6UIQ

Crystal structure of wild-type human phosphoglucomutase 1 in complex with Glucose-6-Phosphate

Replaces:  6BJ0

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004614	molecular_function	phosphoglucomutase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0016868	molecular_function	intramolecular phosphotransferase activity
A	0033499	biological_process	galactose catabolic process via UDP-galactose
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071704	biological_process	obsolete organic substance metabolic process
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000287	molecular_function	magnesium ion binding
B	0004614	molecular_function	phosphoglucomutase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006006	biological_process	glucose metabolic process
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0016868	molecular_function	intramolecular phosphotransferase activity
B	0033499	biological_process	galactose catabolic process via UDP-galactose
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0071704	biological_process	obsolete organic substance metabolic process
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00710
Number of Residues	10
Details	PGM_PMM Phosphoglucomutase and phosphomannomutase phosphoserine signature. GIiLTASHNP

Chain	Residue	Details
B	GLY111-PRO120

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Phosphoserine intermediate => ECO:0000269|PubMed:25288802

Chain	Residue	Details
B	SER117
A	SER117

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00949

Chain	Residue	Details
B	ARG23
A	GLU376
A	SER378
A	LYS389
B	ARG293
B	THR357
B	GLU376
B	SER378
B	LYS389
A	ARG23
A	ARG293
A	THR357

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: via phosphate groupe => ECO:0000269|PubMed:25288802

Chain	Residue	Details
B	SER117
A	SER117

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:26972339, ECO:0007744|PDB:5EPC, ECO:0007744|PDB:5F9C

Chain	Residue	Details
B	ASP288
B	ASP290
B	ASP292
A	ASP288
A	ASP290
A	ASP292

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	MET1
A	MET1

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS16
A	LYS16

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9D0F9

Chain	Residue	Details
B	THR115
B	THR507
A	THR115
A	THR507

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:25288802, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
B	SER117
A	SER117

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P38652

Chain	Residue	Details
B	SER134
A	SER477
A	SER485
A	SER541
B	SER213
B	SER369
B	SER477
B	SER485
B	SER541
A	SER134
A	SER213
A	SER369

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	THR185
A	THR185

---

site_id	SWS_FT_FI11
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER201
A	SER509
B	SER206
B	SER378
B	SER505
B	SER509
A	SER201
A	SER206
A	SER378
A	SER505

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9D0F9

Chain	Residue	Details
B	LYS349
A	LYS349

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9D0F9

Chain	Residue	Details
B	TYR353
A	TYR353

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9D0F9

Chain	Residue	Details
B	LYS419
A	LYS419

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PAK1 => ECO:0000269|PubMed:15378030

Chain	Residue	Details
B	THR467
A	THR467

---