6URF

Malic enzyme from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004470	molecular_function	malic enzyme activity
A	0004471	molecular_function	malate dehydrogenase (decarboxylating) (NAD+) activity
A	0005829	cellular_component	cytosol
A	0006090	biological_process	pyruvate metabolic process
A	0006108	biological_process	malate metabolic process
A	0008948	molecular_function	oxaloacetate decarboxylase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
B	0003824	molecular_function	catalytic activity
B	0004470	molecular_function	malic enzyme activity
B	0004471	molecular_function	malate dehydrogenase (decarboxylating) (NAD+) activity
B	0005829	cellular_component	cytosol
B	0006090	biological_process	pyruvate metabolic process
B	0006108	biological_process	malate metabolic process
B	0008948	molecular_function	oxaloacetate decarboxylase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
C	0003824	molecular_function	catalytic activity
C	0004470	molecular_function	malic enzyme activity
C	0004471	molecular_function	malate dehydrogenase (decarboxylating) (NAD+) activity
C	0005829	cellular_component	cytosol
C	0006090	biological_process	pyruvate metabolic process
C	0006108	biological_process	malate metabolic process
C	0008948	molecular_function	oxaloacetate decarboxylase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding
D	0003824	molecular_function	catalytic activity
D	0004470	molecular_function	malic enzyme activity
D	0004471	molecular_function	malate dehydrogenase (decarboxylating) (NAD+) activity
D	0005829	cellular_component	cytosol
D	0006090	biological_process	pyruvate metabolic process
D	0006108	biological_process	malate metabolic process
D	0008948	molecular_function	oxaloacetate decarboxylase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0046872	molecular_function	metal ion binding
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue GOL A 601

Chain	Residue
A	GLY296

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site_id	AC2
Number of Residues	2
Details	binding site for residue GOL C 601

Chain	Residue
C	ARG30
C	GLY33

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Functional Information from PROSITE/UniProt

site_id	PS00331
Number of Residues	17
Details	MALIC_ENZYMES Malic enzymes signature. FnDDmqGTGaVvLAAVY

Chain	Residue	Details
A	PHE261-TYR277

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P40927

Chain	Residue	Details
A	TYR96
B	TYR96
C	TYR96
D	TYR96

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P40927

Chain	Residue	Details
A	LYS169
B	LYS169
C	LYS169
D	LYS169

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site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P40927

Chain	Residue	Details
A	ASN410
A	ASN455
B	GLU240
B	ASP241
B	ASP264
B	ALA297
B	ASN410
B	ASN455
C	GLU240
C	ASP241
C	ASP264
C	ALA297
C	ASN410
C	ASN455
D	GLU240
D	ASP241
D	ASP264
D	ALA297
D	ASN410
D	ASN455
A	GLU240
A	ASP241
A	ASP264
A	ALA297

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