6UKA
Crystal structure of RHOG and ELMO complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0007015 | biological_process | actin filament organization |
| A | 0007163 | biological_process | establishment or maintenance of cell polarity |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0007266 | biological_process | Rho protein signal transduction |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0016601 | biological_process | Rac protein signal transduction |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0030667 | cellular_component | secretory granule membrane |
| A | 0030865 | biological_process | cortical cytoskeleton organization |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| A | 0042995 | cellular_component | cell projection |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0090630 | biological_process | activation of GTPase activity |
| A | 0098794 | cellular_component | postsynapse |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0150052 | biological_process | regulation of postsynapse assembly |
| A | 1903078 | biological_process | positive regulation of protein localization to plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue GNP A 201 |
| Chain | Residue |
| A | GLY12 |
| A | PRO34 |
| A | THR35 |
| A | GLY60 |
| A | LYS116 |
| A | ASP118 |
| A | LEU119 |
| A | SER158 |
| A | ALA159 |
| A | LEU160 |
| A | MG202 |
| A | ALA13 |
| A | HOH314 |
| A | HOH317 |
| A | HOH321 |
| A | HOH329 |
| A | HOH349 |
| A | HOH352 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | THR17 |
| A | CYS18 |
| A | PHE28 |
| A | TYR32 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | THR17 |
| A | THR35 |
| A | GNP201 |
| A | HOH314 |
| A | HOH317 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P61586","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylasparagine; by botulinum toxin","evidences":[{"source":"UniProtKB","id":"P61586","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxin TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17947660","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18034455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
