6UP5
Triosephosphate isomerase deficiency: Effect of F240L mutation on enzyme structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004807 | molecular_function | triose-phosphate isomerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008929 | molecular_function | methylglyoxal synthase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019242 | biological_process | methylglyoxal biosynthetic process |
| A | 0019563 | biological_process | glycerol catabolic process |
| A | 0019682 | biological_process | glyceraldehyde-3-phosphate metabolic process |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| A | 0061621 | biological_process | canonical glycolysis |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0004807 | molecular_function | triose-phosphate isomerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0008929 | molecular_function | methylglyoxal synthase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019242 | biological_process | methylglyoxal biosynthetic process |
| B | 0019563 | biological_process | glycerol catabolic process |
| B | 0019682 | biological_process | glyceraldehyde-3-phosphate metabolic process |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| B | 0061621 | biological_process | canonical glycolysis |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | ARG52 |
| A | LEU55 |
| A | PRO57 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | SER96 |
| A | VAL101 |
| A | ILE170 |
| A | HOH415 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue IPA A 303 |
| Chain | Residue |
| B | ARG17 |
| B | SER20 |
| B | HOH526 |
| A | ASN71 |
| B | GLY16 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue IPA A 304 |
| Chain | Residue |
| A | GLY16 |
| A | SER20 |
| A | HOH582 |
| B | ASN71 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue PGA B 301 |
| Chain | Residue |
| B | LYS13 |
| B | HIS95 |
| B | GLU165 |
| B | ALA169 |
| B | ILE170 |
| B | GLY171 |
| B | GLY210 |
| B | SER211 |
| B | GLY232 |
| B | GLY233 |
| B | HOH416 |
| B | HOH422 |
| B | HOH475 |
| B | HOH493 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| A | PHE102 |
| B | PHE102 |
| B | GLY103 |
| B | HOH529 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue IPA B 303 |
| Chain | Residue |
| B | ARG52 |
| B | GLN53 |
| B | LEU55 |
| B | HOH546 |
Functional Information from PROSITE/UniProt
| site_id | PS00171 |
| Number of Residues | 11 |
| Details | TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG |
| Chain | Residue | Details |
| A | ALA163-GLY173 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Electrophile => ECO:0000255|PROSITE-ProRule:PRU10127, ECO:0000269|PubMed:8061610 |
| Chain | Residue | Details |
| B | LYS58 | |
| A | LYS58 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10127, ECO:0000269|PubMed:8061610 |
| Chain | Residue | Details |
| B | GLY128 | |
| A | GLY128 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P17751 |
| Chain | Residue | Details |
| B | ALA30 | |
| B | GLY171 | |
| A | ALA30 | |
| A | GLY171 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | ALA42 | |
| B | ALA42 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P48500 |
| Chain | Residue | Details |
| B | LYS68 | |
| B | VAL160 | |
| A | VAL160 | |
| A | LYS68 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P17751 |
| Chain | Residue | Details |
| B | GLN111 | |
| A | GLN111 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P17751 |
| Chain | Residue | Details |
| B | ASP156 | |
| B | ALA118 | |
| A | ALA118 | |
| A | ASP156 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P17751 |
| Chain | Residue | Details |
| B | LEU121 | |
| A | LEU121 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P17751 |
| Chain | Residue | Details |
| B | GLU135 | |
| A | GLU135 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | LYS174 | |
| B | LYS174 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | ALA176 | |
| B | ALA176 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | HIS185 | |
| B | HIS185 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | VAL200 | |
| B | VAL200 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| A | GLU104 | |
| B | GLU104 |
