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6UO5

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) Y363F mutant complexed with AR-42

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0004407molecular_functionhistone deacetylase activity
A0006325biological_processchromatin organization
A0016575biological_processhistone deacetylation
Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue QCP A 501
ChainResidue
AHIS82
AASP323
ALYS330
AGLY361
APHE363
AZN503
AHOH613
AHOH741
AHOH759
AGLU94
ATHR98
ASER150
AGLY201
APHE202
AASP230
AHIS232
ATRP261

site_idAC2
Number of Residues5
Detailsbinding site for residue EDO A 502
ChainResidue
AHIS345
ALYS348
ASER378
AGLY381
AASP382

site_idAC3
Number of Residues5
Detailsbinding site for residue ZN A 503
ChainResidue
AASP230
AHIS232
AASP323
AQCP501
AHOH613

site_idAC4
Number of Residues5
Detailsbinding site for residue K A 504
ChainResidue
AASP228
AASP230
AHIS232
ASER251
AVAL252

site_idAC5
Number of Residues5
Detailsbinding site for residue K A 505
ChainResidue
APHE241
AASP244
AVAL247
ATYR280
AHOH658

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PDB entries from 2024-11-13

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