6UGT

Crystal structure of the Fab fragment of PF06438179/GP1111 an infliximab biosimilar in a I-centered orthorhombic crystal form, Lot A

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006955	biological_process	immune response
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0006955	biological_process	immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue EDO H 301

Chain	Residue
H	ASN31
H	SER55
H	TYR102
H	TYR103
H	TYR103
H	GLY104
H	SER105
H	HOH413
L	TYR50

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO H 302

Chain	Residue
H	ALA165
H	LEU166
H	THR167
H	SER168

---

site_id	AC3
Number of Residues	8
Details	binding site for residue EDO H 303

Chain	Residue
H	VAL176
H	SER184
H	LEU185
H	SER186
H	HOH434
L	THR178
L	HOH430
L	HOH453

---

site_id	AC4
Number of Residues	8
Details	binding site for residue EDO L 301

Chain	Residue
H	SER193
H	HOH433
L	ALA112
L	SER114
L	ASN137
L	ASN138
L	HOH401
L	HOH402

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO A 301

Chain	Residue
A	ASN31
A	TYR102
A	TYR103
A	TYR103
A	GLY104
A	HOH402
B	TYR50

---

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO A 302

Chain	Residue
A	LEU148
A	SER184
A	LEU185
A	SER186
B	THR178
B	HOH429
B	HOH440

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO B 301

Chain	Residue
A	TYR97
B	GLN38
B	ARG39
B	THR40
B	ASN41
B	GLY42
B	HOH479

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR201-HIS207
L	TYR192-HIS198

---