6UPH

Structure of a Yeast Centromeric Nucleosome at 2.7 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000070	biological_process	mitotic sister chromatid segregation
A	0000278	biological_process	mitotic cell cycle
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0000779	cellular_component	condensed chromosome, centromeric region
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005729	cellular_component	2-micrometer circle DNA
A	0005777	cellular_component	peroxisome
A	0007080	biological_process	mitotic metaphase chromosome alignment
A	0019237	molecular_function	centromeric DNA binding
A	0030527	molecular_function	structural constituent of chromatin
A	0030543	biological_process	2-micrometer plasmid partitioning
A	0031492	molecular_function	nucleosomal DNA binding
A	0031507	biological_process	heterochromatin formation
A	0043505	cellular_component	CENP-A containing nucleosome
A	0043565	molecular_function	sequence-specific DNA binding
A	0046982	molecular_function	protein heterodimerization activity
A	0051382	biological_process	kinetochore assembly
A	0061644	biological_process	protein localization to CENP-A containing chromatin
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0030527	molecular_function	structural constituent of chromatin
B	0043505	cellular_component	CENP-A containing nucleosome
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006281	biological_process	DNA repair
C	0006974	biological_process	DNA damage response
C	0030527	molecular_function	structural constituent of chromatin
C	0043505	cellular_component	CENP-A containing nucleosome
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0030527	molecular_function	structural constituent of chromatin
D	0043505	cellular_component	CENP-A containing nucleosome
D	0046982	molecular_function	protein heterodimerization activity
E	0000070	biological_process	mitotic sister chromatid segregation
E	0000278	biological_process	mitotic cell cycle
E	0000775	cellular_component	chromosome, centromeric region
E	0000776	cellular_component	kinetochore
E	0000779	cellular_component	condensed chromosome, centromeric region
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005729	cellular_component	2-micrometer circle DNA
E	0005777	cellular_component	peroxisome
E	0007080	biological_process	mitotic metaphase chromosome alignment
E	0019237	molecular_function	centromeric DNA binding
E	0030527	molecular_function	structural constituent of chromatin
E	0030543	biological_process	2-micrometer plasmid partitioning
E	0031492	molecular_function	nucleosomal DNA binding
E	0031507	biological_process	heterochromatin formation
E	0043505	cellular_component	CENP-A containing nucleosome
E	0043565	molecular_function	sequence-specific DNA binding
E	0046982	molecular_function	protein heterodimerization activity
E	0051382	biological_process	kinetochore assembly
E	0061644	biological_process	protein localization to CENP-A containing chromatin
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0030527	molecular_function	structural constituent of chromatin
F	0043505	cellular_component	CENP-A containing nucleosome
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006281	biological_process	DNA repair
G	0006974	biological_process	DNA damage response
G	0030527	molecular_function	structural constituent of chromatin
G	0043505	cellular_component	CENP-A containing nucleosome
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0030527	molecular_function	structural constituent of chromatin
H	0043505	cellular_component	CENP-A containing nucleosome
H	0046982	molecular_function	protein heterodimerization activity

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. SQEL

Chain	Residue	Details
C	SER127-LEU130

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site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLtFPV

Chain	Residue	Details
C	ALA22-VAL28

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site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY15-HIS19

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlILpGELaKHAVSEG

Chain	Residue	Details
D	ARG97-GLY119

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFaRLVKEV

Chain	Residue	Details
A	PRO157-VAL165

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"UniProtKB","id":"P04911","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P02293","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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