6UKZ

STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000794	cellular_component	condensed nuclear chromosome
A	0002218	biological_process	activation of innate immune response
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005940	cellular_component	septin ring
A	0016925	biological_process	protein sumoylation
A	0031386	molecular_function	protein tag activity
A	0032481	biological_process	positive regulation of type I interferon production
A	0042802	molecular_function	identical protein binding
A	0044389	molecular_function	ubiquitin-like protein ligase binding
B	0000794	cellular_component	condensed nuclear chromosome
B	0002218	biological_process	activation of innate immune response
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005940	cellular_component	septin ring
B	0016925	biological_process	protein sumoylation
B	0031386	molecular_function	protein tag activity
B	0032481	biological_process	positive regulation of type I interferon production
B	0042802	molecular_function	identical protein binding
B	0044389	molecular_function	ubiquitin-like protein ligase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue QBG A 401

Chain	Residue
A	SER162
A	HOH506
A	HOH518
A	HOH540
A	HOH578
A	HOH582
B	SER162
B	TYR163
B	GLY166
B	TYR167
B	ARG238
A	TYR163
B	THR263
B	PRO264
A	GLY166
A	TYR167
A	ILE235
A	ARG238
A	THR263
A	PRO264
A	HOH505

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950

Chain	Residue	Details
A	SER51
B	SER51

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358

Chain	Residue	Details
A	SER53
B	SER53

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
A	GLY147
B	GLY147

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q3TBT3

Chain	Residue	Details
A	LYS338
B	LYS338

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site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4F5Y

Chain	Residue	Details
A	SER162
B	SER162

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site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728659, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5D, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G

Chain	Residue	Details
A	TYR167
B	TYR167

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:37379839, ECO:0007744|PDB:8GJX

Chain	Residue	Details
A	ARG238
B	ARG238

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site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G

Chain	Residue	Details
A	THR263
B	THR263

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:37832545

Chain	Residue	Details
A	THR229
B	THR229

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site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:37832545

Chain	Residue	Details
A	SER241
B	SER241

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site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013

Chain	Residue	Details
A	LYS236
B	LYS236

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