated DNA binding
B	0016887	molecular_function	ATP hydrolysis activity
B	0042802	molecular_function	identical protein binding
B	0044729	molecular_function	hemi-methylated DNA-binding
B	1905348	cellular_component	endonuclease complex
C	0003677	molecular_function	DNA binding
C	0003924	molecular_function	GTPase activity
C	0004519	molecular_function	endonuclease activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005525	molecular_function	GTP binding
C	0009307	biological_process	DNA restriction-modification system
C	0010385	molecular_function	double-stranded methylated DNA binding
C	0016887	molecular_function	ATP hydrolysis activity
C	0042802	molecular_function	identical protein binding
C	0044729	molecular_function	hemi-methylated DNA-binding
C	1905348	cellular_component	endonuclease complex
D	0003677	molecular_function	DNA binding
D	0003924	molecular_function	GTPase activity
D	0004519	molecular_function	endonuclease activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005525	molecular_function	GTP binding
D	0009307	biological_process	DNA restriction-modification system
D	0010385	molecular_function	double-stranded methylated DNA binding
D	0016887	molecular_function	ATP hydrolysis activity
D	0042802	molecular_function	identical protein binding
D	0044729	molecular_function	hemi-methylated DNA-binding
D	1905348	cellular_component	endonuclease complex
E	0003677	molecular_function	DNA binding
E	0003924	molecular_function	GTPase activity
E	0004519	molecular_function	endonuclease activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005525	molecular_function	GTP binding
E	0009307	biological_process	DNA restriction-modification system
E	0010385	molecular_function	double-stranded methylated DNA binding
E	0016887	molecular_function	ATP hydrolysis activity
E	0042802	molecular_function	identical protein binding
E	0044729	molecular_function	hemi-methylated DNA-binding
E	1905348	cellular_component	endonuclease complex
F	0003677	molecular_function	DNA binding
F	0003924	molecular_function	GTPase activity
F	0004519	molecular_function	endonuclease activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005525	molecular_function	GTP binding
F	0009307	biological_process	DNA restriction-modification system
F	0010385	molecular_function	double-stranded methylated DNA binding
F	0016887	molecular_function	ATP hydrolysis activity
F	0042802	molecular_function	identical protein binding
F	0044729	molecular_function	hemi-methylated DNA-binding
F	1905348	cellular_component	endonuclease complex
G	0005515	molecular_function	protein binding
G	0009307	biological_process	DNA restriction-modification system
G	0032067	molecular_function	type IV site-specific deoxyribonuclease activity
G	1905348	cellular_component	endonuclease complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue GDP A 501

Chain	Residue
A	ASP176
A	LEU177
A	PHE178
A	GLY204
A	GLY206
A	LYS207
A	THR208
A	PHE209
A	SER408

site_id	AC2
Number of Residues	17
Details	binding site for residue GSP B 501

Chain	Residue
B	ASP176
B	LEU177
B	PHE178
B	GLY204
B	VAL205
B	GLY206
B	LYS207
B	THR208
B	PHE209
B	HIS407
B	SER408
B	MG502
C	GLU298
C	ASP300
C	LYS301
C	ARG348
C	ARG349

site_id	AC3
Number of Residues	4
Details	binding site for residue MG B 502

Chain	Residue
B	THR208
B	ASP279
B	GSP501
C	ARG349

site_id	AC4
Number of Residues	18
Details	binding site for residue GSP C 501

Chain	Residue
C	ASP176
C	LEU177
C	PHE178
C	GLY204
C	VAL205
C	GLY206
C	LYS207
C	THR208
C	PHE209
C	ASN333
C	HIS407
C	SER408
C	MG502
D	GLU298
D	ASP300
D	LYS301
D	ARG348
D	ARG349

site_id	AC5
Number of Residues	3
Details	binding site for residue MG C 502

Chain	Residue
C	THR208
C	ASP279
C	GSP501

site_id	AC6
Number of Residues	19
Details	binding site for residue GSP D 501

Chain	Residue
D	ASP176
D	LEU177
D	PHE178
D	PRO203
D	GLY204
D	VAL205
D	GLY206
D	LYS207
D	THR208
D	PHE209
D	ASN333
D	HIS407
D	SER408
D	MG502
E	GLU298
E	ASP300
E	LYS301
E	ARG348
E	ARG349

site_id	AC7
Number of Residues	3
Details	binding site for residue MG D 502

Chain	Residue
D	THR208
D	ASP279
D	GSP501

site_id	AC8
Number of Residues	18
Details	binding site for residue GSP E 501

Chain	Residue
E	ASP176
E	LEU177
E	PHE178
E	GLY204
E	VAL205
E	GLY206
E	LYS207
E	THR208
E	PHE209
E	ASN333
E	HIS407
E	SER408
E	MG502
F	GLU298
F	ASP300
F	LYS301
F	ARG348
F	ARG349

site_id	AC9
Number of Residues	3
Details	binding site for residue MG E 502

Chain	Residue
E	THR208
E	ASP279
E	GSP501

site_id	AD1
Number of Residues	11
Details	binding site for residue GSP F 501

Chain	Residue
F	GLY206
F	LYS207
F	THR208
F	PHE209
F	HIS407
F	SER408
A	ASP300
A	ARG348
F	ASP176
F	PHE178
F	GLY204

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	GLY201
D	GLY201
D	ASP300
D	ASN333
E	GLY201
E	ASP300
E	ASN333
F	GLY201
F	ASP300
F	ASN333
A	ASP300
A	ASN333
B	GLY201
B	ASP300
B	ASN333
C	GLY201
C	ASP300
C	ASN333

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)