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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6UJB

Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001568biological_processblood vessel development
A0001570biological_processvasculogenesis
A0001618molecular_functionvirus receptor activity
A0001704biological_processformation of primary germ layer
A0001846molecular_functionopsonin binding
A0001968molecular_functionfibronectin binding
A0002020molecular_functionprotease binding
A0005080molecular_functionprotein kinase C binding
A0005102molecular_functionsignaling receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007229biological_processintegrin-mediated signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0008305cellular_componentintegrin complex
A0009888biological_processtissue development
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010745biological_processnegative regulation of macrophage derived foam cell differentiation
A0010888biological_processnegative regulation of lipid storage
A0010989biological_processnegative regulation of low-density lipoprotein particle clearance
A0015026molecular_functioncoreceptor activity
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0017134molecular_functionfibroblast growth factor binding
A0019960molecular_functionC-X3-C chemokine binding
A0030335biological_processpositive regulation of cell migration
A0031258cellular_componentlamellipodium membrane
A0031527cellular_componentfilopodium membrane
A0031528cellular_componentmicrovillus membrane
A0031589biological_processcell-substrate adhesion
A0031994molecular_functioninsulin-like growth factor I binding
A0032369biological_processnegative regulation of lipid transport
A0032587cellular_componentruffle membrane
A0033627biological_processcell adhesion mediated by integrin
A0033690biological_processpositive regulation of osteoblast proliferation
A0034113biological_processheterotypic cell-cell adhesion
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0034682cellular_componentintegrin alphav-beta1 complex
A0034683cellular_componentintegrin alphav-beta3 complex
A0034684cellular_componentintegrin alphav-beta5 complex
A0034685cellular_componentintegrin alphav-beta6 complex
A0034686cellular_componentintegrin alphav-beta8 complex
A0035313biological_processwound healing, spreading of epidermal cells
A0035579cellular_componentspecific granule membrane
A0035866cellular_componentalphav-beta3 integrin-PKCalpha complex
A0035867cellular_componentalphav-beta3 integrin-IGF-1-IGF1R complex
A0035868cellular_componentalphav-beta3 integrin-HMGB1 complex
A0035987biological_processendodermal cell differentiation
A0038023molecular_functionsignaling receptor activity
A0038027biological_processapolipoprotein A-I-mediated signaling pathway
A0038132molecular_functionneuregulin binding
A0043277biological_processapoptotic cell clearance
A0045335cellular_componentphagocytic vesicle
A0045785biological_processpositive regulation of cell adhesion
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0050431molecular_functiontransforming growth factor beta binding
A0050748biological_processnegative regulation of lipoprotein metabolic process
A0050764biological_processregulation of phagocytosis
A0050840molecular_functionextracellular matrix binding
A0050919biological_processnegative chemotaxis
A0051057biological_processpositive regulation of small GTPase mediated signal transduction
A0070062cellular_componentextracellular exosome
A0070371biological_processERK1 and ERK2 cascade
A0070588biological_processcalcium ion transmembrane transport
A0071604biological_processtransforming growth factor beta production
A0085017biological_processentry into host cell by a symbiont-containing vacuole
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0098609biological_processcell-cell adhesion
A1901388biological_processobsolete regulation of transforming growth factor beta activation
A1902533biological_processpositive regulation of intracellular signal transduction
A1990430molecular_functionextracellular matrix protein binding
A2000536biological_processnegative regulation of entry of bacterium into host cell
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0001570biological_processvasculogenesis
B0001573biological_processganglioside metabolic process
B0005178molecular_functionintegrin binding
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006955biological_processimmune response
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0007166biological_processcell surface receptor signaling pathway
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007229biological_processintegrin-mediated signaling pathway
B0008305cellular_componentintegrin complex
B0009615biological_processresponse to virus
B0009986cellular_componentcell surface
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0016477biological_processcell migration
B0030154biological_processcell differentiation
B0033627biological_processcell adhesion mediated by integrin
B0034686cellular_componentintegrin alphav-beta8 complex
B0043379biological_processmemory T cell differentiation
B0045766biological_processpositive regulation of angiogenesis
B0046872molecular_functionmetal ion binding
B0051216biological_processcartilage development
B0060022biological_processhard palate development
B0060674biological_processplacenta blood vessel development
B0061520biological_processLangerhans cell differentiation
B0070062cellular_componentextracellular exosome
B0098609biological_processcell-cell adhesion
B1901388biological_processobsolete regulation of transforming growth factor beta activation
B1990430molecular_functionextracellular matrix protein binding
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CqCfsGweGDrC
ChainResidueDetails
BCYS530-CYS541
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. VnSKGQVCSGRG
ChainResidueDetails
BVAL552-GLY563
site_idPS00242
Number of Residues8
DetailsINTEGRIN_ALPHA Integrins alpha chain signature. YRmGFFkR
ChainResidueDetails
ATYR986-ARG993
site_idPS00243
Number of Residues14
DetailsI_EGF_1 Integrins beta chain EGF (I-EGF) domain signature. CsGr..GvCvCgkCsC
ChainResidueDetails
BCYS478-CYS491
BCYS559-CYS572
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
FTYR197-HIS203
site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CqCfsGWegdrcq..C
ChainResidueDetails
BCYS530-CYS543
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues66
DetailsRepeat: {"description":"FG-GAP 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues61
DetailsRepeat: {"description":"FG-GAP 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues52
DetailsRepeat: {"description":"FG-GAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues54
DetailsRepeat: {"description":"FG-GAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues65
DetailsRepeat: {"description":"FG-GAP 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues57
DetailsRepeat: {"description":"FG-GAP 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues63
DetailsRepeat: {"description":"FG-GAP 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FFG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues238
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OM2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OM2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsBinding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OM2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OM1","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OM2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-10-29

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